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文章數：101 |
 印月餐廳價位會不會太高？》台中公益路美食Top10｜各類餐廳完整比較 |
| 心情隨筆｜心情日記 2026/04/20 09:53:00 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 茶六燒肉堂口味偏臺式還是日式？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。加分100%浜中特選昆布鍋物家庭過節聚會適合嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。三希樓包廂適合尾牙嗎？ 下一餐，不妨從這10家開始。永心鳳茶適合請客嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。茶六燒肉堂年節期間價格會變嗎？ 如果你有私心愛店，也歡迎留言分享，三希樓會太油嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。永心鳳茶小資族值得嗎？ Market squid, Doryteuthis opalescens Credit: © 2001 MBARI Acoustic tools reveal hotspots of ocean life in scattered places. Ocean predators cannot survive on average concentrations of food found in the water. Instead, they survive by exploiting small patches of food-rich areas peppered throughout the world’s waterways. During the 181st Meeting of the Acoustical Society of America, which will be held November 29-December 3, Kelly Benoit-Bird, from the Monterey Bay Aquarium Research Institute, will discuss how sonar or active acoustics can be used to interpret and indicate biological hotspots of ocean life. The talk, “A Sound Resolution to the Food Paradox in the Sea,” will take place Wednesday, December 1, at 4:05 p.m. Eastern U.S. at the Hyatt Regency Seattle. Using active acoustics, where a sound pulse is created and resulting echoes are interpreted, the researchers found the ocean is widely populated with narrow hotspots of activity. Traditionally, these hotspots are missed with conventional sampling tools, but locating them can provide dynamic layered maps of ocean life. “We’re using systems much like those used to find the depth of the ocean, but instead of interpreting echoes from the seafloor, we’re using more sensitive systems that allow us to map layers of life in the water,” said Benoit-Bird. “What we’ve found is that animals of all different sizes, from millimeter-long plankton to large predators, are unevenly distributed, and this variation is really important to how life in the ocean functions.” The findings signify ocean food and biota as patchy, varying with depth and location, suggesting animals must find and exploit small-scale aggregations of resources. The Lasker food paradox proposed in the 1970s found laboratory animals fed the average concentration of ocean food did not survive, but ocean-dwelling animals in the wild did. The paradox is reconciled by Benoit-Bird’s findings, demonstrating animals do not survive on average food concentrations but are well-adapted to locating and capitalizing on patches of resources, and reducing their total energy expenditure to hunt. “For example, if a bucket’s worth of popcorn was spread out evenly throughout the volume of a room, and you had to fly around to capture each kernel, you would spend a lot of energy searching and it would be hard to get enough to be full,” Benoit-Bird said. “If instead, the popcorn was all grouped together, the popcorn would be a much more satisfying snack. The amount of popcorn is the same but changing how it is grouped determines whether you end up with a full belly. “Acoustic tools provide the high spatial resolution and long duration sampling to explore the processes that drive organismal interactions in the ocean. We must understand not only how many animals are in the ocean, but how they are distributed, if we are to effectively manage our living marine resources.” Meeting: 181st Meeting of the Acoustical Society of America Computer simulation of filaments assembling into a division ring in the middle of the cell. Credit: Nicola de Mitri New research reveals how bacterial proteins self-organize by destruction, aiding synthetic material design. How does matter, lifeless by definition, self-organize and make us alive? One of the hallmarks of life, self-organization, is the spontaneous formation and breakdown of biological active matter. However, while molecules constantly fall in and out of life, one may ask how they ‘know’ where, when, and how to assemble, and when to stop and fall apart. A team of researchers led by Professor Anđela Šarić and PhD student Christian Vanhille Campos at the Institute of Science and Technology Austria (ISTA) have addressed these questions in the context of bacterial cell division. Computational simulation of FtsZ treadmilling shows the death of misaligned filaments. Credit: © Christian Vanhille Campos, Šarić lab, ISTA Unveiling New Mechanisms of Protein Assembly The researchers developed a computational model for the assembly of a protein called FtsZ, an example of active matter. During cell division, FtsZ self-assembles into a ring structure at the center of the dividing bacterial cell. This FtsZ ring–called the bacterial division ring–was shown to help form a new ‘wall’ that separates the daughter cells. However, essential physical aspects of FtsZ self-assembly remain unknown. Computational simulation and atomic force microscopy (AFM) experiment on in vitro assemblies. Credit: © Christian Vanhille Campos, Šarić lab, including an AFM video by Philipp Radler, Loose lab, ISTA In a new study, recently published in Nature Physics, computational