GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Smart pillow ODM manufacturing factory Taiwan
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia anti-odor insole OEM service
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China OEM insole and pillow supplier
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Research reveals that Ohio’s white-tailed deer carry the COVID-19 virus, with the virus variants evolving three times faster in deer than in humans. The implications for potential cross-species transmission in the future remain unclear. Study Finds Deer Are Virus Reservoirs, Promoting Ongoing Mutation New research has found that white-tailed deer across Ohio have been infected with the virus that causes COVID-19. Alarmingly, the results also show that viral variants evolve about three times faster in deer than in humans. Scientists collected 1,522 nasal swabs from free-ranging deer in 83 of the state’s 88 counties between November 2021 and March 2022. More than 10% of the samples were positive for the SARS-CoV-2 virus, and at least one positive case was found in 59% of the counties in which testing took place. Genomic Analysis and Findings Genomic analysis showed that at least 30 infections in deer had been introduced by humans – a figure that surprised the research team. “We generally talk about interspecies transmission as a rare event, but this wasn’t a huge sampling, and we’re able to document 30 spillovers. It seems to be moving between people and animals quite easily,” said Andrew Bowman, associate professor of veterinary preventive medicine at The Ohio State University and co-senior author of the study. “And the evidence is growing that humans can get it from deer – which isn’t radically surprising. It’s probably not a one-way pipeline.” The combined findings suggest that the white-tailed deer species is a reservoir for SARS-CoV-2 that enables continuing mutation, and that the virus’s circulation in deer could lead to its spread to other wildlife and livestock. The study is published today (August 28, 2023) in the journal Nature Communications. Previous Observations and Expansions Bowman and colleagues previously reported detection of SARS-CoV-2 infections in white-tailed deer in nine Ohio locations in December 2021, and are continuing to monitor deer for infection by more recent variants. “We expanded across Ohio to see if this was a localized problem – and we find it in lots of places, so it’s not just a localized event,” Bowman said. “Some of the thought back then was that maybe it’s just in urban deer because they’re in closer contact with people. But in rural parts of the state, we’re finding plenty of positive deer.” Beyond the detection of active infections, researchers also found through blood samples containing antibodies – indicating previous exposure to the virus – that an estimated 23.5% of deer in Ohio had been infected at one time or another. Variant Analysis The 80 whole-genome sequences obtained from the collected samples represented groups of various viral variants: the highly contagious delta variant, the predominant human strain in the United States in the early fall of 2021 that accounted for almost 90% of the sequences, and alpha, the first named variant of concern that had circulated in humans in the spring of 2021. The analysis revealed that the genetic composition of delta variants in deer matched dominant lineages found in humans at the time, pointing to the spillover events, and that deer-to-deer transmission followed in clusters, some spanning multiple counties. “There’s probably a timing component to what we found – we were near the end of a delta peak in humans, and then we see a lot of delta in deer,” Bowman said. “But we were well past the last alpha detection in humans. So the idea that deer are holding onto lineages that have since gone extinct in humans is something we were worried about.” The study did suggest that COVID-19 vaccination is likely to help protect people against severe disease in the event of a spillover back to humans. An analysis of the effects of deer variants on Siberian hamsters, an animal model for SARS-CoV-2 studies, showed that vaccinated hamsters did not get as sick from infection as unvaccinated animals. Rapid Evolution in Deer Disturbingly, the variants circulating in deer are expected to continue to change. An investigation of the mutations found in the samples provided evidence of more rapid evolution of both alpha and delta variants in deer compared to humans. “Not only are deer getting infected with and maintaining SARS-CoV-2, but the rate of change is accelerated in deer – potentially away from what has infected humans,” Bowman said. How the virus is transmitted from humans to white-tailed deer remains a mystery. And so far, even with about 30 million free-ranging deer in the U.S., no substantial outbreaks of deer-origin strains have occurred in humans. Potential Implications Circulation among animals, however, remains highly likely. Bowman noted that about 