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文章數：89 |
 NINI 尼尼台中店團體宴客合適嗎？》台中公益路聚餐推薦｜10大類型餐廳評比 |
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身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： NINI 尼尼臺中店假日會大排長龍嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。一頭牛日式燒肉情侶來合適嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。三希樓有什麼推薦搭配？ 下一餐，不妨從這10家開始。加分100%浜中特選昆布鍋物尾牙預算好掌控嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。一頭牛日式燒肉值得排隊嗎？ 如果你有私心愛店，也歡迎留言分享，TANG Zhan 湯棧有提供尾牙方案嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。茶六燒肉堂第一次來要點什麼？ Left: The organ of Corti from a normal (control) mouse. The hair cells and their support cells are lined up in an alternating, checkerboard-like pattern. Right: The organ of Corti from a nectin KO mouse. The top row of images were taken at 12 days old, the bottom row at 28 days old. 2 weeks after birth, the hair cells in nectin KO mice disappeared due to apoptosis (cell death). The white arrows indicate where hair cells became attached to each other. Credit: Katsunuma S, Togashi H, Kuno S, Fujita T and Nibu K-I (2022) Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea. Front. Cell Dev. Biol. 10:1073830 Japanese researchers have uncovered the critical role of the checkerboard-like arrangement of hair and support cells in the organ of Corti in enabling hearing. A Japanese research group has become the first to reveal that the checkerboard-like arrangement of cells in the inner ear’s organ of Corti is vital for hearing. The discovery gives a new insight into how hearing works from the perspective of cell self-organization and will also enable various hearing loss disorders to be better understood. The research group included Assistant Professor Hideru Togashi of Kobe University’s Graduate School of Medicine and Dr. Sayaka Katsunuma of Hyogo Prefectural Kobe Children’s Hospital. These research results were published online in Frontiers in Cell and Developmental Biology on December 8, 2022. Main Points In the organ of Corti in the inner ear, there are two types of cells arranged in a checkerboard-like mosaic pattern; hair cells responsible for hearing and their support cells. However, the relationship between this checkerboard pattern and hearing function has long remained unclear. In mice in which the cells in the organ of Corti could not form into this checkerboard pattern, only the hair cells died (apoptosis), which resulted in deafness. For the first time in the world, it was understood that the checkerboard layout plays a fundamental structural role in preserving hair cells and their functionality as the arrangement prevents hair cells from adhering to each other. This mosaic pattern of cells has been observed in various sensory organs in many different kinds of animals. Understanding the mechanism behind how cell self-organization forms these mosaic patterns will help illuminate the functions of a variety of sensory organs and the mechanisms behind disorders. Research Background The inner ear cochlea is necessary for hearing sound, and located inside it is the organ of Corti (*1). When the organ of Corti is viewed from above under a microscope, two types of cells arranged in a precisely ordered layout resembling a chess or checkerboard can be seen. Hair cells that convey sound waves to the brain are separated by support cells, which prevent the hair cells from touching each other. Although it has been thought that this checkerboard arrangement is necessary for the organ of Corti to function properly, the relationship between this pattern and hearing function has long remained unclear. This research group previously revealed that this inner ear checkerboard is formed by a cellular segregation mechanism that enables the hair cells and support cells to move into line correctly. Hair cells and support cells each express a different type of the cell adhesion molecule nectin. This results in a hair cell and a support cell adhering more strongly to each other than two hair cells or two support cells would. This property is what causes hair cells and support cells to be arranged in a checkerboard pattern. In a mouse model where one of these nectin molecules is not functional, the properties change and the checkerboard pattern cannot form correctly. In this study, the researchers used these mice to investigate the connection between the checkerboard arrangement of cells and hearing functionality. Research Methodology The research group compared regular (control) mice to mice with one type of nectin not functioning correctly (nectin-3 KO mouse, referred to as nectin KO mouse below). No difference between the mice was observed in the number of hair cells and support cells in the organ of Corti immediately after birth. However, there was a difference in how easily the two types of cell adhere to each other; in the