|
|
文章數：235 |
 一頭牛日式燒肉飲料值得加點嗎？》台中公益路高人氣餐廳推薦｜10家好吃又好拍 |
| 心情隨筆｜心情日記 2026/04/22 08:17:53 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： TANG Zhan 湯棧好吃嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。NINI 尼尼臺中店會太油嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。永心鳳茶氣氛如何？ 下一餐，不妨從這10家開始。NINI 尼尼臺中店適合跨年聚餐嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。NINI 尼尼臺中店價格合理嗎？ 如果你有私心愛店，也歡迎留言分享，TANG Zhan 湯棧有提供尾牙方案嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。茶六燒肉堂用餐環境舒服嗎？ The spread of 46 human chromosomes measured using X-rays in the study, with color added. Credit: Archana Bhartiya et al/ Chromosome Research The mass of human chromosomes, which contain the instructions for life in nearly every cell of our bodies, has been measured with X-rays for the first time in a new study led by University College London (UCL) researchers. For the study, published in Chromosome Research, researchers used a powerful X-ray beam at the UK’s national synchrotron facility, Diamond Light Source, to determine the number of electrons in a spread of 46 chromosomes which they used to calculate mass. They found that the chromosomes were about 20 times heavier than the DNA they contained – a much larger mass than previously expected, suggesting there might be missing components yet to be discovered. As well as DNA, chromosomes consist of proteins that serve a variety of functions, from reading the DNA to regulating processes of cell division to tightly packaging two-meter strands of DNA into our cells. Senior author Professor Ian Robinson (London Centre for Nanotechnology at UCL) said: “Chromosomes have been investigated by scientists for 130 years but there are still parts of these complex structures that are poorly understood. “The mass of DNA we know from the Human Genome Project, but this is the first time we have been able to precisely measure the masses of chromosomes that include this DNA. “Our measurement suggests the 46 chromosomes in each of our cells weigh 242 picograms (trillionths of a gram). This is heavier than we would expect, and, if replicated, points to unexplained excess mass in chromosomes.” In the study, researchers used a method called X-ray ptychography, which involves stitching together the diffraction patterns that occur as the X-ray beam passes through the chromosomes, to create a highly sensitive 3D reconstruction. The fine resolution was possible as the beam deployed at Diamond Light Source was billions of times brighter than the Sun (ie, there was a very large number of photons passing through at a given time). The chromosomes were imaged in metaphase, just before they were about to divide into two daughter cells. This is when packaging proteins wind up the DNA into very compact, precise structures. Archana Bhartiya, a PhD student at the London Centre for Nanotechnology at UCL and lead author of the paper, said: “A better understanding of chromosomes may have important implications for human health. “A vast amount of study of chromosomes is undertaken in medical labs to diagnose cancer from patient samples. Any improvements in our abilities to image chromosomes would therefore be highly valuable.” Each human cell, at metaphase, normally contains 23 pairs of chromosomes, or 46 in total. Within these are four copies of 3.5 billion base pairs of DNA. Reference: “X-ray Ptychography Imaging of Human Chromosomes After Low-dose Irradiation” by Archana Bhartiya, Darren Batey, Silvia Cipiccia, Xiaowen Shi, Christoph Rau, Stanley Botchway, Mohammed Yusuf and Ian K. Robinson, 31 March 2021, Chromosome Research. DOI: 10.1007/s10577-021-09660-7 The research was supported by Diamond Light Source, UKRI, the Biotechnology and Biological Sciences Research Council (BBSRC), the Engineering and Physical Sciences Research Council (EPSRC), the European Research Council, and the US Department of Energy. Scientists have discovered a brain gene linked to anxiety symptoms, offering a potential new drug target. They found that a molecule, miR483-5p, suppresses another gene, Pgap2, which causes anxiety-related changes in the brain, suggesting a potential mechanism for anxiety relief. This discovery could lead to more effective treatments for anxiety disorders. An international team of scientists has identified a gene in the brain linked to anxiety symptoms, with modifications to this gene shown to reduce anxiety levels. A gene in the brain driving anxiety symptoms has been identified by an international team of scientists. Critically, modification of the gene is shown to reduce anxiety levels, offering an exciting novel drug target for anxiety disorders. The discovery, led by researchers at the Universities of Bristol and Exeter, was published on April 25 in the journal Nature Communications. Anxiety disorders are common with 1 in 4 people diagnosed with a disorder at least once in their lifetime. Severe psychological trauma can trigger genetic, biochemical, and morphological changes in neurons in the brain’s amygdala — the brain region implicated in stress-induced anxiety, leading to the onset of anxiety disorders, including panic attacks and post-traumatic stress disorder. However, the efficacy of