modelers from the Šarić group team up with experimentalists from Séamus Holden’s group at The University of Warwick, UK, and Martin Loose’s group at ISTA to reveal an unexpected self-assembly mechanism. Their computational work demonstrates how misaligned FtsZ filaments react when they hit an obstacle. By ‘dying’ and re-assembling, they favor the formation of the bacterial division ring, a well-aligned filamentous structure. These findings could have applications in the development of synthetic self-healing materials. Simulating FtsZ filament self-organization by treadmilling. Modeling the treadmilling of FtsZ filaments in a bacterial cell shows how the bacterial division ring forms. Credit: Claudia Flandoli The Role of Treadmilling in Cellular Structures FtsZ forms protein filaments that self-assemble by growing and shrinking in a continuous turnover. This process, called ‘treadmilling,’ is the constant addition and removal of subunits at opposite filament ends. Several proteins have been shown to treadmill in multiple life forms – such as bacteria, animals, or plants. Scientists have previously thought of treadmilling as a form of self-propulsion and modeled it as filaments that move forward. However, such models fail to capture the constant turnover of subunits and overestimate the forces generated by the filaments’ assembly. Computational simulation and live cell imaging in the bacterium Bacillus subtilis. Credit: © Christian Vanhille Campos, Šarić lab, ISTA, including live cell images by Kevin D. Whitley, Holden lab Thus, Šarić and her team set out to model how FtsZ subunits interact and spontaneously form filaments by treadmilling. “Everything in our cells is in a constant turnover. Thus, we need to start thinking of biological active matter from the prism of molecular turnover and in a way that adapts to the outside environment,” says Šarić. What they found was striking. In contrast to self-propelled assemblies that push the surrounding molecules and create a ‘bump’ felt at long molecular distances, they saw that misaligned FtsZ filaments started ‘dying’ when they hit an obstacle. “Active matter made up of mortal filaments does not take misalignment lightly. When a filament grows and collides with obstacles, it dissolves and dies,” says first author Vanhille Campos. Šarić adds, “Our model demonstrates that treadmilling assemblies lead to local healing of the active material. When misaligned filaments die, they contribute to a better overall assembly.” By incorporating the cell geometry and filament curvature into their model, they showed how the death of misaligned FtsZ filaments helped form the bacterial division ring. Proteins (blue) add onto a filament after binding an energy source (black) inside a cell. Credit: Nicola de Mitri Collaborative Breakthroughs in Experimental Validation Driven by the physical theories of molecular interactions, Šarić and her team soon made two independent encounters with experimental groups that helped confirm their results. At a diverse and multidisciplinary conference called ‘Physics Meets Biology,’ they met Séamus Holden, who worked on imaging bacterial ring formation in live cells. At this meeting, Holden presented exciting experimental data showing that the death and birth of FtsZ filaments were essential for the formation of the division ring. This suggested that treadmilling had a crucial role in this process. “Satisfyingly, we found that FtsZ rings in our simulations behaved in the same way as the Bacillus subtilis division rings that Holden’s team imaged,” says Vanhille Campos. Computer simulation of a division ring assembling by dissolution of misaligned model filaments. Credit: Nicola de Mitri In a similar strike of luck, relocating from University College London to ISTA allowed Šarić and her group to team up with Martin Loose, who had been working on assembling FtsZ filaments in a controlled experimental setup in vitro. They saw that the in vitro results closely matched the simulations and further confirmed the team’s computational results. Underlining the cooperation spirit and synergy between the three groups, Šarić says, “We are all stepping outside our usual research fields and going beyond what we normally do. We openly discuss and share data, views, and knowledge, which allows us to answer questions we cannot tackle separately.” Implications for Synthetic Self-Healing Materials Energy-driven self-organization of matter is a fundamental process in physics. The team led by Šarić now suggests that FtsZ filaments are a different type of active matter that invests energy in turnover rather than motility. “In my group, we ask how to create living matter from non-living material that looks living. Thus, our present work could facilitate the creation of synthetic self-healing materials or synthetic cells,” says Šarić. As a next step, Šarić and her team seek to model how the bacterial division ring helps build a wall that will divide the cell into two. Holden and Šarić will continue to investigate this question with the help of a recent 3.7 million Euro grant awarded by the Wellcome Trust. Reference: “Self-organization