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文章數：93 |
 三希樓慶生氣氛夠嗎？》台中公益路美食地圖｜10家餐廳實測心得 |
| 休閒生活｜旅人手札 2026/04/21 09:10:36 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： KoDō 和牛燒肉適合約會嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。加分100%浜中特選昆布鍋物長輩會喜歡嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。加分100%浜中特選昆布鍋物假日會大排長龍嗎？ 下一餐，不妨從這10家開始。茶六燒肉堂網路評價符合期待嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。永心鳳茶需要訂位嗎？ 如果你有私心愛店，也歡迎留言分享，永心鳳茶肉質如何？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。印月餐廳情侶來合適嗎？ New methods have shown that platypus has ten sex chromosomes. Credit: © Doug Gimesy Three papers unveil the extraordinary diversity of animal sex chromosomes. The sex chromosomes genetically define the developmental fate of an embryo to become a male or a female individual, and usually appear as one pair of morphologically different chromosomes between sexes. For example, women have one pair of XX chromosomes, while men have one pair of XY chromosomes. Now three studies led or co-led by Qi Zhou’s group at the University of Vienna and Zhejiang University of China uncovered the unusual sex chromosomes of Australian iconic animals platypus and emu, as well as Pekin duck. Platypus have five pairs of sex chromosomes forming an unusual chain shape, while the sex chromosomes of emu and duck are not as different between sexes as those of humans. These works are the results of international collaboration between scientists from Austria, Australia, China, and Denmark, and are published as research papers together on Jan. 6th in the journals Nature, Genome Research, and GigaScience. Sex chromosomes are presumed to originate from a pair of identical ancestral chromosomes by acquiring a male- or a female-determining gene on one chromosome. To prevent the sex-determining gene from appearing in the opposite sex, recombination is suppressed on sex chromosomes. This leads to the degeneration of the Y chromosome (or the W chromosome in the case of birds) and the morphological difference of sex chromosomes between sexes. For example, the human Y chromosome bears only less than 50 genes, while the human X chromosome still maintains over 1500 genes from the autosomal ancestor. This process occurred independently in birds, in monotremes (the Australian platypus and echidnas), and in the other mammals (therians, e.g., kangaroo, mouse, human, etc.) Platypus Has Ten Sex Chromosomes With its venom, duck-bill, egg, and milk, platypus features an extraordinary combination of reptiles, birds, and mammals. Previous work showed that platypus, although undoubtedly a mammalian species, have sex chromosomes that do not share the same origin with those of humans. It turns out that the male platypus has five pairs of XY chromosomes (named as X1Y1, X2Y2, etc.), and none of them are homologous to the XY of human or mouse. These ten sex chromosomes pair with each other in a head-to-tail manner and form a chain during meiosis when sperm cells develop. The genetic makeup and the evolution process of such a complex and unique sex chromosome system remained unclear, because the previously published platypus genome was from a female, and only a quarter of the sequences was mapped onto chromosomes. Cutting-Edge Sequencing Techniques An international team of researchers adopted a new sequencing technique (called PacBio, or third-generation sequencing) that can “read” the genome information for over 300-fold longer in length than the last-generation technique, and the new chromatin conformation capture technique that can connect and map the genomic sequences into the chromosome level. “With further laborious cytogenetic experiments, we improved the genome quality and mapped over 98% of the sequences into 21 autosomes, and 5X and 5Y chromosomes of platypus,” says Guojie Zhang from BGI-Shenzhen and University of Copenhagen. “The new genomes are a hugely valuable public resource for research in mammalian biology and evolution, with applications in wildlife conservation and even human health,” says Frank Grützner at University of Adelaide in Australia. From a Ring to a Chain “What surprised us is that, from the new sex chromosome sequences, we found the last Y chromosome, Y5 does not share many sequences with its pairing X5 chromosome, but with the first X chromosome of the chain, X1”, says Qi Zhou. “This suggested that the 10 platypus sex chromosomes used to be in a ring shape. Maybe the acquisition of a male-determining gene and suppression of recombination broke the ancestral chromosome ring into a chain.” This part of the sex chromosome work provides an entirely new perspective on the evolution of this extraordinary sex chromosome system, along with other new discoveries of platypus genes related to milk production, loss of teeth and so on, were published in Nature as a research article. Different Sex Systems of Birds and Mammals With similar new techniques used for the platypus genome, the Zhou group simultaneously decoded the sex chromosome sequences of emu and Pekin duck, which represent the different phase of sex chromosome evolution. Most mammalian and bird species’ sex chromosomes have evolved into their terminal stage of evolution like that of human or chicken. A key difference between mammals and birds is that instead of the XY sex system, birds have so-called ZW sex chromosomes. That is, male birds have a pair of ZZ chromosomes, female birds have a Z and a W sex chromosomes. Slow-Evolving Sex Chromosomes of Emu and Duck The Y or W chromosomes usually have lost most functional genes, and become a “gene desert” full of repetitive sequences. Emu is an exception: its sex chromosomes are largely like a pair of autosomes, with over two-thirds of the sequences and active genes still shared between the Z and W chromosomes. “This may be related to the slower evolution rate of the emu compared to other birds”, says Jing Liu, a Ph.D. student in the Zhou group. “By comparing the genomes of emu and 11 other bird species, we found that large-bodied birds like emu and ostrich tend to have much fewer chromosome rearrangements than other birds.” Another possible reason is that these flightless large birds may undergo much weaker sexual selection, a potential driver for sex chromosome evolution, compared to other birds, given that male and female emus are largely monomorphic. This provides a great system to understand how sex chromosomes evolve in their early phase – and in the case of Pekin duck, in the middle phase. Another project from the Zhou group generated the high-quality genome sequence of Pekin duck, a very popular poultry species. Emu, duck, and chicken together mark the different time phases of sex chromosome evolution. In this work, we found that the W chromosomes of emu and duck have retained many more functional genes on their W chromosomes compared to the chicken. Such a large variation in the tempo of sex chromosome evolution is not observed in mammals, and reflects the different evolutionary modes of the XY and ZW sex systems. These novel sex chromosome sequences of emu and duck will also provide important resources for poultry studies. References: “Platypus and echidna genomes reveal mammalian biology and evolution” by Yang Zhou, Linda Shearwin-Whyatt, Jing Li, Zhenzhen Song, Takashi Hayakawa, David Stevens, Jane C. Fenelon, Emma Peel, Yuanyuan Cheng, Filip Pajpach, Natasha Bradley, Hikoyu Suzuki, Masato Nikaido, Joana Damas, Tasman Daish, Tahlia Perry, Zexian Zhu, Yuncong Geng, Arang Rhie, Ying Sims, Jonathan Wood, Bettina Haase, Jacquelyn Mountcastle, Olivier Fedrigo, Qiye Li, Huanming Yang, Jian Wang, Stephen D. Johnston, Adam M. Phillippy, Kerstin Howe, Erich D. Jarvis, Oliver A. Ryder, Henrik Kaessmann, Peter Donnelly, Jonas Korlach, Harris A. Lewin, Jennifer Graves, Katherine Belov, Marilyn B. Renfree, Frank Grutzner, Qi Zhou and Guojie Zhang, 6 January 2021, Nature. DOI: 10.1038/s41586-020-03039-0 “A new emu genome illuminates the evolution of genome configuration and nuclear architecture of avian chromosomes” by Jing Liu, Zongji Wang, Jing Li, Luohao Xu, Jiaqi Liu, Shaohong Feng, Chunxue Guo, Shengchan Chen, Zhanjun Ren, Jinpeng Rao, Kai Wei, Yuezhou Chen, Erich Jarvis, Guojie Zhang and Qi Zhou, 6 January 2021, Genome Research. DOI: 10.1101/gr.271569.120 “A new duck genome reveals conserved and convergently evolved chromosome architectures of birds and mammals” by Jing Li, Jilin Zhang, Jing Liu, Yang Zhou, Cheng Cai, Luohao Xu, Xuelei Dai, Shaohong Feng, Chunxue Guo, Jinpeng Rao, Kai Wei, Erich D Jarvis, Yu Jiang, Zhengkui Zhou, Guojie Zhang and Qi Zhou, 6 January 2021, GigaScience. DOI: 10.1093/gigascience/giaa142 An image of an anole (a species of ‘false chameleon’) crushing a snail with its jaws. Credit: Professor Anthony Herrel University of Bristol researchers reveal key drivers behind diverse jaw shapes in lizards and snakes, focusing on ecological and evolutionary influences. Researchers from the University of Bristol have uncovered new insights into how lizards and snakes—the most diverse group of land vertebrates, with nearly 12,000 species—have evolved a remarkable variety of jaw shapes, driving their extraordinary ecological success. Published in the Proceedings of the Royal Society B, this study offers a new understanding of the intricate factors influencing the evolution of lower jaw morphology in these animals, collectively known as lepidosaurs. Factors Influencing Jaw Shape Evolution in Lepidosaurs The researchers discovered that jaw shape evolution in lepidosaurs is influenced by a complex interplay of factors beyond ecology, including phylogeny (evolutionary relatedness) and allometry (the scaling of shape with size). In terms of jaw shape, the team found that snakes are morphological outliers, exhibiting unique jaw morphologies, likely due to their highly flexible skulls and extreme mechanics that enable them to swallow prey many times larger than their heads. “Interestingly, we found that jaw shape evolves particularly fast in ecologically specialized groups, such as in burrowing and aquatic species, and in herbivorous lizards, suggesting that evolutionary innovation in the lower jaw was key to achieve these unique ecologies,” explained Dr. Antonio Ballell Mayoral based in Bristol’s School of Earth Sciences. “Our study shows how lizards and snakes evolved their disparate jaw shapes which adapted to their wide range of ecologies, diets, and habitats, driving their extraordinary diversity.” Diagram showing rates of evolution of lower jaw shape across the ‘family tree’ of lepidosaurs. Credit: Dr. Antonio Ballell Mayoral and colleagues Role of Morphological Innovation This work underscores the critical role of morphological innovation in promoting the diversification of highly biodiverse groups like lepidosaurs. The lower jaw – a vital component of the vertebrate feeding apparatus – has been a key element in their ecological experimentation and adaptation. Looking ahead, the team plans to delve deeper into the evolution of the lepidosaur head. “Lower jaws are important, but they work together with the jaw closing muscles to support essential functions like feeding and defense,” Dr. Ballell Mayoral added. “We are exploring the relationship between skull shape and the arrangement