currently available anti-anxiety drugs is low with more than half of patients not achieving remission following treatment. Limited success in developing potent anxiolytic (anti-anxiety) drugs is a result of our poor understanding of the neural circuits underlying anxiety and molecular events resulting in stress-related neuropsychiatric states. Uncovering Molecular Events Behind Anxiety In this study, scientists sought to identify the molecular events in the brain that underpin anxiety. They focused on a group of molecules, known as miRNAs in animal models. This important group of molecules, also found in the human brain, regulates multiple target proteins controlling the cellular processes in the amygdala. Following acute stress, the team found an increased amount of one type of molecule called miR483-5p in a mouse amygdala. Importantly, the team showed that increased miR483-5p suppressed the expression of another gene, Pgap2, which in turn drives changes to neuronal morphology in the brain and behavior associated with anxiety. Together, the researchers showed that miR-483-5p acts as a molecular brake that offsets stress-induced amygdala changes to promote anxiety relief. The discovery of a novel amygdala miR483-5p/Pgap2 pathway through which the brain regulates its response to stress is the first stepping stone towards the discovery of novel, more potent, and much-needed treatments for anxiety disorders that will enhance this pathway. Dr. Valentina Mosienko, one of the study’s lead authors and an MRC Fellow and Lecturer in Neuroscience in Bristol’s School of Physiology, Pharmacology and Neuroscience, said: “Stress can trigger the onset of a number of neuropsychiatric conditions that have their roots in an adverse combination of genetic and environmental factors. While low levels of stress are counterbalanced by the natural capacity of the brain to adjust, severe or prolonged traumatic experiences can overcome the protective mechanisms of stress resilience, leading to the development of pathological conditions such as depression or anxiety. “miRNAs are strategically poised to control complex neuropsychiatric conditions such as anxiety. But the molecular and cellular mechanisms they use to regulate stress resilience and susceptibility were until now, largely unknown. The miR483-5p/Pgap2 pathway we identified in this study, activation of which exerts anxiety-reducing effects, offers a huge potential for the development of anti-anxiety therapies for complex psychiatric conditions in humans.” Reference: “miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala” by Mariusz Mucha, Anna E. Skrzypiec, Jaison B. Kolenchery, Valentina Brambilla, Satyam Patel, Alberto Labrador-Ramos, Lucja Kudla, Kathryn Murrall, Nathan Skene, Violetta Dymicka-Piekarska, Agata Klejman, Ryszard Przewlocki, Valentina Mosienko and Robert Pawlak, 25 April 2023, Nature Communications. DOI: 10.1038/s41467-023-37688-2 The research was funded by the Medical Research Council, Academy of Medical Sciences, Leverhulme Trust, Marie Sklodowska-Curie, and the Polish National Science Centre. Geneticists have conducted research to understand the genetic origins of skin pigmentation variations among different ethnicities, revealing that genes associated with East Asian and Native American ancestry are responsible for their lighter skin tones. This discovery provides insights into skin cancer prevention and treatment, as Europeans with similar skin tones have higher melanoma rates. The Discovery Could Have Implications for the Prevention of Certain Skin Cancers A team of Penn State geneticists is pursuing the answers to an age-old question of human biology: the genetic origin of fundamental variations in skin pigmentation between people of different ethnicities. The link between skin pigmentation and ethnicity is more complicated than previously believed, according to a recent study published in the journal eLife. The team has confirmed that genes associated with East Asian and Native American ancestry, rather than the genes underpinning lighter skin in people with European ancestry, explain the lighter skin of people of East Asian and Native American descent. Learning what genes are responsible for regulating skin tone, depending on a person’s ancestral origin, has broad implications for genetic research, according to the team, especially as it relates to preventing or treating certain skin cancers. “We’re a step closer to laying a foundation for understanding where we came from, how color change occurs molecularly, and why skin color change is more associated with sun-induced melanoma in Europeans,” said co-corresponding author Keith C. Cheng, distinguished professor of pathology and laboratory medicine, of biochemistry and molecular biology, and of pharmacology at Penn State. Nurses in the Kalinago community traveled with the researchers to connect with more distant members of the tribe and to assist in data collection. Credit: Khai C. Ang A key clue to understanding the evolution of human skin tones resides in the genome of a small population in the Commonwealth of Dominica, according to Cheng. Situated a two-hour ferry ride north of the popular