nectin-3 KO mice hair cells adhere together (which does not normally happen) resulting in abnormalities in the checkerboard pattern. At this point, the researchers hypothesized that testing the hearing of these mice might reveal the relationship between hearing and the checkerboard pattern. They measured the hearing of over one-month-old nectin KO mice using the auditory brainstem response (ABR) method (*2). This test revealed that the nectin KO mice were moderately deaf, demonstrating that this hearing loss was caused by the abnormalities in the inner ear. The researchers then examined the organs of Corti of the nectin KO mice that underwent the ABR test and found that the number of hair cells had decreased by approximately half. Next they set out to find out why only the hair cells (and not the support cells) had disappeared. They discovered that after 2 weeks of age, hair cell apoptosis (*3) occurred. In addition, examination of the traces of apoptosis revealed that cell death occurred in many cells that had adhered to each other. This led the researchers to suppose that the hair cells adhering to each other (which does not normally happen) caused the apoptosis. In the epithelial tissue, which also includes the organ of Corti, there are tight junctions between each cell. These tight junctions not only connect the cells, they also prevent various molecules (including ions) from passing between the cells. If the organ of Corti doesn’t have these tight junctions, hair cells cannot function properly, cells die and hearing loss occurs. In nectin KO mice, tight junctions were not formed properly in the places where hair cells adhered together. However, tight junctions did correctly form in between hair cells and support cells. As long as two hair cells were not adhered together, normal cell function remained. In other words, hair cell apoptosis was induced only in the places where hair cells were abnormally adhered to each other and tight junctions did not form correctly. These results revealed for the first time that the checkerboard pattern of hair cells and support cells found in the organ of Corti functions as a fundamental structure, which protects hair cells and their functionality, by preventing hair cells from becoming attached to each other. Further Research Nectin is the causal gene for Margarita Island ectodermal dysplasia (*4). In addition to a cleft lip or palate and intellectual disabilities, deafness has also been reported in some cases of this genetic disorder. Therefore, the results of the current study might provide a new explanation for some cases of deafness where the cause is unclear. This study focused on hearing and demonstrated the physiological significance of the checkerboard-like mosaic pattern of cells in the organ of Corti. However other sensory cells that respond to outside stimuli and their respective supporter cells are also arranged in the same kind of alternating mosaic pattern. These mosaic patterns are found in sensory organs, such as the olfactory epithelium that is responsible for the sense of smell and the retina which is responsible for vision. The fact that these mosaic patterns are not only found in mammals but also in a variety of other organisms suggests that they are functionally important. The mosaic patterns in sensory tissues are created by self-organization due to the differences in adhesiveness between cells. Therefore, focusing research on cellular self-organization in sensory organs will increase our knowledge of the functions of sensory organs and advance our understanding of various related diseases. Glossary Organ of Corti: The sensory organ responsible for hearing. It is located inside the cochlea in the inner ear. Auditory brainstem response (ABR): A method of recording the brain waves that are generated when sound is heard. ABR is not only used to test the hearing of newborn human babies, it can also be used on mice and other animals. Apoptosis: A form of programmed cell death or cellular suicide that occurs in multicellular organisms. Margarita Island ectodermal dysplasia: A genetic disorder caused by mutations in the nectin-1 gene. The main manifestation is a cleft lip or palate accompanied by intellectual disability. Reference “Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea” by Sayaka Katsunuma, Hideru Togashi, Shuhei Kuno, Takeshi Fujita and Ken-Ichi Nibu, 8 December 2022, Frontiers in Cell and Developmental Biology. DOI: 10.3389/fcell.2022.1073830 Acknowledgments This research received funding from the following organizations: KAKENHI grants from the Japan Society for the Promotion of Science (JSPS) (grant numbers: 18H04764, 18K09319, 19H04965, 22K19331), the Japan Science and Technology Agency’s Presto program (JPMJPR1946) and the Takeda Science Foundation. New research reveals that human neocortex neurons