Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Latex pillow OEM production in Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Smart pillow ODM manufacturer Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.High-performance insole OEM Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow factory in Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China high-end foam product OEM/ODM

University of Ottawa-led team found a new viral entry for SARS-CoV-2 and suggests it may be able to use proteins to infect a wider range of cells. One of the many pressing research undertakings by the scientific community amid the ongoing COVID-19 pandemic has focused on ways the coronavirus manages to enter host cells. Now, in a study adding to the pool of knowledge about viral entry, Dr. Marceline Côté’s Faculty of Medicine lab and collaborators have published a highly compelling study showing a previously unrecognized entryway for SARS-CoV-2, the virus that causes COVID-19 and the driver of the global health crisis that’s transformed the world. Dr. Marceline Côté’s team from the University of Ottawa has found a new viral entry for SARS-CoV-2 and suggests it may be able to use proteins to infect a wider range of cells. Credit: University of Ottawa Previous studies have shown that SARS-CoV-2 as well as an earlier coronavirus, SARS-CoV-1, the virus behind the SARS outbreak in 2003, enter cells via two distinct pathways. The new research led by Dr. Côté’s lab shows a third entry route. Metalloproteinases: A Key to Viral Entry This viral entryway involves metalloproteinases, enzymes in the body with a catalytic mechanism that requires a metal, such as zinc atoms, to function. Over a series of experiments starting in 2020, Dr. Côté’s research team discovered that SARS-COV-2 can enter cells in a metalloproteinase-dependent manner. The team describes a role for two matrix metalloproteinases—MMP-2 and MMP-9—in the activation of the spike glycoprotein. What are the ramifications of this kind of viral entry?  The study published in a recent issue of iScience, an open access journal from Cell Press, suggests that variants that gravitate toward metalloproteinases may cause more havoc. Variants and Their Preferences for Entry Pathways The team’s experiments showed that some variants clearly prefer the metalloproteinases for activation. For instance, the Delta variant, a more pathogenic variant that surged in 2021, commonly used metalloproteinases for entry. Its less pathogenic successor, Omicron, did not. “SARS-CoV-2 may be able to use proteins, which are typically secreted by some activated immune cells, to cause more damage and potentially infect a wider range of cells and tissues,” says Dr. Côté, a Faculty associate professor who is the holder of the Canada Research Chair in Molecular Virology and Antiviral Therapeutics. The entry mechanism could also play a role in disease progression. Dr. Côté says the findings could have implications in the progression to severe illness and some post-COVID-19 conditions, such as the complex array of post-infection symptoms known as “long Covid.” Reference: “Identification and differential usage of a host metalloproteinase entry pathway by SARS-CoV-2 Delta and Omicron” by Mehdi Benlarbi, Geneviève Laroche, Corby Fink, Kathy Fu, Rory P. Mulloy, Alexandra Phan, Ardeshir Ariana, Corina M. Stewart, Jérémie Prévost, Guillaume Beaudoin-Bussières, Redaet Daniel, Yuxia Bo, Omar El Ferri, Julien Yockell-Lelièvre, William L. Stanford, Patrick M. Giguère, Samira Mubareka, Andrés Finzi, Gregory A. Dekaban, Jimmy D. Dikeakos and Marceline Côté, 10 October 2022, iScience. DOI: 10.1016/j.isci.2022.105316 The study’s co-first authors are Mehdi Benlarbi, an undergraduate honours’ thesis student in Dr. Cote’s lab and recipient of a uOttawa Centre for Infection, Immunity and Inflammation scholarship, and Dr. Geneviève Laroche of uOttawa. Collaborators include researchers at the University of Western Ontario, Centre de recherche du CHUM, and Sunnybrook Research Institute. Funding was provided by the Canadian Institutes of Health Research (CIHR).

