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2008/05/19 20:19:26瀏覽579|回應0|推薦2

In order to product recovery with solvents of methanol and ethanol, the methanol showed higher percentage of extraction of CPT and 9-Me-CPT.

為能夠使用甲醇和乙醇溶劑促成生成物的還原,甲醇顯示有較高百分比的喜樹鹼和9-甲氧基喜樹鹼萃取物。

 

The extraction temperature was found to be one of the important factors.

萃取溫度經發現係為重要因素之ㄧ。

 

The percentage extraction of alkaloids was minimum by ultrasonic extraction techniques.

生物鹼的百分比使用超音波萃取技術進行最低百分比的萃取處理。

 

The MAE reduce the extraction time and required 3 min to extract similar percentage of extraction of alkaloids whereas Soxhlet extraction techniques need 2 h which is 40 times more.

微波粹取法可降低萃取時間,需3分鐘萃取類似百分比的生物鹼,但索氏粹取法則需2小時,多出40分鐘。

 

Keywords: Nothapodytes  foetida(青翠枝)  Camptothecin(喜樹鹼)  9-Methoxycamptothecin(9-甲氧基喜樹鹼)  anti-cancer drug(抗癌藥物)

 

When compared with stirring extraction, ultrasonic extraction and Soxhlet extraction, and the MAE system showed extraction efficiency in short time.

比較攪拌萃取物時,超音波萃取和索氏萃取法,以及MAE系統在短期即有萃取效應。

 

Therefore, MAE is an alternative extraction technique for speedy extraction of anti-cancer drug CPT and 9-Me-CPT from plant material of N. foetida.

所以,MAE 即為N. foetida.成份抗癌藥劑CPT 9-Me-章的快速萃取方法。

 

The results indicated MAE for large-scale efficient extraction of camptothecin from plant materials.

結果顯示MAE具有大量的植物喜樹鹼高效率萃取功能。

 

Nothapodytes foetida (Slemure) Wight [formerly, Mappia foetida(Miers)] is abundant in the Western Ghats of India and a rich source of camptothecin and 9-methoxycamptothecin (Fig. 1) [1] and [2].

Nothapodytes foetida (Slemure) Wight [過去即為Mappia foetida (Miers)]常見於印度西方,是豐富的喜樹鹼(camptothecin) 9-methoxycamptothecin (Fig. 1) [1] and [2] 來源。

 

Biological screenings have recognized that camptothecin and 9-methoxycamptothecin have promising anti-cancer activity [3].       

生物篩檢則認為camptothecin 9-methoxycamptothecin 具有良好的抗癌特性[3]

 

Camptothecin itself is not used clinically due to its cytotoxicity, but its derivatives are most effective for the treatment of cancer.

喜樹鹼(Camptothecin)本身因為其細胞毒性而不作為化學物使用,但該特性成為癌症的有效治療藥劑。.

 

We have evaluated the contents of camptothecin and 9-methoxycamptothecin in various parts and seed-parts of N. foetida.

 

我們已在N. foetida的不同部位和種子中,測定其camptothecin and 9-methoxycamptothecin 含量。

 

In regard to various plant-parts, maximum concentrations of alkaloids were obtained in bark (0.27% of camptothecin and 0.11% of 9-methoxycamptothecin) followed by root, stem, and leaves.

關於不同的植物部位,生物鹼的最高濃度即來自樹皮0.27%camptothecin 0.11% 9-methoxycamptothecin),然後則是根部、莖部和葉子的含量。

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