island of Martinique, the tiny, rocky island of Dominica is home to the Kalinago people, who have the least European ancestry of any Native American population in the Caribbean. Cheng first connected with the tribe — whose ancestry comprises primarily Native American and African lines — 15 years ago, after his lab identified the gene responsible for lighter skin color in Europeans. The National Institutes of Health provided the initial funds in 2009 for Cheng and co-corresponding author Khai C. Ang to work with the geographically and genetically isolated Kalinago people to rule out the possibility that the same gene also regulates skin tone in Native Americans and East Asians. “After identifying the variant of the gene SLC24A5, the primary contributor to lighter skin color in Europeans in 2005, the next obvious question was: what about similar skin tones in Native Americans and East Asians?” said Cheng, who led the team that made this discovery. “Both populations are relatively light-skinned, but Europeans are at least 15 times more likely to get melanoma. Why don’t East Asians and Native Americans experience skin cancer at the same rate?” The Science of Skin Color “Skin color differences have long been a mystery of human biology,” said Ang, assistant professor of pathology and laboratory medicine at Penn State. All humans originated in Africa, and as they expanded their footprint to the rest of the world, two main migration branches emerged: the European branch, which includes peoples on the Indian subcontinent and Europe, and the East Asian branch, which includes East Asia and the Americas. People in both branches adapted to geographically and climatically different areas. One such adaptation involved melanin, the cellular pigment responsible for darker tones in skin, hair, and eyes. It offers some protection from sunlight’s ultraviolet (UV) rays, which can damage skin cells. But in the northern latitudes of Europe and Asia, melanin also limits the production of vitamin D, which is critical to human health, Ang said. Penn State researchers spent 15 years working with the Kalinago people in the Caribbean to better understand the genetics underpinning skin tone in people without significant European ancestry. Credit: Khai C. Ang “A biological benefit of sunlight is vitamin D, which the body produces from UV exposure,” Ang said. “In places with lower UV rays, people with less melanin make better use of whatever exposure they have.” For this reason, both Native Americans and East Asians appear to have less melanin than people with African ancestry, but they are less likely than Europeans to develop melanoma, according to Ang. “There are multiple modifications in the human genome that can influence skin tones, but humans have historically been classified by ancestry into three major groups: African, Native American/East Asian and European/South Asian,” Ang said. “European skin is more sensitive to UV damage despite having similar shades as East Asians and Native Americans. Some cellular and genetic mechanism must protect against such damage.” Now that the team has confirmed that different genes are responsible for skin tones in each migration branch of humanity, Cheng said, researchers can begin to better understand why the European mechanism of lighter skin results in higher rates of melanoma among Europeans. “This work confirms that separate genetic mechanisms were involved in the evolution of lighter skin in each of the human migration branches,” Cheng said. The Kalinago Collaboration The work was more involved than simply testing genes, though, according to the researchers. The Kalinago people were, Cheng said, “rightfully guarded before generously participating in this work.” “I went into this with a naïve, idealistic perspective — that science could benefit everyone, including this group,” Cheng said, noting that he quickly learned that many Kalinago had good reason to be skeptical. “Scientists have worked with populations like this before without benefitting them. The Kalinago people’s history of contact with the European world was fraught with colonialism. One can’t blame them for being suspicious.” Cheng, Ang, and their collaborators spent more than a decade building relationships with the Kalinago people and their leadership. Kalinago councils comprising elected officials oversee the community. New elections every few years meant that the researchers had to earn tribal buy-in with every leadership change. The Kalinago people live on Dominica, a small island in the Caribbean. Credit: Khai C. Ang “We had and continue to have discussions with the Kalinago Council and nurses in the community about the project and how they potentially can help solve of the mysteries of human skin pigmentation, emphasizing their contribution to science,” Ang said. “And they agreed to help. That was amazing.” The researchers made multiple data-collection trips, led by Ang, to Dominica, spending up to four months at a time with the Kalinago. While the tribe members speak English, they primarily converse in Creole. The researchers closely collaborated with Kalinago nurses, who traveled with them to the farthest reaches