70% of free-ranging deer in Ohio have not been infected or exposed to the virus, “so that’s a large body of naive animals that the virus could spread through rather uninhibited.” “Having that animal host in play creates things we need to watch out for,” he said. “If this trajectory continues for years and we have a virus that becomes deer-adapted, then does that become the pathway into other animal hosts, wildlife or domestic? We just don’t know.” Reference: “Accelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer” by Dillon S. McBride, Sofya K. Garushyants, John Franks, Andrew F. Magee, Steven H. Overend, Devra Huey, Amanda M. Williams, Seth A. Faith, Ahmed Kandeil, Sanja Trifkovic, Lance Miller, Trushar Jeevan, Anami Patel, Jacqueline M. Nolting, Michael J. Tonkovich, J. Tyler Genders, Andrew J. Montoney, Kevin Kasnyik, Timothy J. Linder, Sarah N. Bevins, Julianna B. Lenoch, Jeffrey C. Chandler, Thomas J. DeLiberto, Eugene V. Koonin, Marc A. Suchard, Philippe Lemey, Richard J. Webby, Martha I. Nelson and Andrew S. Bowman, 28 August 2023, Nature Communications. DOI: 10.1038/s41467-023-40706-y Martha Nelson of the National Library of Medicine was co-corresponding author of the study. Ohio State co-authors Dillon McBride, Steven Overend, Devra Huey, Amanda Williams, Seth Faith and Jacqueline Nolting worked on the study with co-authors from St. Jude Children’s Research Hospital; the University of California, Los Angeles; the National Research Centre in Giza, Egypt; PathAI Diagnostics; the Ohio Department of Natural Resources; the U.S. Department of Agriculture; Columbus and Franklin County Metroparks; and the Rega Institute for Medical Research in Belgium. This work was supported by the National Institute of Allergy and Infectious Diseases and Ohio State’s Infectious Diseases Institute.
Researchers discovered Shishania aculeata, an ancient mollusk dating back 500 million years, in China’s Yunnan Province. Unlike modern mollusks, Shishania lacked a shell and was covered in chitin spines. This find offers unique insights into the early evolution of mollusks, suggesting an armored, slug-like ancestor before the development of shells. The image above depicts the complete specimen of Shishania aculeata seen from the dorsal (top) side (left). Spines covering the body of Shishania aculeata (right). Credit: G Zhang/L Parry The newly discovered fossil of Shishania aculeata, an early mollusk without a shell but covered in protective spines, offers new insights into molluscan evolution, indicating a primitive, slug-like form during the Cambrian period. Researchers have discovered a new species of mollusk that lived 500 million years ago. The new fossil, called Shishania aculeata, reveals that the most primitive mollusks were flat, shell-less slugs covered in a protective spiny armor. The findings were recently published in the journal Science. Unveiling Prehistoric Molluscan Life Shishania aculeata was found in exceptionally well-preserved fossils from eastern Yunnan Province in southern China dating from a geological Period called the early Cambrian, approximately 514 million years ago. The specimens of Shishania are all only a few centimeters long and are covered in small spikey cones (sclerites) made of chitin, a material also found in the shells of modern crabs, insects, and some mushrooms. Specimens that were preserved upside down show that the bottom of the animal was naked, with a muscular foot like that of a slug that Shishania would have used to creep around the seafloor over half a billion years ago. Unlike most mollusks, Shishania did not have a shell that covered its body, suggesting that it represents a very early stage in molluscan evolution. Conical spines that cover the body of Shishania aculeata (left). Electron microscope image of a conical spine showing the microscopic channels preserved inside (right). Credit: G Zhang/L Parry Modern molluscs have a dizzying array of forms and include snails, clams, and even highly intelligent groups such as squids and octopuses. This diversity of molluscs evolved very rapidly a long time ago, during an event known as the Cambrian Explosion when all the major groups of animals were rapidly diversifying. This rapid period of evolutionary change means that few fossils have been left behind that chronicle the early evolution of mollusks. “Trying to unravel what the common ancestor of animals as different as a squid and oyster looked like is a major challenge for evolutionary biologists and paleontologists – one that can’t be solved by studying only species alive today. Shishania gives us a unique view into a time in mollusk evolution for which we have very few fossils, informing us that the very earliest mollusk ancestors were armored spiny slugs, prior to the evolution of the shells that we see in modern snails and clams,” said Corresponding author Associate Professor Luke Parry, Department of Earth Sciences, University of Oxford. Artist’s reconstruction of Shishania aculeata as it would have appeared in life as