Pregnenolone  孕烯醇酮

主要建議用途

   • 沒有任何

其他建議用途

   • 整體老化； 阿茲海默氏症; 沮喪; 增強記憶力和心理功能； 疲勞; 更年期症狀； 骨質疏鬆症； 帕金森氏症； 類風濕關節炎; 壓力; 減肥

孕烯醇酮被稱為「所有類固醇激素的祖母」。 身體用膽固醇製造它，然後用它製造睪固酮、可的松、黃體酮、雌激素、DHEA、雄烯二酮、醛固酮和「類固醇」家族中的所有其他荷爾蒙。

使用孕烯醇酮的原因之一是許多這些荷爾蒙的水平隨著年齡的增長而下降。 支持者說，透過服用孕烯醇酮補充劑，您可以將所有荷爾蒙保持在年輕水平。 然而，孕烯醇酮水平本身不會隨著年齡的增長而下降，並且沒有跡象表明服用額外的孕烯醇酮會增加任何其他激素的水平。 此外，即使確實如此，也不代表使用孕烯醇酮是個好主意。

類固醇激素是一種強大的物質，它們既可能帶來傷害，也可能帶來好處。 長期使用可的松會導致嚴重骨質疏鬆； 雌激素會增加罹癌的風險； 合成代謝類固醇（運動員使用）可能會導致肝臟問題並對心臟造成壓力。 我們真的不知道使用孕烯醇酮可能會帶來什麼長期後果。

事實上，諷刺的是，孕烯醇酮在法律上被歸類為「膳食補充劑」。 孕烯醇酮不是營養素。 它是一種藥物，就像雌激素、可的松和醛固酮是藥物一樣。 我們建議在我們更多地了解它的真正用途之前不要使用它。

目前，透過雙盲、安慰劑對照研究記錄到的孕烯醇酮只有一種作用：由於完全不清楚的原因，經常使用孕烯醇酮可能會大大降低安定家族藥物的鎮靜作用。

來源

孕烯醇酮通常不會從食物中獲取。 您的身體會用膽固醇製造它。 補充孕烯醇酮是在實驗室中用大豆中發現的物質合成製成的。

治療劑量

孕烯醇酮的非典型建議劑量是每天 30 毫克，但有些研究使用的劑量高達 700 毫克。

治療用途

如果您瀏覽網路或閱讀健康雜誌，您會發現孕烯醇酮被描述為可以治療大量健康問題的藥物，包括：阿茲海默症、更年期症狀、帕金森氏症、骨質疏鬆症、疲勞、壓力、憂鬱和類風濕關節炎。 它還可以幫助您減肥，提高腦力，讓您再次感覺年輕。 然而，就像許多過度宣傳的新補充劑一樣，這些用途幾乎沒有任何科學證據。 大鼠的研究顯示孕烯醇酮可以增強記憶力2,3，但尚未進行人體研究。

安全問題

孕烯醇酮是一種強大的激素，而不是我們從食物中自然獲得的營養素。 您應該像對待藥物一樣謹慎對待這種補充劑。 無論出於何種目的，它都是一種藥物。 服用前最好先諮詢您的醫生。 孕烯醇酮絕對不建議用於兒童、孕婦或哺乳期婦女，或患有肝臟或腎臟疾病的人。

如上所述，孕烯醇酮可能會降低安定家族（苯二氮平類藥物）鎮靜劑的有效性。 這意味著，如果您使用苯二氮平類藥物來緩解睡眠或焦慮，它們可能效果不佳。

Principal Proposed Uses
  • None
Other Proposed Uses
  • Aging in General; Alzheimers Disease; Depression; Enhancing Memory and Mental Function; Fatigue; Menopausal Symptoms; Osteoporosis; Parkinsons Disease; Rheumatoid Arthritis; Stress; Weight Loss

Pregnenolone has been called "the grandmother of all steroid hormones." The body manufactures it from cholesterol, and then uses it to make testosterone, cortisone, progesterone, estrogen, DHEA, androstenedione, aldosterone, and all other hormones in the "steroid" family.

One reason given for using pregnenolone is that the level of many of these hormones declines with age. By taking pregnenolone supplements, proponents say, you can keep all your hormones at youthful levels. However, pregnenolone levels themselves dont decline with age,¹  and there is no indication that taking extra pregnenolone will increase the levels of any other hormones. Furthermore, even if it did, that doesnt mean using pregnenolone is a great idea.

Steroid hormones are powerful substances, and they can cause harm as well as benefit. Long-term use of cortisone causes severe osteoporosis; estrogen can increase the risk of cancer; and anabolic steroids (used by athletes) may cause liver problems and stress the heart. We really have very little idea what long-term consequences the use of pregnenolone might entail.

Actually, it is ironic that pregnenolone is legally classified as a "dietary supplement" at all. Pregnenolone is not a nutrient. It is a drug, just as estrogen, cortisone, and aldosterone are drugs. We recommend not using it until we know more about what it really does.

At present, there is only one effect of pregnenolone that has been documented via double-blind, placebo-controlled studies: for reasons that are not at all clear, regular use of pregnenolone may greatly decrease the sedative effect of drugs in the Valium family.⁴ 

Sources

Pregnenolone is not normally obtained from foods. Your body manufactures it from cholesterol. Supplemental pregnenolone is made synthetically in a lab from substances found in soybeans.

Therapeutic Dosages

Atypical recommended dosage of pregnenolone is 30 mg daily, but some studies have used as much as 700 mg.

Therapeutic Uses

If you browse the Internet or read health magazines, youll find pregnenolone described as a treatment for an enormous list of health problems, including: Alzheimers disease, menopausal symptoms, Parkinsons disease, osteoporosis, fatigue, stress, depression, and rheumatoid arthritis. It is also supposed to help you lose weight, improve your brain power, and make you feel young again. However, like so many overhyped new supplements, there is little to no scientific evidence for any of these uses. Studies involving rats suggest that pregnenolone may enhance memory,^2,3  but there have been no human studies.

Safety Issues

Pregnenolone is a powerful hormone, not a nutrient we would naturally get in our food. You should approach this supplement with caution, as if it were a drug. For all intents and purposes, it isa drug. It would be best to consult your doctor before taking it. Pregnenolone is definitely not recommended for children, pregnant or nursing women, or those with liver or kidney disease.

As noted above, pregnenolone may decrease the effectiveness of sedatives in the Valium family (benzodiazepines). This means that if you are using benzodiazepine drugs for sleep or for anxiety, they may not work as well.

Interactions You Should Know About

If you are using:

Drugs in the benzodiazepinefamily: Pregnenolone may decrease their effectiveness.

References[ - ]

1. Meldrum DR, Davidson BJ, Tataryn IV, et al. Changes in circulating steroids with aging in postmenopausal women. Obstet Gynecol. 1981;57:624-628.

2. Flood JF, Morley JE, Roberts E. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proc Natl Acad Sci USA. 1995;92:10806-10810.

3. Flood JF, Morley JE, Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci U S A. 1992;89:1567-1571.

4. Meieran SE, Reus VI, Webster R, et al. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology. 2004;29:486-500.