of the island, helping to collect saliva and skin shade measurements and to make the study participants more comfortable. In exchange, the researchers, who learned some conversational Kalinago, volunteered in the Kalinago clinic. “We earned a few small grants — including one from the Hershey Rotary Club — to buy medical equipment to donate,” Ang said. Cheng noted that the team also provided the community with satellite equipment, which became their main means of communication after Hurricane Maria in 2017. The symbiotic relationship reflected the researchers’ scientific intentions, the researchers said. “We’re looking at these tiny changes in DNA — biology that underpins all humans,” Ang said. “And no matter what our ancestry is, we’re all human and we’re all curious. We and the Kalinago worked together to understand this genetic mystery of our skin color.” Matters of Melanin The researchers suspected the Kalinago people have little European ancestry from their history, and they confirmed that they only have about 12% European genetics. “With this confirmation, we knew that we could use data from this population to focus on origins of lighter pigmentation that appears to have most likely come from shared ancestors in East Asia,” Cheng said. All humans have the same set of about 20,000 genes, but individuals carry different combinations of these genes, called alleles. Common combinations of gene alleles define a person’s ancestry — these are the maps that enable such genetic ancestry services as 23andMe to track individual ancestral history. Most alleles differ in subtle ways, such as the single letter change in SLC24A5 that is largely responsible for European peoples’ shared lighter skin color. “Combinations of those alleles define ancestry and make a huge impact on skin color,” Cheng said. “We all carry mutant forms of skin color genes, or alleles, that result in our individual skin tones. Skin color alleles program a person’s skin to have more or less melanin.” Ang measured each participant’s skin melanin by using a reflectometry device on their inner upper arm. The device flashes light and measures the amount of light reflection; darker skin, which has more melanin, reflects less light than lighter skin. These values are then studied quantitatively as melanin index units — the higher the value, the darker the skin. Ang also collected saliva samples to study each participant’s DNA. In total, the team collected measurements and samples from 458 people, or about 15% of the Kalinago population, including three people with albinism. They analyzed genetic ancestry and sequenced about three million markers for skin tone from each sample. “We found that Native American/East Asian ancestry alone contributed at least 20 melanin units,” Ang said. “For comparison, each European mutation, and the albinism allele we identified, contributed between -4 and -8 melanin units. It turns out that none of the published candidates for Native American/East Asian skin-lightening genes caused a detectable effect.” Overall, the researchers determined that the Kalinago people have more Native American ancestry — about 55% — and less European genetic ancestry — about 12% — than any other Caribbean population. About 32% of their ancestry is African. The melanin index measurements and genetic analysis also matched with the Kalinago’s oral histories, according to the researchers, in which participants reported “Black,” “Kalinago” or “mixed” heritage. “We now know that already identified pigmentation gene candidates are not responsible for skin color in this population,” Cheng said. “That means this population may help us to discover what genes are really responsible for the lighter skin of Native Americans and East Asians.” Reference: “Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population” by Khai C Ang, Victor A Canfield, Tiffany C Foster, Thaddeus D Harbaugh, Kathryn A Early, Rachel L Harter, Katherine P Reid, Shou Ling Leong, Yuka Kawasawa, Dajiang Liu, John W Hawley and Keith C Cheng, 9 June 2023, eLife. DOI: 10.7554/eLife.77514 Other project collaborators from the Penn State College of Medicine include Rachel L. Harter, Department of Pathology; Victor A. Canfield, Tiffany C. Foster, Thaddeus D. Harbaugh, Kathryn A. Early and Katherine P. Reid, all with the Department of Pathology and the Jake Gittlen Laboratories for Cancer Research; Shou Ling Leong, Department of Family & Community Medicine; Yuka Kawasawa, Departments of Biochemistry and Molecular Biology and of Pharmacology, and the Institute of Personalized Medicine; and Dajiang Liu, Departments of Biochemistry and Molecular Biology and of Public Health Sciences. The late John W. Hawley of the Salybia Mission Project in Dominica also participated. The National Institutes of Health’s National Institute of Arthritis and Musculoskeletal and Skin Diseases, the Cheng Family, the Penn State College of Medicine’s Jake Gittlen Laboratories for Cancer Research and Department of Pathology, the Hershey Rotary Club and Microryza also supported this research. RRG455KLJIEVEWWF |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 最新創作 |
|
||||
|
||||
|
||||
|
||||
|
||||