viewed from the top, side, and bottom (left to right). Credit: M. Cawthorne Detailed Analysis of Shishania’s Structure Because the body of Shishania was very soft and made of tissues that aren’t typically preserved in the fossil record, the specimens were challenging to study, as many of the specimens were poorly preserved. First author Guangxu Zhang, a recent PhD graduate from Yunnan University in China who discovered the specimens said: “At first I thought that the fossils, which were only about the size of my thumb, were not noticeable, but I saw under a magnifying glass that they seemed strange, spiny, and completely different from any other fossils that I had seen. I called it “the plastic bag” initially because it looks like a rotting little plastic bag. When I found more of these fossils and analyzed them in the lab I realized that it was a mollusk.” Parry added: “We found microscopic details inside the conical spines covering the body of Shishania that show how they were secreted in life. This sort of information is incredibly rare, even in exceptionally preserved fossils.” The spines of Shishania show an internal system of canals that are less than a hundredth of a millimeter in diameter. These features show that the cones were secreted at their base by microvilli, tiny protrusions of cells that increase surface area, such as in our intestines where they aid food absorption. Evolutionary Insights from Shishania Fossils This method of secreting hard parts is akin to a natural 3D printer, allowing many invertebrate animals to secrete hard parts with huge variations of shape and functions from providing defense to facilitating locomotion. Hard spines and bristles are known in some present-day mollusks (such as chitons), but they are made of the mineral calcium carbonate rather than organic chitin as in Shishania. Similar organic chitinous bristles are found in more obscure groups of animals such as brachiopods and bryozoans, which together with mollusks and annelids (earthworms and their relatives) form the group Lophotrochozoa. Parry added: “Shishania tells us that the spines and spicules we see in chitons and aplacophoran mollusks today actually evolved from organic sclerites like those of annelids. These animals are very different from one another today and so fossils like Shishania tell us what they looked like deep in the past, soon after they had diverged from common ancestors.” Co-author Jakob Vinther at the University of Bristol said: “Molluscs today are extraordinarily disparate and they diversified very quickly during the Cambrian Explosion, meaning that we struggle to piece together their early evolutionary history. We know that the common ancestor of all mollusks alive today would have had a single shell, and so Shishania tells us about a very early time in mollusk evolution before the evolution of a shell.” Co-corresponding author Xiaoya Ma (Yunnan University and University of Exeter) said: “This new discovery highlights the treasure trove of early animal fossils that are preserved in the Cambrian rocks of Yunnan Province. Soft bodied mollusks have a very limited fossil record, and so these very rare discoveries tell us a great deal about these diverse animals.” Reference: “A Cambrian spiny stem mollusk and the deep homology of lophotrochozoan scleritomes” by Guangxu Zhang, Luke A. Parry, Jakob Vinther and Xiaoya Ma, 1 August 2024, Science. DOI: 10.1126/science.ado0059
A collaborative study reveals that the cerebellar nuclei play a crucial role in associative learning, challenging previous beliefs that focused on the cerebellar cortex. Through innovative techniques like optogenetics and electrical cell measurements, the research shows how these nuclei contribute to learning processes, with implications for human neuroscience. Our Cerebellar Nuclei Are More Important Than Initially Thought Associative learning was always thought to be regulated by the cortex of the cerebellum, often referred to as the “little brain”. However, new research from a collaboration between the Netherlands Institute for Neuroscience, Erasmus MC, and Champalimaud Center for the Unknown reveals that actually the nuclei of the cerebellum make a surprising contribution to this learning process. Understanding Associative Learning If a teacup is steaming, you’ll wait a bit longer before drinking from it. And if your fingers get caught in the door, you’ll be more careful next time. These are forms of associative learning, where a positive or negative experience leads to learning behavior. We know that our cerebellum is important in this form of learning. But how exactly does this work? Research Methodology To investigate this issue, an international team of researchers in the Netherlands and Portugal, consisting of Robin Broersen, Catarina Albergaria, Daniela Carulli, with Megan Carey, Cathrin Canto, and Chris de Zeeuw as senior authors, looked at the cerebellum of mice. The researchers trained mice with two different stimuli: a brief flash of light, followed by a