Unlike birds, the evolution of bats’ wings and legs is tightly coupled, which may have prevented them from filling as many ecological niches as birds. Credit: Jason Koski/Cornell University Bats and birds showcase a fascinating contrast in their evolutionary paths, with recent research revealing bats’ wings and legs evolve in unison, limiting their ecological roles compared to birds, whose limbs evolve independently. This discovery offers new insights into why birds occupy a wider range of ecological niches and poses questions about the broader implications for other flying species like the diverse pterosaurs. Unique Traits of Bats and Birds Bats are remarkably diverse creatures, capable of climbing onto animals to drink their blood, snatching insects from leaves, or hovering to sip nectar from tropical flowers. Each of these behaviors relies on uniquely adapted wing designs. But have you ever wondered why there are no flightless bats, like ostriches that wade along riverbanks for fish, or bats that roam the open seas, akin to the wandering albatross? Scientists may now have the answer: Unlike birds, bats have evolved with a strong connection between the development of their wings and legs. This evolutionary coupling likely limits their ability to adapt to a wide variety of ecological roles, as birds have. “We initially expected to confirm that bat evolution is similar to that of birds, and that their wings and legs evolve independently of one another. The fact we found the opposite was greatly surprising,” said Andrew Orkney, postdoctoral researcher in the laboratory of Brandon Hedrick, assistant professor in the Department of Biomedical Sciences, in the College of Veterinary Medicine. Both researchers are co-corresponding authors of research published recently in Nature Ecology and Evolution. Analyzing Bone Structures Because legs and wings perform different functions, researchers had previously thought that the origin of flight in vertebrates required forelimbs and hindlimbs to evolve independently, allowing them to adapt to their distinct tasks more easily. Comparing bats and birds allows for the testing of this idea because they do not share a common flying ancestor and therefore constitute independent replicates to study the evolution of flight. The team measured the wing and leg bones of 111 bat species and 149 bird species from around the world. Their dataset included X-rays of museum specimens and about a third of the new X-rays of bat specimens stored at the Cornell University Museum of Vertebrates. They observed in both bats and birds that the shape of the bones within a species’ wing (handwing, radius, humerus), or within a species’ leg (femur and tibia) are correlated – meaning that within a limb, bones evolve together. However, when looking at the correlation across legs and wings, results are different: Bird species show little to no correlation, whereas bats show strong correlation. This means that, contrary to birds, bats’ forelimbs and hindlimbs did not evolve independently: When the wing shape changes – either increases or shrinks, for example – the leg shape changes in the same direction. Implications for Pterosaur Diversity “We suggest that the coupled evolution of wing and leg limits bats’ capability to adapt to new ecologies,” Hedrick said. The team’s findings raise questions about the evolution of pterosaurs, an extinct group of flying reptiles that had membranous wings similar to those of bats. “Pterosaurs were a lot more diverse than either birds or bats, ranging from tiny insectivores to giraffe-sized Goliaths that rivaled the dinosaurs,” Orkney said. “What was the secret to their evolutionary success?” Ongoing Research in Avian Evolution Following their discovery, the team started re-examining the evolution of bird skeletons in greater depth. “While we showed that the evolution of birds’ wings and legs is independent, and it appears this is an important explanation for their evolutionary success,” Orkney said, “we still don’t know why birds are able to do this or when it began to occur in their evolutionary history.” Reference: “Evolutionary integration of forelimb and hindlimb proportions within the bat wing membrane inhibits ecological adaptation” by Andrew Orkney, David B. Boerma and Brandon P. Hedrick, 1 November 2024, Nature Ecology & Evolution. DOI: 10.1038/s41559-024-02572-9 Some of the measurements for this study were taken at the imaging facility of the Cornell Institute of Biotechnology.