of mortal filaments and its role in bacterial division ring formation” by Christian Vanhille-Campos, Kevin D. Whitley, Philipp Radler, Martin Loose, Séamus Holden and Anđela Šarić, 12 August 2024, Nature Physics. DOI: 10.1038/s41567-024-02597-8 The new multi-organ chip has the size of a glass microscope slide and allows the culture of up to four human-engineered tissues, whose location and number can be tailored to the question being asked. These tissues are connected by vascular flow, but the presence of a selectively permeable endothelial barrier maintains their tissue-specific niche. Credit: Kacey Ronaldson-Bouchard/Columbia Engineering Major advance from Columbia Engineering team demonstrates the first multi-organ chip made of engineered human tissues linked by vascular flow for improved modeling of systemic diseases like cancer. Engineered tissues have become an essential component for modeling diseases and testing the efficacy and safety of drugs in a human context. A key hurdle for researchers has been figuring out how to model body functions and systemic diseases with multiple engineered tissues that can physiologically communicate — just like they do in the body. However, it is essential to provide each engineered tissue with its own environment so that the specific tissue phenotypes can be maintained for weeks to months, as required for biological and biomedical studies. Making the challenge even more complex is the necessity of linking the tissue modules together to facilitate their physiological communication, which is required for modeling conditions that involve more than one organ system, without sacrificing the individual engineered tissue environments. Novel Plug-and-Play Multi-Organ Chip, Customized to the Patient Up to now, no one has been able to meet both conditions. Today, a team of researchers from Columbia Engineering and Columbia University Irving Medical Center reports that they have developed a model of human physiology in the form of a multi-organ chip consisting of engineered human heart, bone, liver, and skin that are linked by vascular flow with circulating immune cells, to allow recapitulation of interdependent organ functions. The researchers have essentially created a plug-and-play multi-organ chip, which is the size of a microscope slide, that can be customized to the patient. Because disease progression and responses to treatment vary greatly from one person to another, such a chip will eventually enable personalized optimization of therapy for each patient. The study is the cover story of the April 2022 issue of the journal Nature Biomedical Engineering. In our study, we cultured liver, heart, bone, and skin, connected by vascular flow for four weeks. These tissues can be generated from a single human induced pluripotent stem cell, generating a patient-specific chip, a great model for individualized studies of human disease and drug testing. Credit: Keith Yeager/Columbia Engineering “This is a huge achievement for us—we’ve spent ten years running hundreds of experiments, exploring innumerable great ideas, and building many prototypes, and now at last we’ve developed this platform that successfully captures the biology of organ interactions in the body,” said the project leader Gordana Vunjak-Novakovic, University Professor and the Mikati Foundation Professor of Biomedical Engineering, Medical Sciences, and Dental Medicine. Inspired by the Human Body Taking inspiration from how the human body works, the team has built a human tissue-chip system in which they linked matured heart, liver, bone, and skin tissue modules by recirculating vascular flow, allowing for interdependent organs to communicate just as they do in the human body. The researchers chose these tissues because they have distinctly different embryonic origins, structural and functional properties, and are adversely affected by cancer treatment drugs, presenting a rigorous test of the proposed approach. The tissues cultured in the multi-organ chip (skin, heart, bone, liver, and endothelial barrier from left to right) maintained their tissue-specific structure and function after being linked by vascular flow. Credit: Kacey Ronaldson-Bouchard/Columbia Engineering “Providing communication between tissues while preserving their individual phenotypes has been a major challenge,” said Kacey Ronaldson-Bouchard, the study’s lead author and an associate research scientist in Vunjak-Novakovic’s Laboratory for Stem Cells and Tissue Engineering. “Because we focus on using patient-derived tissue models we must individually mature each tissue so that it functions in a way that mimics responses you would see in the patient, and we don’t want to sacrifice this advanced functionality when connecting multiple tissues. In the body, each organ maintains its own environment, while interacting with other organs by vascular flow carrying circulating cells and bioactive factors. So we chose to connect the tissues by vascular circulation, while preserving each individual tissue niche that is necessary to maintain its biological fidelity, mimicking the way that our organs are connected within the