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文章數：34 |
 一笈壽司春酒場面夠體面嗎？》台中公益路美食推薦｜精選10家不踩雷餐廳 |
| 創作｜小說 2026/05/20 04:26:54 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 三希樓適合辦部門小聚嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。茶六燒肉堂飲料值得加點嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。KoDō 和牛燒肉好吃嗎？ 下一餐，不妨從這10家開始。KoDō 和牛燒肉慶生氣氛夠嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。加分100%浜中特選昆布鍋物飲料值得加點嗎？ 如果你有私心愛店，也歡迎留言分享，TANG Zhan 湯棧口味偏臺式還是日式？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。KoDō 和牛燒肉用餐環境舒服嗎？ Researchers discovered that the J chain, a key component of the immune system that stabilizes certain antibodies, originally came from the CXCL chemokine gene family. This finding sheds light on the evolutionary adaptation of the immune system and has potential implications for developing personalized immune therapies. Credit: SciTechDaily.com The human immune system appears to have evolutionarily co-opted a molecule from another biological process. Researchers discovered that a protein called the J chain, which helps the immune system function properly, originally came from a different family of genes known as CXCL chemokines. Published in the Proceedings of the National Academy of Sciences, their findings help us better understand how the immune system works and could lead to new ways to treat diseases. Evolution and Adaptation in Immune Proteins In several ways, biological systems can behave as siblings, including by borrowing something and never giving it back. That appears to be what the human immune system did with a protein that now helps bind and regulate the subunits that make up antibodies, according to a multi-institute research collaboration. They found that, before the immune system evolutionarily co-opted it, the protein originally belonged to the gene family responsible for directing cells to move to the right location at the right time to address specific functional needs. The researchers, including Kazuhiko Kawasaki, associate research professor of anthropology at Penn State, published their findings in the Proceedings of the National Academy of Sciences. According to the team, while this work primarily informs a fundamental understanding of one feature of the immune system and associated genes, it may also help open design pathways future therapeutics, such as personalized immune responses. Discovering the Origins of the J Chain “Everything comes from somewhere, and we believe we found the origin of immunoglobin Joining chain (J chain), an important immune molecule,” said corresponding author Martin F. Flajnik, department of microbiology and immunology, University of Maryland, who led the study. Flajnik also earned his undergraduate degree in biology from Penn State in 1978 before completing his graduate degrees at the University of Rochester. The J chain assembles and stabilizes two types of antibodies, called immunoglobin M (IgM) and immunoglobin A (IgA). It specifically regulates the structures of the IgM and IgA molecules, which have several subunits, and is required for their movement across the mucus-producing tissue lining body structures with external exposure, like the intestine, nasal cavity, and lungs. The researchers found that the J chain originated from the CXCL chemokines, a specific family of proteins that regulate the ability of white blood cells to move throughout the body. Gene Evolution and Mystery of J Chain “Like immunoglobin itself and human-like adaptive immunity, the J chain emerged in jawed vertebrates, but its origin has remained mysterious since its discovery over 50 years ago,” Flajnik said. “This finding was never anticipated. Chemokine-driven locomotion is a vital function of the immune system, but a totally different function as compared to the J chain!” Evolutionarily, new genes are often generated from genes that reside physically close together on the chromosome, and those genes typically remain clustered together even as they evolve different yet similar functions, but Kawasaki said location isn’t the only deciding factor to determine origin. Investigating Gene Similarities and Future Research Directions “The evolutionary relationship of genes can usually be detected when two genes retain similar nucleotide sequences or encoded amino acid sequences,” Kawasaki said, referring to the materials comprising an organism’s genetic code. “But previous studies could not detect any genes that show sequence similarities to the J chain gene, probably because the J chain gene sequence was quickly changed at its origin.” Flajnik said he had a hunch that the J chain was related to a group of secretory calcium-binding phosphoprotein (SCPP) genes due to their similar charges and levels of proline, an amino acid. He knew Kawasaki was an expert on SCPP genes, so he emailed him to assess the idea. “He told me that, for various good reasons, the SCPPs and J chain were not related,” Flajnik said. “That was sad, as it was my favorite hypothesis.” The Joining chain shares three characteristics with the CXCL chemokine genes, including the same number of exons, which encode the protein, and phases of introns, which act as interrupters to stop or start splicing of the RNA molecules transcribed from the gene. The second exon encodes the same sequence, which is known as the classical tripeptide Cysteine-X-Cysteine, for both genes. The lengths of three of the exons are also similar. Credit: Martin F. Flajnik and Kazuhiko Kawasaki However, Kawasaki had noticed that genes on the opposite side of the J chain gene, away from the SCPP genes, did appear to be related to the J chain. Those were the CXCL chemokine genes. “I immediately checked these CXCL chemokine genes and found that, though these genes do not show sequence similarities to the J chain genes, these genes and the J chain gene resemble each other with other various characteristics,” Kawasaki said. Those characteristics include the same number of exons, which encode the protein, and phases of introns, which act as interrupters to stop or start splicing of the RNA molecules transcribed from the gene. The second exon encodes the same sequence, which is known as the classical tripeptide Cysteine-X-Cysteine, for both genes. The lengths of three of the exons are also similar. “No other gene encoding the human secretome, which encompasses all proteins that can be secreted by cells of an