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KoDō 和牛燒肉包廂適合尾牙嗎?》台中公益路美食指南|10家餐廳值得你收藏 |
| 在地生活|大台北 2026/04/20 18:34:14 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人,臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」,從精緻西餐到創意火鍋,從日式丼飯到義式早午餐,每走幾步,就會有完全不同的特色料理餐廳。 這次我特別花了一整個月,實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店,也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準,整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你,找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型,從高質感牛排館到巷弄系早午餐,每一間都有自己獨特的風格。為了讓整體比較更客觀,我依照以下四大面向進行評比,並搭配實際用餐體驗來打分。
整體而言,我希望這份評比不只是「哪家好吃」,而是幫你在不同情境下(約會、家庭聚餐、朋友小聚、商業午餐)都能快速找到合適的選擇。畢竟,美食不只是味覺的滿足,更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段,從火鍋、燒肉到中式料理與早午餐,每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單,橫跨平價、創意、高級各路風格。
一頭牛日式燒肉|炭香濃郁的和牛饗宴,約會聚餐首選
走在公益路上,很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面,搭配昏黃燈光與暖色調的內裝,讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大,但桌距規劃得宜,每桌皆設有獨立排煙設備,烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂,絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網,讓人完全不用分心。整場用餐過程就像一場表演,從視覺、嗅覺到味覺都被滿足。 綜合評分
地址:408臺中市南屯區公益路二段162號電話:04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」,更像是一場五感盛宴。從進門那一刻到最後一道甜點,都能感受到他們對細節的用心。 TANG Zhan 湯棧|文青系火鍋代表,麻香湯底與視覺美感並重
在公益路這條美食戰線上,TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址:408臺中市南屯區公益路二段248號電話:04-22580617 官網:https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度,又結合現代風格與細節服務,讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店,湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店|明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂,那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主,陽光灑進室內,讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧,建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味,選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口,米芯保留微Q口感;而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香,口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹,無論是一個人帶電腦工作、或朋友聚餐,都能找到舒服角落。餐點上桌速度穩定,服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」,很適合想遠離忙碌日常的人。 綜合評分
地址:40861臺中市南屯區公益路二段18號電話:04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇,而是以「剛剛好」的份量與風味,陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店,NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物|平價卻用心的湯頭系火鍋,家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上,加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐,但靠著實在的湯頭與親切的服務,默默吸引許多回頭客。每到用餐時間,總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底,湯頭清澈卻不單薄,越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向,桌距寬敞、座位舒適,帶小孩來也不覺擁擠。店員態度親切,補湯、收盤都很勤快,給人一種「被照顧著」的安心感。 綜合評分
地址:403臺中市西區公益路288號電話:0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤,而是用最簡單的湯頭與新鮮食材,傳遞出家常卻不平凡的溫度。 印月餐廳|中式料理的藝術演繹,宴客與家庭聚會首選
說到臺中公益路的中式料理代表,印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名,把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設,每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏,都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法,讓人感受到「被款待」的尊榮感。 綜合評分
地址:408臺中市南屯區公益路二段818號電話:0422511155 小結語印月餐廳是一間「不只吃飯,更像品味生活」的地方。 KoDō 和牛燒肉|極致職人精神,專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗,一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉,以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址:403臺中市西區公益路260號電話:0423220312 官網:https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳,而是一場體驗。 永心鳳茶|在茶香裡用餐的優雅時光,臺味早午餐的新詮釋
走進 永心鳳茶公益店,彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤,無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」,都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和,對茶品介紹詳盡。上餐節奏剛好,不急不徐。 綜合評分
地址:40360臺中市西區公益路68號三樓(勤美誠品)電話:0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓|老饕級江浙功夫菜,穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主,兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址:408臺中市南屯區公益路二段95號電話:0423202322 官網:https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司|低調奢華的無菜單日料,職人手藝詮釋旬味極致
在熱鬧的公益路上,一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase(無菜單料理) 形式,每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘,節奏緩慢但沉穩。 綜合評分
地址:408臺中市南屯區公益路二段25號電話:0423206368 官網:https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂|人氣爆棚的和牛燒肉聖地,肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳,茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐,價格約落在 $700–$1000 間,份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快,整場用餐流程流暢無壓力。 綜合評分