body. ” Optimized Tissue Modules Can Be Maintained for More Than a Month The group created tissue modules, each within its optimized environment and separated them from the common vascular flow by a selectively permeable endothelial barrier. The individual tissue environments were able to communicate across the endothelial barriers and via vascular circulation. The researchers also introduced into the vascular circulation the monocytes giving rise to macrophages, because of their important roles in directing tissue responses to injury, disease, and therapeutic outcomes. All tissues were derived from the same line of human induced pluripotent stem cells (iPSC), obtained from a small sample of blood, in order to demonstrate the ability for individualized, patient-specific studies. And, to prove the model can be used for long-term studies, the team maintained the tissues, which had already been grown and matured for four to six weeks, for an additional four weeks, after they were linked by vascular perfusion. Using the Model To Study Anticancer Drugs The researchers also wanted to demonstrate how the model could be used for studies of an important systemic condition in a human context and chose to examine the adverse effects of anticancer drugs. They investigated the effects of doxorubicin — a broadly used anticancer drug — on heart, liver, bone, skin, and vasculature. They showed that the measured effects recapitulated those reported from clinical studies of cancer therapy using the same drug. The team developed in parallel a novel computational model of the multi-organ chip for mathematical simulations of drug’s absorption, distribution, metabolism, and secretion. This model correctly predicted doxorubicin’s metabolism into doxorubicinol and its diffusion into the chip. The combination of the multi-organ chip with computational methodology in future studies of pharmacokinetics and pharmacodynamics of other drugs provides an improved basis for preclinical to clinical extrapolation, with improvements in the drug development pipeline. “While doing that, we were also able to identify some early molecular markers of cardiotoxicity, the main side-effect that limits the broad use of the drug. Most notably, the multi-organ chip predicted precisely the cardiotoxicity and cardiomyopathy that often require clinicians to decrease therapeutic dosages of doxorubicin or even to stop the therapy,” said Vunjak-Novakovic. Collaborations Across the University The development of the multi-organ chip began from a platform with the heart, liver, and vasculature, nicknamed the HeLiVa platform. As is always the case with Vunjak-Novakovic’s biomedical research, collaborations were critical for completing the work. These include the collective talent of her laboratory, Andrea Califano and his systems biology team (Columbia University), Christopher S. Chen (Boston University) and Karen K. Hirschi (University of Virginia) with their expertise in vascular biology and engineering, Angela M. Christiano and her skin research team (Columbia University), Rajesh K. Soni of the Proteomics Core at Columbia University, and the computational modeling support of the team at CFD Research Corporation. A Multitude of Applications, All in Individualized Patient-Specific Contexts The research team is currently using variations of this chip to study, all in individualized patient-specific contexts: breast cancer metastasis; prostate cancer metastasis; leukemia; effects of radiation on human tissues; the effects of SARS-CoV-2 on heart, lung, and vasculature; the effects of ischemia on the heart and brain; and the safety and effectiveness of drugs. The group is also developing a user-friendly standardized chip for both academic and clinical laboratories, to help utilize its full potential for advancing biological and medical studies. Vunjak-Novakovic added, “After ten years of research on organs-on-chips, we still find it amazing that we can model a patient’s physiology by connecting millimeter sized tissues — the beating heart muscle, the metabolizing liver, and the functioning skin and bone that are grown from the patient’s cells. We are excited about the potential of this approach. It’s uniquely designed for studies of systemic conditions associated with injury or disease, and will enable us to maintain the biological properties of engineered human tissues along with their communication. One patient at a time, from inflammation to cancer!” Reference: “A multi-organ chip with matured tissue niches linked by vascular flow” by Kacey Ronaldson-Bouchard, Diogo Teles, Keith Yeager, Daniel Naveed Tavakol, Yimu Zhao, Alan Chramiec, Somnath Tagore, Max Summers, Sophia Stylianos, Manuel Tamargo, Busub Marcus Lee, Susan P. Halligan, Erbil Hasan Abaci, Zongyou Guo, Joanna Jacków, Alberto Pappalardo, Jerry Shih, Rajesh K. Soni, Shivam Sonar, Carrie German, Angela M. Christiano, Andrea Califano, Karen K. Hirschi, Christopher S. Chen, Andrzej Przekwas and Gordana Vunjak-Novakovic, 27 April 2022, Nature Biomedical Engineering. DOI: 10.1038/s41551-022-00882-6 RRG455KLJIEVEWWF |
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