of the jaw closing musculature through evolution, and how it has impacted the diversification of feeding mechanics and habits.” Reference: “Ecological drivers of jaw morphological evolution in lepidosaurs” by Antonio Ballell, Hugo Dutel, Matteo Fabbri, Elizabeth Martin-Silverstone, Aleksandra Kersley, Chrissy L. Hammond, Anthony Herrel and Emily J. Rayfield, 30 November 2024, Proceedings of the Royal Society B. DOI: 10.1098/rspb.2024.2052 Research by Gustavo Caetano-Anollés and Fayez Aziz, University of Illinois, reveals a “big bang” during the evolution of protein subunits known as domains. The team looked for protein relationships and domain recruitment into proteins over 3.8 billion years across all taxonomic units. Their results could have implications for vaccine development and disease management. Credit: Fred Zwicky, University of Illinois Proteins have been quietly taking over our lives since the COVID-19 pandemic began. We’ve been living at the whim of the virus’s so-called “spike” protein, which has mutated dozens of times to create increasingly deadly variants. But the truth is, we have always been ruled by proteins. At the cellular level, they’re responsible for pretty much everything. Proteins are so fundamental that DNA – the genetic material that makes each of us unique – is essentially just a long sequence of protein blueprints. That’s true for animals, plants, fungi, bacteria, archaea, and even viruses. And just as those groups of organisms evolve and change over time, so too do proteins and their component parts. A new study from University of Illinois researchers, published in the journal Scientific Reports, maps the evolutionary history and interrelationships of protein domains, the subunits of protein molecules, over 3.8 billion years. “Knowing how and why domains combine in proteins during evolution could help scientists understand and engineer the activity of proteins for medicine and bioengineering applications. For example, these insights could guide disease management, such as making better vaccines from the spike protein of COVID-19 viruses,” says Gustavo Caetano-Anollés, professor in the Department of Crop Sciences, affiliate of the Carl R. Woese Institute for Genomic Biology at Illinois, and senior author on the paper. Caetano-Anollés has studied the evolution of COVID mutations since the early stages of the pandemic, but that timeline represents a vanishingly tiny fraction of what he and doctoral student Fayez Aziz took on in their current study. The researchers compiled sequences and structures of millions of protein sequences encoded in hundreds of genomes across all taxonomic groups, including higher organisms and microbes. They focused not on whole proteins, but instead on structural domains. “Most proteins are made of more than one domain. These are compact structural units, or modules, that harbor specialized functions,” Caetano-Anollés says. “More importantly, they are the units of evolution.” After sorting proteins into domains to build evolutionary trees, they set to work building a network to understand how domains have developed and been shared across proteins throughout billions of years of evolution. “We built a time series of networks that describe how domains have accumulated and how proteins have rearranged their domains through evolution. This is the first time such a network of ‘domain organization’ has been studied as an evolutionary chronology,” Fayez Aziz says. “Our survey revealed there is a vast evolving network describing how domains combine with each other in proteins.” Each link of the network represents a moment when a particular domain was recruited into a protein, typically to perform a new function. “This fact alone strongly suggests domain recruitment is a powerful force in nature,” Fayez Aziz says. The chronology also revealed which domains contributed important protein functions. For example, the researchers were able to trace the origins of domains responsible for environmental sensing as well as secondary metabolites, or toxins used in bacterial and plant defenses. The analysis showed domains started to combine early in protein evolution, but there were also periods of explosive network growth. For example, the researchers describe a “big bang” of domain combinations 1.5 billion years ago, coinciding with the rise of multicellular organisms and eukaryotes, organisms with membrane-bound nuclei that include humans. The existence of biological big bangs is not new. Caetano-Anollés’ team previously reported the massive and early origin of metabolism, and they recently found it again when tracking the history of metabolic networks. The historical record of a big bang describing the evolutionary patchwork of proteins provides new tools to understand protein makeup. “This could help identify, for example, why structural variations and genomic recombinations occur often in SARS-CoV-2,” Caetano-Anollés says. He adds that this new way of understanding proteins could help prevent pandemics by dissecting how virus diseases originate. It could also help mitigate disease by improving vaccine design when outbreaks occur. Reference: “Evolution of networks of protein domain organization” by M. Fayez Aziz and Gustavo Caetano-Anollés, 8 June 2021, Scientific Reports. DOI: 10.1038/s41598-021-90498-8 The work was supported by the National Science Foundation and the U.S. Department of Agriculture. The Department of Crop Sciences is in the College of Agricultural, Consumer and Environmental Sciences at the University of Illinois. RRG455KLJIEVEWWF |
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