communicate more efficiently in one direction, unlike mice’s looping interactions. This finding may enhance artificial neural network development by mimicking human brain connectivity. Experimental setup for multi-patch experiments that record the activity of up to ten neurons. Credit: Charité | Yangfan Peng New research decodes wiring of the human neocortex. New research led by Charité – Universitätsmedizin Berlin and published in Science reveals that the wiring of nerve cells in the human neocortex differs significantly from that in mice. The study discovered that human neurons predominantly transmit signals in a unidirectional manner, whereas mouse neurons typically send signals in looping patterns. This structural difference may enhance the human brain’s ability to process information more efficiently and effectively. The findings hold potential implications for advancing artificial neural network technologies. The neocortex, a critical structure for human intelligence, is less than five millimeters thick. There, in the outermost layer of the brain, 20 billion neurons process countless sensory perceptions, plan actions, and form the basis of our consciousness. How do these neurons process all this complex information? That largely depends on how they are “wired” to each other. More complex neocortex – different information processing “Our previous understanding of neural architecture in the neocortex is based primarily on findings from animal models such as mice,” explains Prof. Jörg Geiger, Director of the Institute for Neurophysiology at Charité. In those models, the neighboring neurons frequently communicate with each other as if they are in dialogue. One neuron signals another, and then that one sends a signal back. That means the information often flows in recurrent loops.” Multi-patch device with robot manipulators that automatically rinse the glass pipettes between two rounds of experiments. Credit: Charité | Yangfan Peng The human neocortex is much thicker and more complex than that of a mouse. Nonetheless, researchers had previously assumed – in part due to lack of data – that it follows the same basic principles of connectivity. A team of Charité researchers led by Geiger has now used exceptionally rare tissue samples and state-of-the-art technology to demonstrate that this is not the case. A clever method of listening in on neuronal communication For the study, the researchers examined brain tissue from 23 people who had undergone neurosurgery at Charité to treat drug-resistant epilepsy. During surgery, it was medically necessary to remove brain tissue in order to gain access to the diseased structures beneath it. The patients had consented to the use of this access tissue for research purposes. Rotating reconstruction of neurons. Credit: Charité | Sabine Grosser To be able to observe the flows of signals between neighboring neurons in the outermost layer of the human neocortex, the team developed an improved version of what is known as the “multipatch” technique. This allowed the researchers to listen in on the communications taking place between as many as ten neurons at once. As a result, they were able to take the necessary number of measurements to map the network in the short time before the cells ceased their activity outside the body. In all, they analyzed the communication channels among nearly 1,170 neurons with about 7,200 possible connections. Feed-forward instead of in cycles They found that only a small fraction of the neurons engaged in reciprocal dialogue with each other. “In humans, the information tends to flow in one direction instead. It seldom returns to the starting point either directly or via cycles,” explains Dr. Yangfan Peng, first author of the publication. He worked on the study at the Institute for Neurophysiology and is now based at the Department of Neurology and the Neuroscience Research Center at Charité. The team used a computer simulation that they devised according to the same principles underlying the human network architecture to demonstrate that this forward-directed signal flow has benefits in terms of processing data. A micropipette from the multipatch device approaches an individual neuron. Credit: Charité | Franz Mittermaier The researchers gave the artificial neural network a typical machine learning task: recognizing the correct numbers from audio recordings of spoken digits. The network model that mimicked the human structures achieved more correct responses to this speech recognition task than the one modeled on mice. It was also more efficient, with the same performance requiring the equivalent of 380 neurons in the mouse model, but only 150 in the human one. An economic role model for AI? “The directed network architecture we see in humans is more powerful and conserves resources because more independent