gentle puff of air to the eye. Over time, the mice learned that there was an association between the two, leading them to pre-emptively close their eyes when they saw the flash of light. This behavioral paradigm has been used for many years to explore how the cerebellum works. The Cerebellum’s Structure and Function If you look at the cerebellum, you can distinguish two major parts in it: the cerebellar cortex, or the outer layer of the cerebellum, and the cerebellar nuclei, the inner part. These parts are interconnected. The nuclei are groups of brain cells that receive all kinds of information from the cortex. These nuclei in turn have connections to other brain areas that control movements, including eyelid closures. Essentially, the nuclei are the output center of the cerebellum. An artistic interpretation of the research. The bright algae represent mossy fibers — brain connections that interact with pufferfish, symbolizing the cerebellar nuclei cells that respond variably to stimuli. The boat’s timber patterns above suggest the structure of the cerebellar cortex, linked to the depths by an anchor line, portraying the connection between the cortex and nuclei. Credit: Rita Félix Robin Broersen: “The cerebellar cortex has long been regarded as the primary player in learning the reflex and timing of the eyelid closure. With this study, we show that well-timed eyelid closures can also be regulated by the cerebellar nuclei. Both laboratories were working on similar research topics and when we realized the synergy of our work, we decided to start an international collaboration resulting in the present article.” The cerebellum is influenced by other brain regions via different connections, the so-called mossy fibers and the climbing fibers. In the experiment described above, it is thought that the mossy fibers carry information from the light, and that the climbing fibers convey information related to the air puff. This information then converges in the cortex and nuclei of the cerebellum. The Dutch team investigated the effect of associative learning on these connections to the nuclei and found that the mossy fibers had made stronger connections to the nuclei in the mice showing associative learning. Activation With Light Meanwhile, the Portuguese team tested the capacity for learning in the cerebellar nuclei using optogenetics — a method that uses light to control cells. Catarina Albergaria: “Instead of using a regular light flash to train mice, we directly stimulated brain connections with light while pairing it with an air puff to the eye. This caused the mice to close their eyelids at the right times, showing that the cerebellar nuclei can support well-timed learning. To ensure this learning was actually happening in the nuclei, we repeated the experiments in mice with an inactivated cerebellar cortex.” Cathrin Canto: “While learning, connections between brain cells change. Still, it wasn’t clear where in the cerebellum these changes were taking place. Therefore, we looked at what happens to the mossy fibers and connections from the cortex while learning. We found that in mice that learned — but not ones that didn’t — the connections from the mossy fibers and from the cortex to the nuclei became stronger.” State-of-the-Art Technology Canto continues: “We also visualized what happens inside the cell, by taking electrical measurements inside the nuclear cells of a living mouse. You can imagine that these cells are very small, 10 to 20 µm. That’s smaller than the diameter of a human hair. Using an ultra-thin tube with an electrode, we were able to record the electrical activity inside the cells while the mouse performed the task, an enormous technical challenge.” “In trained animals, light exposure caused the electrical activity inside the nucleus cells to change: the cells became more active the closer you got to the air puff in terms of timing. Essentially, the cells were prepared for what was to come and could therefore make their electrical activity precise enough to control the eyelid even before the puff had taken place.” Mouse Versus Human Broersen: “Although this research uses mice, the general anatomy of the cerebellum is similar between mice and humans. While humans have many more cells, we expect the connections between cells to be organized in the same way. “Our results contribute to a better understanding of how the cerebellum works and what happens during the learning process. This also leads to more knowledge about how damage to the cerebellum affects functioning, which may help patients in the future. By stimulating the connections to the nuclei using deep brain stimulation, it might be possible to learn new motor skills.” Reference: “Synaptic mechanisms for associative learning in the cerebellar nuclei” by Robin Broersen, Catarina Albergaria, Daniela Carulli, Megan R. Carey, Cathrin B. Canto and Chris I. De Zeeuw, 20 November 2023, Nature Communications. DOI: 10.1038/s41467-023-43227-w
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