Scientists have constructed an evolutionary timeline for Enterococcus faecalis, a common bacterium known for causing antibiotic-resistant infections in hospital settings. E. faecalis evolved antibiotic resistance before antibiotics were common, driven by agriculture and early medicine, showing remarkable global adaptability. Modern hospitals and antibiotic treatment alone did not create all the antibiotic-resistant strains of bacteria we see today. Instead, selection pressures from before the widespread use of antibiotics influenced some of them to develop, new research has discovered. By using analytical and sequencing technology that has only been developed in recent years, scientists from Wellcome Sanger Institute, University of Oslo and University of Cambridge have created an evolutionary timeline of the bacterium, Enterococcus faecalis, which is a common bacterium that can cause antibiotic-resistant infections in hospitals. The results, published today (March 9th, 2021) in Nature Communications show that this bacterium has the ability to adapt very quickly to selection pressures, such as the use of chemicals in farming as well as the development of new medications, which have caused different strains of the same bacterium to be found in many places worldwide, from the majority of people’s guts to many wild birds. As it is so widespread, the researchers suggest people should be screened for this type of bacteria when entering the hospital, in the same way they are for other superbugs, to help reduce the possibility of developing and spreading infection within healthcare. E. faecalis: From Gut Resident to Global Threat Enterococcus faecalis is a common bacterium that, in most people, is found in the intestinal tract and doesn’t cause harm to the host. However, if someone is immunocompromised and this bacterium gets into the bloodstream, it can cause a serious infection. In hospitals, it is more common to find antibiotic-resistant strains of E. faecalis and it was initially thought that the wide use of antibiotics and other antibacterial control measures in modern hospitals caused these strains to develop. In a new study, scientists from Wellcome Sanger Institute, University of Oslo and University of Cambridge analyzed around 2000 samples of E. faecalis from 1936 to present day using blood stream isolates from patients and stool samples from animals and healthy humans. By sequencing the genome (including chromosomes and plasmids) using technology from Oxford Nanopore, the team mapped the evolutionary journey of the bacterium and created a timeline of when and where different strains developed, including those nowadays found to be resistant to antibiotics. They found that antibiotic-resistant strains developed earlier than previously thought, before the widespread use of antibiotics, and therefore it was not antibiotic use alone that caused these to emerge. Agriculture and Early Medicine Shaped Bacterial Evolution Researchers found that agricultural and early medical practices, such as the use of arsenic and mercury, influenced the evolution of some of the strains we see now. In addition to this, strains similar to the antibiotic-resistant variants we see in hospitals now were found in wild birds. This shows how adaptable and flexible this species of bacterium is at evolving into new strains in the face of different adversity. Professor Jukka Corander, co-lead author and Associate Faculty member at the Wellcome Sanger Institute, said: “This is the first time we have been able to map out the full evolution of E. faecalis from samples up to 85 years old, which enables us to see the detailed effect of human lifestyles, agriculture and medicines on the development of different bacterial strains. Having the full timeline of evolutionary changes would not have been possible without analytical and sequencing techniques that can be found at the Sanger Institute.” Dr. Anna Pöntinen, co-lead author and post-doctoral fellow at University of Oslo, said: “Currently, when patients are admitted to hospital, they are swabbed for some antibiotic-resistant bacteria and fungi and are isolated to ensure that infection rates are kept as low as possible. Thanks to this study, it is possible to scrutinize the diversity of E. faecalis and identify those that are more prone to spread within hospitals and thus could cause harm in immunocompromised people. We believe that it could be beneficial to also screen for E. faecalis on admission to hospitals.” Older Than Expected, More Resilient Than Imagined Professor Julian Parkhill, co-author and Professor in the Department of Veterinary Medicine at University of Cambridge, said: “This research has discovered that these hospital-associated strains of antibiotic-resistant bacteria are much older than we previously thought, and has highlighted their incredible metabolic flexibility combined with numerous mechanisms enhancing their survival under harsh conditions that has allowed them to spread widely across the globe.” Reference: “Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era” by Anna K. Pöntinen, Janetta Top, Sergio Arredondo-Alonso, Gerry Tonkin-Hill, Ana R. Freitas, Carla Novais, Rebecca A. Gladstone, Maiju Pesonen, Rodrigo Meneses, Henri Pesonen, John A. Lees, Dorota Jamrozy, Stephen D. Bentley, Val F. Lanza, Carmen Torres, Luisa Peixe, Teresa M. Coque, Julian Parkhill, Anita C. Schürch, Rob J. L. Willems and Jukka Corander, 9 March 2021, Nature Communications. DOI: 10.1038/s41467-021-21749-5 This research was funded by the Trond Mohn Foundation, the Joint Programming Initiative in Antimicrobial Resistance, the Applied Molecular Biosciences Unit, European Research Council, and Marie Sklodowska-Curie Actions.

DVDV1551RTWW78V