neurons can handle different tasks simultaneously,” Peng explains. “This means that the local network can store more information. It isn’t clear yet whether our findings within the outermost layer of the temporal cortex extend to other cortical regions, or how well they might explain the unique cognitive abilities of humans.” In the past, AI developers have looked to biological models for inspiration in designing artificial neural networks, but have also optimized their algorithms independently of the biological models. “Many artificial neural networks already use some form of this forward-directed connectivity because it delivers better results for some tasks,” Geiger says. “It’s fascinating to see that the human brain also shows similar network principles. These insights into cost-efficient information processing in the human neocortex could provide further inspiration for refining AI networks.” Reference: “Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit” by Yangfan Peng, Antje Bjelde, Pau Vilimelis Aceituno, Franz X. Mittermaier, Henrike Planert, Sabine Grosser, Julia Onken, Katharina Faust, Thilo Kalbhenn, Matthias Simon, Helena Radbruch, Pawel Fidzinski, Dietmar Schmitz, Henrik Alle, Martin Holtkamp, Imre Vida, Benjamin F. Grewe and Jörg R. P. Geiger, 18 April 2024, Science. DOI: 10.1126/science.adg8828 Modifying mosquito gut genes to transmit antimalarial genes to their next generation holds promise as a strategy to combat malaria. Genetically modifying mosquitoes to express antimalarial genes and pass them on to their offspring is being tested as a new strategy to eliminate malaria. Altering a mosquito’s gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published today (April 13, 2021) in eLife. The study is the latest in a series of steps toward using CRISPR-Cas9 gene-editing technology to make changes in mosquito genes that could reduce their ability to spread malaria. If further studies support this approach, it could provide a new way to reduce illnesses and deaths caused by malaria. Growing mosquito resistance to pesticides, as well as malaria parasite resistance to antimalarial drugs, has created an urgent need for new ways to fight the disease. Gene drives are being tested as a new approach. They work by creating genetically modified mosquitoes that, when released into the environment, would spread genes that either reduce mosquito populations or make the insects less likely to spread the malaria parasite. But scientists must prove that this approach is safe and effective before releasing genetically modified mosquitoes into the wild. “Gene drives are promising tools for malaria control,” says first author Astrid Hoermann, Research Associate at Imperial College London, UK. “But we wanted a clear pathway for safely testing such tools in countries where the disease most commonly occurs.” In the study, Hoermann and colleagues genetically modified the malaria-transmitting mosquito Anopheles gambiae. They used the CRISPR-Cas9 technology to insert a gene that encodes an antimalarial protein amidst genes that are turned on after the mosquito eats a blood meal. The team did this in a manner that allowed the whole section of DNA to also function as a gene drive that could be passed on to most of the mosquitoes’ offspring. They initially inserted the gene along with a fluorescent marker to help them track it in three different spots in the DNA, and then later removed the marker, leaving only a minor genetic modification behind. Next, the team bred the mosquitoes to see if they were able to successfully reproduce and remain healthy. They also tested how well the malaria parasite developed in the mosquitoes’ guts. Their experiments provide preliminary evidence that this approach to genetic modifications could create successful gene drives. “These genetic modifications are passive, and could be tested in the field and undergo a stringent regulatory process to ensure they are safe and effective in blocking the parasite without raising concerns of accidental spread in the environment,” explains senior author Nikolai Windbichler, Senior Lecturer at the Department of Life Sciences, Imperial College London. “However, once we combine them with other mosquitoes with an active gene drive, they turn into gene drives themselves without the need for any further changes. Our approach thus brings gene drives one step closer to being tested in the field as a malaria elimination strategy.” Reference: “Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement” by Astrid Hoermann, Sofia Tapanelli, Paolo Capriotti, Giuseppe Del Corsano, Ellen KG Masters, Tibebu Habtewold, George K Christophides and Nikolai Windbichler, 13 April 2021, eLife. DOI: 10.7554/eLife.58791 Funding: Bill and Melinda Gates Foundation RRG455KLJIEVEWWF |
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