organism, shares all three characteristics,” Kawasaki said. The bonds between the Cysteine molecules encoded by the second exon in each gene are completely different from one another, though, the researchers said. “This means that a chemokine can change its structure, to a large extent, and take on a new function,” Flajnik said. Next, the researchers said they plan to investigate if chemokines have taken on other functions, specifically in the immune system. They also want to study if chemokines are pliable in their structure, which could indicate the ability to take on an entirely new secondary structure, adapting in response to different biological needs as required. “I’ve been around for a long time, for 44 years in science, but this experience was one of the most incredibly satisfying and lucky,” Flajnik said. “I doubt that this similarity would have been uncovered for a long time without the serendipitous interaction between Kazuhiko and me.” Reference: “The immunoglobulin J chain is an evolutionarily co-opted chemokine” by Kazuhiko Kawasaki, Yuko Ohta, Caitlin D. Castro and Martin F. Flajnik, 12 January 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2318995121 Other co-authors include Yuko Ohta, assistant professor of microbiology and immunology at the University of Maryland, and Caitlin D. Castro, a research fellow in the Department of Biochemistry and Molecular Biology at the University of Chicago. The National Institutes of Health supported this research. Spatial and temporal memory are two forms of memory that are critical for navigation and everyday life. Spatial memory refers to the ability to remember the location of objects and events in space, while temporal memory involves the ability to recall the timing and sequence of events. Through a series of experiments, researchers evaluated individuals’ ability to recall the location and timing of an object – spatial and temporal memory, respectively – and found both to be massive. Don’t despair the next time you forget where you placed your keys, parked your car, or set down your glasses. Previous research has shown that if individuals are shown a large number of objects, they are very good at subsequently remembering which objects they have seen. A recent study suggests that people are also shockingly skilled at remembering where and when they saw those objects In a series of experiments conducted by investigators from Brigham and Women’s Hospital, a member of the Mass General Brigham healthcare system, participants were able to recall the location of over 100 items when shown on a 7-by-7 grid, accurately selecting the right location or a cell adjacent to it. The results, published in Current Biology, demonstrate that people possess “spatial massive memory” (SMM) for the location of objects and “temporal massive memory” (TMM) for the timing of when objects were last seen. To conduct their study, Wolfe and colleagues asked participants to remember a number of objects placed on a 7-by-7 grid. Each item was highlighted for two seconds by placing a red square around it. After participants were shown the items, all of the images were removed and the participants were then tested on their ability to recall if they had seen an item before and, if so, where it had been located on the grid. Credit: Brigham and Women’s Hospital “People often think that their memory is terrible, but our results show that we can recall where and when an object appeared with good, if not perfect, precision for a large number of objects,” said corresponding author Jeremy Wolfe, Ph.D., of the Brigham’s Department of Surgery. “While our spatial and temporal memory for objects may not be as impressive as some birds or squirrels, who have to remember where they hid their food for the winter, our data show that we do have massive memory for objects.” To conduct their study, Wolfe and colleagues asked participants to remember a number of objects placed on a 7-by-7 grid. Each item was highlighted for two seconds by placing a red square around it. After participants were shown the items, all of the images were removed and the participants were then tested on their ability to recall if they had seen an item before and, if so, where it had been located on the grid. “In some ways, this is a bit like the game of Memory that many of us played as children, where we turned over a card and then tried to recall the location of a matching card that we had seen before,” said Wolfe. “But unlike in the children’s game, we didn’t just count the exact ‘correct’ answer. We measured how close the participant got to the previously seen image.” Surprising Accuracy in Location and Timing Altogether observers saw 300 different objects. Many observers could localize over 100 items to within +/- one cell of the true object location. In a subsequent experiment, participants were shown items one at a time and were asked to click on a timeline, present on the screen, to indicate when they had seen the object. The researchers reported that participants localized 60-80% of old items to within +/-10% of their correct time, markedly better than the 40% that they could have gotten by guessing. The authors note that further experiments would be needed to define the upper limits of massive memory or to investigate other topics such as possible gender effects on memory. Wolfe explains that some things slide into our long-term memory far more easily than others—understanding what we can remember most easily, such as pictures of objects and scenes, could help us make the most of our memory. Enhancing Memory Through Object and Scene Recall “Since ancient times, people have been using memory tricks related to our ability to remember pictures and scenes to help encode large amounts of information to store in their minds. In that sense, it’s not terribly surprising that, using our methods, we discover that we’re pretty good at remembering where objects are,” said Wolfe. “Our experiments show that spatial and temporal massive memories exist. Future research will define their limits.” Reference: “Spatial and temporal massive memory in humans” by Jeremy M. Wolfe, Farahnaz A. Wick, Maruti Mishra, Joseph DeGutis, and Wanyi Lyu, 23 January 2023, Current Biology. DOI: 10.1016/j.cub.2022.12.040 Researchers have made significant advances in understanding synapse formation. They used CRISPR technology to observe synaptic