地址:403臺中市西區公益路268號電話:0423281167 官網:https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質+輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後,臺中公益路不只是一條美食街,而是一段生活風景線。 有的餐廳講究細膩與儀式感,像 一頭牛日式燒肉 與 一笈壽司,讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心,像 加分昆布鍋物、永心鳳茶,讓人明白吃飯不只是為了飽足,而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店,則用穩定的品質與熱絡的氛圍,成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店,構成了公益路最動人的縮影 有華麗的,也有溫柔的;有傳統的,也有創新的。 每一家都在自己的風格裡發光,讓人吃到的不只是料理,而是一種生活的溫度與節奏。 對我而言,這不僅是一場美食旅程,更是一趟關於「臺中味道」的回憶之旅。 FAQ:關於臺中公益路美食常見問題Q1:公益路哪一區的餐廳最集中? Q2:需要提前訂位嗎? 最後的話若要用一句話形容這趟美食之旅,我會說: KoDō 和牛燒肉氣氛如何? 如果你也和我一樣喜歡用味蕾探索一座城市,那就把這篇公益路美食攻略收藏起來吧。印月餐廳整體體驗如何? 無論是約會、慶生、家庭聚餐,或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。NINI 尼尼臺中店調味偏重嗎? 下一餐,不妨從這10家開始。印月餐廳食材新鮮嗎? 打開手機、約上朋友,讓公益路成為你生活裡最容易抵達的小確幸。一笈壽司包廂適合尾牙嗎? 如果你有私心愛店,也歡迎留言分享,TANG Zhan 湯棧食材新鮮嗎? 你的推薦,可能讓我下一趟美食旅程變得更精彩。加分100%浜中特選昆布鍋物有生日驚喜或畫盤嗎? Fluorescent images of human neurons (stained with red, green, and blue) growing on coatings with fast-moving molecules (left) or conventional laminin (right) for 60 days. Neurons spread homogenously and showed more complex branching on the highly mobile coating developed at Northwestern. Credit: Northwestern University Researchers Pushed the Age Limit of Human Neurons Further Than Previously Possible A team of researchers led by Northwestern University has achieved a breakthrough by producing the most mature neurons to date from human induced pluripotent stem cells (iPSCs). This advancement opens up new avenues for medical research and the possibility of transplantation therapies for conditions such as neurodegenerative diseases and traumatic injuries. Previous efforts to turn stem cells into neurons have resulted in functionally immature neurons that resemble those from the early stages of development. The limited maturation achieved through current stem cell culture methods restricts their potential for studying neurodegeneration. The study was recently published in the journal Cell Stem Cell. To create the mature neurons, the team used “dancing molecules,” a breakthrough technique introduced last year by Northwestern professor Samuel I. Stupp. The team first differentiated human iPSCs into motor and cortical neurons and then placed them onto coatings of synthetic nanofibers containing the rapidly moving dancing molecules. Fluorescent image of a human neuron (red) growing on the coating with fast-moving molecules (green) for 60 days. Credit: Northwestern University Not only were the enriched neurons more mature, but they also demonstrated enhanced signaling capabilities and greater branching ability, which is required for neurons to make synaptic contact with one another. And, unlike typical stem cell-derived neurons which tend to clump together, these neurons did not aggregate, making them less challenging to maintain. With further development, the researchers believe these mature neurons could be transplanted into patients as a promising therapy for spinal cord injuries as well as neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease, Alzheimer’s disease, or multiple sclerosis. The mature neurons also present new opportunities for studying neurodegenerative diseases like ALS and other age-related illnesses in culture dish-based in vitro models. By advancing the age of neurons in cellular cultures, researchers could improve experiments to better understand late-onset diseases. Fluorescent images of human neurons (stained with red, green, and blue) growing on coatings with fast-moving molecules (left) or conventional laminin (right) for 72 hours. Neurons attached and spread homogeneously on the highly mobile coating but remained clumped together on the laminin coating. Credit:Northwestern University “This is the first time we have been able to trigger advanced functional maturation of human iPSC-derived neurons by plating them on a synthetic matrix,” said Northwestern’s Evangelos Kiskinis, co-corresponding author of the study. “It’s important because there are many applications that require researchers to use purified populations of neurons. Most stem cell-based labs use mouse or rat neurons co-cultured with human stem cell-derived neurons. But that does not allow scientists to investigate what happens in human neurons because you end up working with a mixture of mouse and human cells.” “When you have an iPSC that you manage to turn into a neuron, it’s going to be a young neuron,” said Stupp, co-corresponding author of the study. “But, in order for it to be useful in a therapeutic sense, you need a mature neuron. Otherwise, it is like asking a baby to carry out a function that requires an adult human being. We have confirmed that neurons coated with our nanofibers achieve more maturity than other methods, and mature neurons are better able to establish the synaptic connections that are fundamental to neuronal function.” Kiskinis is an assistant professor of neurology and neuroscience at Northwestern University Feinberg School of Medicine, a New York Stem Cell Foundation-Robertson Investigator and a core faculty member of the Les Turner ALS Center. Stupp