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 加分100%浜中特選昆布鍋物整體值得推薦嗎？》台中公益路餐廳推薦｜10間必吃美食實測評比 |
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身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 加分100%浜中特選昆布鍋物需要訂位嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。一頭牛日式燒肉家庭過節聚會適合嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。KoDō 和牛燒肉網路評價符合期待嗎？ 下一餐，不妨從這10家開始。NINI 尼尼臺中店口味偏臺式還是日式？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。KoDō 和牛燒肉上餐速度快嗎？ 如果你有私心愛店，也歡迎留言分享，一頭牛日式燒肉服務態度如何？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。KoDō 和牛燒肉尾牙氣氛熱鬧嗎？ A close-up of extended polyps of an apparently healthy great star coral colony (Montastraea cavernosa) on a reef near Fort Lauderdale, Florida. The tentacles surrounding the mouth of each polyp help trap food particles for the coral to eat. The brown coloration is from the symbiotic microalgae (Symbiodiniaceae) that live in the coral tissues. Credit: Valerie Paul The new treatment provides a viable alternative to traditional antibiotic treatment, minimizing the threat of resistant pathogenic bacteria. Scientists from the Smithsonian’s National Museum of Natural History have discovered the first effective bacterial probiotic capable of treating and staving off stony coral tissue loss disease (SCTLD). This enigmatic disease has wreaked havoc on Florida’s coral reefs since 2014 and is swiftly permeating the Caribbean region. The researchers’ findings were published in the journal Communications Biology. It presents a promising alternative to the currently used broad-spectrum antibiotic, amoxicillin. While amoxicillin is the only verified treatment for the disease so far, and it carries the potential risk of fostering antibiotic-resistant bacteria. SCTLD afflicts at least two dozen species of so-called hard corals, which provide essential habitats for innumerable fishes and marine animals of economic and intrinsic value while also helping to defend coastlines from storm damage. Since its discovery in Florida in 2014, cases of SCTLD have been confirmed in at least 20 countries. The precise cause of the malady remains unknown but once a coral is infected, its colony of polyps can die within weeks. The remaining live tissue on this great star coral colony (Montastraea cavernosa) in Florida is being destroyed by stony coral tissue loss disease (SCTLD). The bright white margin surrounding the dark brown, living coral tissue is where the coral is bleaching and dying due to the disease. Credit: Kelly Pitts “It just eats the coral tissue away,” said Valerie Paul, head scientist at the Smithsonian Marine Station at Fort Pierce, Florida, and senior author of the study. “The living tissue sloughs off and what is left behind is just a white calcium carbonate skeleton.” Paul has been studying coral reefs for decades, but she said she decided to go “all in” on SCTLD in 2017 because it was so deadly, so poorly understood, and spreading so fast. Disease-Resistant Corals While probing how the disease is spread, Paul and a team including researchers from the University of Florida discovered that some fragments of great star coral (Montastraea cavernosa) swiftly developed SCTLD’s characteristic lesions and died, but other pieces never got sick at all. Though the precise cause of SCTLD is unknown, the efficacy of antibiotics as a treatment suggested pathogenic bacteria were somehow involved in the progression of the disease. For this reason, the researchers collected samples of the naturally occurring, non-pathogenic bacteria present on a pair of disease-resistant great star coral fragments for further testing. With these samples, the research team aimed to identify what, if any, naturally occurring microorganisms were protecting some great star corals from SCTLD. A close look at a piece of diseased great star coral (Montastraea cavernosa) that is cut and ready for testing and treatment in an aquarium. The white coral skeleton on the left shows where two coral polyps have already died from stony coral tissue loss disease (SCLTD). Credit: Kelly Pitts Probiotic Solution First, the team tested the 222 bacterial strains from the disease-resistant corals for antibacterial properties using three strains of harmful bacteria previously isolated from corals infected with SCTLD. Paul and Blake Ushijima, lead author of the study and an assistant professor at the University of North Carolina Wilmington who was formerly a George Burch Fellow at Smithsonian Marine Station, found 83 strains with some antimicrobial activity, but one in particular, McH1-7, stood out. The team then conducted chemical and genetic analyses to discover the compounds behind McH1-7’s antibiotic properties and the genes behind those compounds’ production. Finally, the researchers tested McH1-7 with live pieces of great star coral. These lab trials provided the final bit of decisive proof: McH1-7 stopped or slowed the progression of the disease in 68.2% of 22 infected coral fragments and even more notably prevented the sickness from spreading in all 12 transmission experiments, something antibiotics are unable to do. Going forward, Paul said there is a need to work on improved delivery mechanisms if this probiotic is going to be used at scale in the field. Currently, the