vesicle development and discovered that synaptic components share a common transport pathway. This finding, coupled with the discovery of unique neuronal transport organelles, offers new insights into neuronal functions and potential therapeutic approaches for neurological damage. Whether in the brain or in the muscles, synapses are present wherever nerve cells exist. Synapses, the connections between neurons, are fundamental to the process of excitation transmission, which is essentially communication between neurons. As in any communication process, there is a sender and a receiver: Nerve cell processes called axons generate and transmit electrical signals thereby acting as signal senders. Synapses are points of contact between axonal nerve terminals (the pre-synapse) and post-synaptic neurons. At these synapses, the electrical impulse is converted into chemical messengers that are received and sensed by the post-synapses of the neighboring neuron. The messengers are released from special membrane sacs called synaptic vesicles. As well as transmitting information, synapses can also store information. While the structure and function of synapses are comparably well understood, little is known about how they are formed. A team from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin has now shed significant light on this mystery. Scientists from Charité-Universitätsmedizin, the Max Delbrück Center for Molecular Medicine (MDC) and the Universities of Leipzig, Chicago and Sheffield also contributed to this remarkable work. Fluorescent protein reveals development of synaptic vesicles To follow the formation of pre-synapses from the beginning, the researchers used CRISPR gene scissors to insert a fluorescent protein into human stem cells, and generated neurons from the modified stem cells. Thanks to the fluorescent marker, the researchers were now able to observe the development of nascent synaptic vesicles in living developing human nerve cells directly under the microscope. Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to the site of synapse formation. Credit: Barth van Rossum Synaptic vesicles are the membrane vesicles that contain messengers and are stored at each synapse to convert electrical signals into chemical signals. Together with scaffolding proteins that tell synaptic vesicles where the synapse is, and calcium channels that chemically translate the electrical signal, these vesicles form the central elements of the pre-synapse. All three components have their own genes and are therefore made up of different protein molecules. For this reason, it was previously thought that they also take different routes to ultimately come together in one place to form a functional synapse. All components set off together However, the researchers’ observations speak against this hypothesis. “The synaptic vesicle proteins and the proteins of the so-called ‘active zone’ and likely also the adhesion proteins that hold synapses together, share the same bus,” states research group leader Professor Dr. Volker Haucke, describing the surprising finding. “It was highly controversial. And yet our data in human neurons in culture seem quite clear.” But how exactly do the proteins get to the site of synapse formation? In their study, the researchers were able to show, for one thing, that a machinery of motor proteins powers axonal transport. According to their findings, the main driver is a kinesin known as “KIF1A”. This motor protein is best known for its association with neurological disorders in the peripheral nervous system and the brain. “We suspect that mutations in KIF1A interfere with axonal transport of pre-synaptic proteins, resulting in neurological symptoms such as movement disorders, ataxia, or mental disability,” Volker Haucke explains. The scientist is also a professor of molecular pharmacology at Freie Universität Berlin. Moreover, the researchers were also able to determine the cell-biological identity of the axonal carriers. That led to another surprise: While the vast majority of secretory vesicles originate from the so-called Golgi apparatus, the axonal transport vesicles do not contain Golgi markers, but share markers with the endolysosomal system, which typically is involved in the degradation of defective proteins in non-neuronal cells. It was a novel combination of light and high-resolution electron microscopy that allowed the researchers to view the axonal transport vesicles ultrastructurally, enabling them to describe their size and shape. Discovery of transport organelles that exist only in neurons “Our work suggests that neurons have invented a new kind of organelle, a transport organelle that may be unique to neurons,” explained Dr. Sila Rizalar, a postdoctoral fellow at the FMP and lead author of the study published in Science. “This was as little known as the shared transport pathway.” The new findings from basic research could one day be useful for clinical applications. After all, when the contact points between neurons break down, whether due to disease, accident, or the aging process, it is important to understand the mechanism of axonal transport and the key proteins involved in order to intervene therapeutically. “Ideally, it will be possible to restore or enhance axonal transport to promote neuronal regeneration or counteract aging,” remarks Volker Haucke. Although the researchers have now unraveled a key mechanism of synapse formation, many questions remain unanswered, such as how the newly discovered transport organelles are formed, what they are made of, and how they deliver their cargo – synapse molecules – to their destination. It also raises the question of whether, perhaps, lifelong memories are stored using the same axonal transport mechanism that is used to form synapses. These are questions that Volker Haucke and his team are now keen to answer. The prospects are exciting. Reference: “Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly” by Filiz Sila Rizalar, Max T. Lucht, Astrid Petzoldt, Shuhan Kong, Jiachen Sun, James H. Vines, Narasimha Swamy Telugu, Sebastian Diecke, Thomas Kaas, Torsten Bullmann, Christopher Schmied, Delia Löwe, Jason S. King, Wonhwa Cho, Stefan Hallermann, Dmytro Puchkov, Stephan J. Sigrist and Volker Haucke, 12 October 2023, Science. DOI: 10.1126/science.adg1075 RRG455KLJIEVEWWF |
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