is the Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine and Biomedical Engineering at Northwestern, where he is the founding director of the Simpson Querrey Institute for BioNanotechnology (SQI) and its affiliated research center, the Center for Regenerative Nanomedicine. Stupp has appointments in the McCormick School of Engineering, Weinberg College of Arts and Sciences, and Feinberg School of Medicine. Synchronized ‘Dancing’ Abilities To develop the mature neurons, the researchers used nanofibers composed of “dancing molecules,” a material that Stupp’s lab developed as a potential treatment for acute spinal cord injuries. In previous research published in the journal Science, Stupp discovered how to tune the motion of molecules, so they can find and properly engage with constantly moving cellular receptors. By mimicking the motion of biological molecules, the synthetic materials can communicate with cells. A key innovation of Stupp’s research was discovering how to control the collective motion of more than 100,000 molecules within the nanofibers. Because cellular receptors in the human body can move at swift rates — sometimes at timescales of milliseconds — they become difficult-to-hit moving targets. “Imagine dividing a second into 1,000 time periods,” Stupp said. “That’s how fast receptors could move. These timescales are so fast that they are difficult to grasp.” In the new study, Stupp and Kiskinis found that nanofibers tuned to contain molecules with the most motion led to the most enhanced neurons. In other words, neurons cultured on more dynamic coatings — essentially scaffolds composed of many nanofibers — were also the neurons that became the most mature, least likely to aggregate, and had more intense signaling capabilities. “The reason we think this works is because the receptors move very fast on the cell membrane and the signaling molecules of our scaffolds also move very fast,” Stupp said. “They are more likely to be synchronized. If two dancers are not in sync, then the pairing doesn’t work. The receptors become activated by the signals through very specific spatial encounters. It also is possible that our fast-moving molecules enhance receptor movement, which in turn helps cluster them to benefit signaling.” Neurons With ALS Signature Provide a New Window Into the Disease Stupp and Kiskinis believe their mature neurons will give insights into aging-related illnesses and become better candidates for testing various drug therapies in cellular cultures. Using the dancing molecules, the researchers were able to advance human neurons to much older ages than previously possible, enabling scientists to study the onset of neurodegenerative diseases. As part of the research, Kiskinis and his team took skin cells from a patient with ALS and converted them into patient-specific iPSCs. Then, they differentiated those stem cells into motor neurons, which is the cell type afflicted in this neurodegenerative disease. Finally, the researchers cultured neurons on the novel synthetic coating materials to further develop ALS signatures. Not only did this give Kiskinis a new window into ALS, but these “ALS neurons” also could be used to test potential therapies. “For the first time, we have been able to see adult-onset neurological protein aggregation in the stem cell-derived ALS patient motor neurons. This represents a breakthrough for us,” Kiskinis said. “It’s unclear how the aggregation triggers the disease. It’s what we are hoping to find out for the first time.” Hopes for Future Treatment for Spinal Cord Injuries, Neurodegenerative Diseases Further down the road, iPSC-derived mature, enhanced neurons also could be transplanted into patients with spinal cord injuries or neurodegenerative diseases. For example, physicians could take skin cells from a patient with ALS or Parkinson’s disease, convert them into iPSCs, and then culture those cells on the coating to create healthy, highly functional neurons. Transplanting healthy neurons into a patient could replace damaged or lost neurons, potentially restoring lost cognition or sensations. And, because the initial cells came from the patient, the new, iPSC-derived neurons would genetically match the patient, eliminating the possibility of rejection. “Cell replacement therapy can be very challenging for a disease like ALS, as transplanted motor neurons in the spinal cord will need to project their long axons to the appropriate muscle sites in the periphery but could be more straightforward for Parkinson’s disease,” Kiskinis said. “Either way this technology will be transformative.” “It is possible to take cells from a patient, transform them into stem cells and then differentiate them into different types of cells,” Stupp