primary method of applying this coral probiotic is to essentially wrap the coral in a plastic bag to create a mini aquarium and then inject the helpful bacteria. Perhaps even more importantly, Paul said it remains to be seen whether the bacterial strain isolated from the great star coral will have the same curative and prophylactic effects for other species of coral. The potential of this newly identified probiotic to help Florida’s embattled corals without the danger of inadvertently spawning antibiotic-resistant bacteria represents some urgently needed good news, Paul said. “Between ocean acidification, coral bleaching, pollution and disease there are a lot of ways to kill coral,” Paul said. “We need to do everything we can to help them so they don’t disappear.” Reference: “Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease” by Blake Ushijima, Sarath P. Gunasekera, Julie L. Meyer, Jessica Tittl, Kelly A. Pitts, Sharon Thompson, Jennifer M. Sneed, Yousong Ding, Manyun Chen, L. Jay Houk, Greta S. Aeby, Claudia C. Häse and Valerie J. Paul, 6 April 2023, Communications Biology. DOI: 10.1038/s42003-023-04590-y This interdisciplinary research is part of the museum’s new Ocean Science Center, which aims to consolidate museum’s marine research expertise and vast collections into a collaborative center to expand understanding of the world’s oceans and enhance their conservation. The study was funded by the Smithsonian, the Florida Department of Environmental Protection, the National Science Foundation, the National Oceanic and Atmospheric Administration and the National Institutes of Health. Researchers have sequenced the complete X and Y chromosomes of several great ape species, revealing significant evolutionary variations, especially in the rapidly evolving Y chromosome. This study, highlighting both stable and dynamic genomic regions, offers new insights into primate and human evolution, as well as the conservation of these endangered species. Credit: SciTechDaily.com Complete X and Y chromosome sequences from six different primate species have been successfully mapped, revealing a rich diversity among these species and providing deeper insights into their evolutionary processes. This extensive genomic mapping highlights the unique and shared characteristics across these species, offering a clearer understanding of their evolutionary trajectories. A team of scientists funded by the National Institutes of Health (NIH) has generated the first complete chromosome sequences from non-human primates. Published today (May 29) in the journal Nature, these sequences uncover remarkable variation between the Y chromosomes of different species, showing rapid evolution, in addition to revealing previously unstudied regions of great ape genomes. Since these primate species are the closest living relatives to humans, the new sequences can provide insights into human evolution. The researchers focused on the X and Y chromosomes, which play roles in sexual development and fertility, among many other biological functions. They sequenced chromosomes from five great ape species, chimpanzee, bonobo, gorilla, and Bornean and Sumatran orangutans, as well as one other primate species that is more distantly related to humans, the siamang gibbon. “These chromosome sequences add a significant amount of new information,” said Brandon Pickett, Ph.D., a postdoctoral fellow at the National Human Genome Research Institute (NHGRI), part of NIH, and an author of the study. “Only the chimpanzee genome sequence was fairly complete before this, but even that still had large gaps, especially in regions of repetitive DNA.” Complete X and Y chromosome sequences from six primate species reveal species diversity and insights into evolution. Credit: Ernesto Del Aguila III, National Human Genome Research Institute Advances in DNA Analysis Analyzing these new sequences, the researchers estimated that 62 to 66% of the X chromosomes and 75 to 82% of the Y chromosomes are composed of repetitive DNA sequences. These sequences are much more challenging for scientists to characterize, and studying repetitive DNA has only become possible in recent years due to new DNA sequencing technologies and analysis methods. The researchers compared the sequences of the ape chromosomes to the human X and Y chromosomes to understand their evolutionary histories. Like the human X and Y, the great ape Y chromosomes have far fewer genes compared to the X chromosomes. The researchers also used a computational method called alignment, which indicates regions of the chromosome that have stayed relatively the same over the course of evolution, revealing the effects of different evolutionary pressures on different parts of the genome. The researchers found that over 90% of the ape X chromosome sequences aligned to the human X chromosome, showing that the X chromosomes have remained relatively unchanged over millions of years of evolution. However, only 14% to 27% of the ape Y chromosome sequences aligned to the human Y chromosome. Surprising Variations in Y Chromosomes “The extent of the differences between the Y chromosomes of these species was very surprising,” said Kateryna Makova, Ph.D., a professor at Pennsylvania State University and leader