英國脱歐可能會驅使因不確定性而感到不安的全球投資者，從拉美等風險高的地區撤資，轉向美國等地；英國脱歐會對歐洲與非洲、加勒比和太平洋國家集團（African, Caribbean and Pacific Group of States）的關係產生影響，英國作為歐盟成員國曾簽署的加勒比論壇經濟合作協議（CARIFORUM Economic Partnership Agreement）以及一些中南美洲的聯合協議，都可能會因英國脱歐而受到影響。
United Kingdom exit may be driven by uncertainty and nervous investors around the globe, divest from Latin America and other areas of high risk, turn to United States and other places; United Kingdom exit on Europe and the African, Caribbean and Pacific Group of States (African, Caribbean and Pacific Group of States) affect the relationship, United Kingdom as CARIFORUM economic partnership agreement signed by Member States of the European Union (CARIFORUM Economic Partnership Agreement) and a number of joint agreements in Central and South America, may United Kingdom affected by the exit.