 
字體：小 中 大 |
|
|
|||||||||||||||
| 2009/02/06 10:57:07瀏覽2435｜回應0｜推薦20 | |||||||||||||||
Coromega乳膠狀魚油比一般膠囊狀魚油多三倍吸收力 明尼蘇達大學一般臨床的研究中心和藥部門，梅奧門診部發表 在藥理學中，『生物利用度』通常用來衡量一種藥品對循環系統的影響程度。若某種樣品若是通過靜脈，則其生物利用度為100%、若通過嘴巴進入體內，則生物利用度將會減弱（因不完全吸收及新陳代謝關係）。因利用度影響到劑量及服用方式，所以生物利用度可說是藥理學中評估藥理效能中最重要的指標。 研究摘要 Omega-3脂肪酸、EPA 以及DHA ,在營養和疾病管理過程中具有非常重要的特性。現在的魚油都以膠囊狀呈現，但是現在已經有了新的方式。新的調味過乳膠狀魚油調劑品，提供更精簡跟接近魚油的產品。油在水乳膠狀中被假定更容易吸收與消化脂肪酸，使其功效更能發揮‧一個隨機化排列，交叉設計研究，讓10個實驗者攝取5g Coromega（含4g 魚油），或者是4g 的膠囊狀魚油，經消化與吸收後，比較其血液中在2、4、8、24、48小時後EPA 和DHA的含量。吸收的高峰預估於8小時後至24小時間‧從AUC曲線中看出，8小時後乳膠狀魚油大幅提升omega-3脂肪酸的功效‧受訪者表示，服用乳膠狀配方完全沒有用使用後問題，不像膠囊狀還有”魚腥味飽咯”的問題‧ 本研究顯示水乳膠狀魚油，是最有功效最被接受，提供長鏈 omega-3脂肪酸的方式‧ (圖片及數據請參見Coromega網站) http://www.coromega.com/01What/f_bioavailability/f_body.html http://class.ruten.com.tw/user/index00.php?c=&m=&o=3&p=&s=weihan97
BACKGROUND 背景
The omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have properties important in nutrition and disease management.
Presently fish oil supplementation relies on capsular triglyceride but novel delivery systems are emerging.
Flavored emulsified lipid preparations provide a simplified approach to fish oil delivery.
Oil in water emulsions are hypothesized to possess advantages in the digestion and absorption of their fatty acids thus increasing the "bioavailability" of the active components.
HYPOTHESIS AND SPECIFIC AIMS
Hypothesis: Emulsified triglyceride will be absorbed faster and to a greater extent compared to a similar dose of the parent triglyceride based on its pre-emulsified state.
Specific Aims: § § To evaluate the effects of feeding a single dose, 4g fish oil ( 5g Coromega®), of emulsified lipid containing EPA and DHA from fish oil on plasma fatty acids over a 48 hour period. § § To evaluate the extent and rate of absorption of EPA and DHA in healthy subjects fed equivalent doses of fish oil from either a emulsified triglyceride versus a encapsulated triglyceride of similar EPA and DHA dosages.
STUDY DESIGN
A randomized and crossover design with 10 subjects § § Healthy adults ages 18 to 60 § § Body mass index between 22 and 32 kg /m2 § § Medical history demonstrating good health § § Nonsmokers § § Consumption of a typical American diet with no unusual dietary habits § § Willingness to comply with the study protocol
Treatments § § Active: 5 g ( 4 g of fish oil) of Coromega® § § Placebo: 4 g of parent oil
Assessment of absorption kinetics of EPA and DHA § § Plasma obtained at baseline, 2, 4, 8, 24 and 48 hours § § Peak absorption at 8 hours was assessed in total phospholipid
RESULTS
Total Omega-3 Percent Increase from Baseline
SUMMARY AND CONCLUSIONS
Summary Emulsified FO promoted increased bioavailability of omega-3 fatty acids with enhanced area under the curve (AUC) through 8 hours.
The AUC (% FFA x min) was statistically significant for Total omega-3 fatty acids (emulsified FO vs. parent FO, respectively) 1102 ± 23, 319 ± 13 (p = 0.012), EPA 771 ± 161, 314 ± 82 (p = 0.001). DHA trended toward significance for 393 ± 29, 70 ± 16 (p = 0.18).
Subjects reported no tolerance problems with the emulsified lipid preparation compared to mild reports of “fishy burp” with the capsular triglyceride.
Conclusions Oil in water emulsions are a highly bioavailable, highly tolerable method of delivery for long chain omega-3 fatty acids from fish oil |
|||||||||||||||
| ( 知識學習｜語言 ) |