of the study. “Some of these species diverged from the human lineage only seven million years ago, which is not a lot of time in terms of evolution. This shows that the Y chromosomes are evolving very fast.” A notable difference among the primate Y chromosomes is their length. For example, the Y chromosome from the Sumatran orangutan is twice as long as the gibbon’s Y chromosome. Variation in the number and types of DNA repeats accounts for some of the differences in chromosome lengths. One type of repeat is called a palindrome, a DNA sequence which contains inverted DNA repeats. DNA palindromes are similar to language palindromes such as “racecar” or “kayak,” in which the letters in the first half of the word repeat in reverse in the second half of the word, so the sequence of the letters is the same forwards and backwards. However, the DNA palindromes can be over one hundred thousand letters long. Unique Gene Variations and Future Research The researchers found that the DNA palindromes on the primate X and Y chromosomes almost always contain genes, which repeat in many copies along the length of the chromosome. Most genes in primate genomes have only two copies, one on each chromosome in a pair. Researchers suspect that having many copies in these palindromes helps to protect genes, especially on the Y chromosome. Since there is typically only one Y chromosome per cell, if a gene on the Y chromosome is damaged, there is not another chromosome with a copy of the gene that can be used as a template to repair the damage. “Having these genes in palindromes is like keeping a backup copy,” said Adam Phillippy, Ph.D., a senior investigator at NHGRI and senior author of the study. “We know that many of these genes are performing important functions, and so we expected to see the same genes in palindromes across different species, but this doesn’t seem to be the case.” The researchers studied several groups of genes contained within the palindromes, many of which play roles in sperm production and are thus important for fertility. While palindromes were found on all the primate Y chromosomes studied, the specific palindrome sequences and the genes contained in these palindromes were often distinct for each species. “There may be even more variation we’re not yet seeing,” said Dr. Phillippy. “On the human Y chromosome, some genes can vary in number between individuals. For each of these other primate species, we’re only looking at a single individual. We don’t know what the rest of the population looks like yet and what other variations we might find.” “However, we have some insights from prior work by our group that suggests extensive variation in the number of copies of Y chromosome genes in humans and other apes,” Dr. Makova added. These great ape chromosome sequences also resolve the sequences of another type of repeat called a DNA satellite, which is a large stretch of repeating sequence. Among the great ape chromosomes, the researchers identified several previously unknown, species-specific satellite sequences. These sequences provide important insights into great ape genomes, as DNA satellites are present across the genome. Specifically, they are concentrated near the ends of chromosomes, called telomeres, and in another region called a centromere, which helps the chromosomes organize during cell division. The centromere sequences of these species were completely unknown before this study and another recent research effort conducted by many of the same researchers. “Having these satellite sequences from great apes open up new territory to explore,” said Dr. Makova, “and similar to our other findings about the Y chromosome, we can see that the centromere of the Y chromosome is highly dynamic.” Implications for Conservation and Understanding Evolution These chromosome sequences can help researchers study the evolution of great apes, including humans. The researchers are currently working to describe the entire genomes of these great ape species, but even alone, the X and Y chromosome sequences offer many insights, especially about the evolutionary forces on the Y chromosome that contribute to its rapid evolution. One factor is that there is typically only one Y chromosome per cell, which leads to accumulating changes to the DNA sequence. Another evolutionary force, Dr. Makova said, is a phenomenon known as male mutation bias. Compared to egg production, sperm production involves more DNA replication. With each replication, there is a chance that the DNA sequence changes. This affects all chromosomes but is particularly impactful for the Y chromosome. Another potential factor is having a small population size, which can influence evolutionary rates. Not only do these ape species have limited populations in the wild, but the Y chromosomes are only present in half the population, further limiting the effective population size of this particular part of the genome. “It’s important to remember that these great ape species are all endangered,” said Dr. Makova. “Not only can we learn about human evolution from these sequences, but we can apply what we know about their genomes and human genomes to better understand the biology and reproduction of these endangered species.” Reference: “The complete sequence and comparative analysis of ape sex chromosomes” by Kateryna D. Makova, Brandon D. Pickett, Robert S. Harris, Gabrielle A. Hartley, Monika Cechova, Karol Pal, Sergey Nurk, DongAhn Yoo, Qiuhui Li, Prajna Hebbar, Barbara C. McGrath, Francesca Antonacci, Margaux Aubel, Arjun Biddanda, Matthew Borchers, Erich Bornberg-Bauer, Gerard G. Bouffard, Shelise Y. Brooks, Lucia Carbone, Laura Carrel, Andrew Carroll, Pi-Chuan Chang, Chen-Shan Chin, Daniel E. Cook, Sarah J. C. Craig, Luciana de Gennaro, Mark Diekhans, Amalia Dutra, Gage H. Garcia, Patrick G. S. Grady, Richard E. Green, Diana Haddad, Pille Hallast, William T. Harvey, Glenn Hickey, David A. Hillis, Savannah J. Hoyt, Hyeonsoo Jeong, Kaivan Kamali, Sergei L. Kosakovsky Pond, Troy M. LaPolice, Charles Lee, Alexandra P. Lewis, Yong-Hwee E. Loh, Patrick Masterson, Kelly M. McGarvey, Rajiv C. McCoy, Paul Medvedev, Karen H. Miga, Katherine M. Munson, Evgenia Pak, Benedict Paten, Brendan J. Pinto, Tamara Potapova, Arang Rhie, Joana L. Rocha, Fedor Ryabov, Oliver A. Ryder, Samuel Sacco, Kishwar Shafin, Valery A. Shepelev, Viviane Slon, Steven J. Solar, Jessica M. Storer, Peter H. Sudmant, Sweetalana, Alex Sweeten, Michael G. Tassia, Françoise Thibaud-Nissen, Mario Ventura, Melissa A. Wilson, Alice C. Young, Huiqing Zeng, Xinru Zhang, Zachary A. Szpiech, Christian D. Huber, Jennifer L. Gerton, Soojin V. Yi, Michael C. Schatz, Ivan A. Alexandrov, Sergey Koren, Rachel J. O’Neill, Evan E. Eichler and Adam M. Phillippy, 29 May 2024, Nature. DOI: 10.1038/s41586-024-07473-2 Artwork representing calcium signalling in a rosette colony of the choanoflagellate S. rosetta. Credit: Davis Laundon, Ella Maru Studio and Kate Zvorykina (Ella Maru Studio, Inc.) Scientists discovered that choanoflagellates coordinate their movements through electrical signaling via voltage-gated calcium channels, offering key insights into the early evolution of multicellularity and nervous systems. A recent study published in Science Advances provides compelling evidence of electrical signaling and coordinated behavior in choanoflagellates, the closest living relatives of animals. This discovery sheds light on the early evolution of multicellular communication and the origins of animal nervous systems. Researchers from the Burkhardt group at the Michael Sars Centre, University of Bergen, uncovered a remarkable diversity of behaviors within the rosette-shaped colonies of the choanoflagellate Salpingoeca rosetta – and the small organisms held even more surprises. “We found communication among the cells of the colonies, which regulates shape and ciliary beating across the rosette,” explains first author Jeffrey Colgren. “We didn’t have clear expectations of what we would see in the cultures before putting them under the microscope, but when we did, it was very exciting.” Multicellularity and Early Animal Evolution Multicellularity is a defining characteristic of all animals, enabling them to interact with their environment in unique ways by integrating the input of highly specialized cell types, such as neurons and muscle cells. For choanoflagellates, flagellated organisms found in marine and aquatic environments all over the globe, the boundary between uni- and multicellularity is less distinct. A rosette-shaped colony of S. rosetta, a microscopic marine organism that is part of the sister group to all animals. Credit: Jeffrey Colgren Some species, including S.rosetta, exhibit complex life cycles that include colonial stages. While the colonies are formed through cell divisions, much like the developing embryos of animals, they lack specialized cell types and are more akin to a group of individual cells than a cohesive organism. “S. rosetta is a powerful model for investigating the emergence of multicellularity during animal evolution,” says last author Pawel Burkhardt. “Since our study reveals that colonial choanoflagellates coordinate their movements through shared signaling pathways, it offers fascinating insights into early sensory-motor systems.” Discovery of Voltage-Gated Calcium Channels Using a newly developed genetic tool that enables visualization of calcium activity in S. rosetta, the team found that the cells synchronize their behavior through voltage-gated calcium channels, the same type of channels used by animal neurons and muscle cells. “This evidence of how information flows between cells in choanoflagellate colonies demonstrates cell-cell signaling at the cusp of multicellularity,” says Colgren. Strikingly, the discovery suggests that the ability to coordinate movement at the cellular level predates the first animals. Moving forward, the team plans to further investigate how signals propagate between cells and whether similar mechanisms exist in other choanoflagellate species. “The tools developed and findings from this study open up a lot of new and interesting questions.” Colgren concludes. “We’re really excited to see where ourselves and others take this in the future.” Reference: “Electrical signaling and coordinated behavior in the closest relative of animals” by Jeffrey Colgren and Pawel Burkhardt, 8 January 2025, Science Advances. DOI: 10.1126/sciadv.adr7434 RRG455KLJIEVEWWF |
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