said. “But the yield for those cells tends to be low, and achieving proper maturation is a big issue. We could integrate our coating into large-scale manufacturing of patient-derived neurons for cell transplantation therapies without immune rejection.” References: “Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons” by Zaida Álvarez, J. Alberto Ortega, Kohei Sato, Ivan R. Sasselli, Alexandra N. Kolberg-Edelbrock, Ruomeng Qiu, Kelly A. Marshall, Thao Phuong Nguyen, Cara S. Smith, Katharina A. Quinlan, Vasileios Papakis, Zois Syrgiannis, Nicholas A. Sather, Chiara Musumeci, Elisabeth Engel, Samuel I. Stupp and Evangelos Kiskinis, 12 January 2023, Cell Stem Cell. DOI: 10.1016/j.stem.2022.12.010 “Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury” by Z. Álvarez, A. N. Kolberg-Edelbrock, I. R. Sasselli, J. A. Ortega, R. Qiu, Z. Syrgiannis, P. A. Mirau, F. Chen, S. M. Chin, S. Weigand, E. Kiskinis and S. I. Stupp, 11 November 2021, Science. DOI: 10.1126/science.abh3602 The study was funded by the National Institutes of Health, the Les Turner ALS Foundation, the New York Stem Cell Foundation, the U.S. Department of Energy, and Paralyzed Veterans of America Research Foundation. iBioFAB accelerates the biological engineering process by integrating artificial intelligence/machine learning with automation. Credit: Julia Pollack Researchers were able to discover and characterize new ribosomally synthesized and post-translationally modified peptides at an unprecedented speed and scale. Modern medicine makes extensive use of drugs that bacteria naturally produce. One of the most noteworthy natural products is penicillin, an antibiotic developed from certain molds that is regarded as one of the most significant developments in medicine and human health. Scientists now have access to hundreds of thousands of microbial genomes and the natural compounds they make as DNA sequencing has gotten more inexpensive and quick. However, according to Doug Mitchell (MMG), the John and Margaret Witt Professor of Chemistry at the University of Illinois, this is insignificant when compared to the number of compounds that these organisms are capable of producing by using the genetic pathways they possess. “This is just the tip of the iceberg,” said Mitchell. “There’s a disparity in what we know today in terms of known molecules versus what nature has the capacity to produce. Like 100 to one at least.” Ribosomally produced and post-translationally modified peptides, or simply “RiPPs,” are one kind of natural product that has become a popular source of antibiotics. Traditional approaches for accessing RiPPs are laborious and include inserting each gene into a model organism, such as E. coli, one at a time, to observe what compound it produces. However, utilizing the Illinois Biological Foundry for Advanced Biomanufacturing, researchers were able to find and characterize new RiPPs at an unprecedented speed and scale in a recent study that was the outcome of a major joint effort at the Carl R. Woese Institute for Genomic Biology. iBioFAB is a lab automation system that can analyze and create many synthetic gene pathways from hundreds of genes at once, a task that would typically need numerous researchers and a lot more time to do. This study is a partnership between Mitchell’s lab, the lab of Huimin Zhao (BSD/GSE leader/CABBI/CGD/MMG), the Steven L. Miller Chair of chemical and biomolecular engineering, and the lab of Wilfred van der Donk (MMG), Richard E. Heckert Endowed Chair in Chemistry and Howard Hughes Medical Institute Investigator. In a new paper resulting from a massive collaborative effort at the University of Illinois Urbana-Champaign, researchers were able to discover and characterize new ribosomally synthesized and post-translationally modified peptides (RiPPs) at an unprecedented speed and scale using the Illinois Biological Foundry for Advanced Biomanufacturing. Credit: Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign The three co-first authors, Alex Battiste, a fourth-year Ph.D. student in the Mitchell lab, Chengyou Shi, a fifth-year Ph.D. candidate in the Zhao lab, and Richard Ayikpoe, a postdoc in the van der Donk lab, described how they each led a part of the project in their respective labs. Shi’s team ordered synthetic genes and then assembled them into candidate pathways, or gene clusters, using iBioFAB integrated with a genome mining program called RODEO. Then, different classes of the gene clusters were given to Battiste and Ayikpoe’s teams to test which pathways were functional and likely to produce new RiPPs in E. coli. Any structures of RiPPs that showed antibiotic activities were characterized in detail by Ayikpoe’s team. The high-throughput technology allowed for 96 pathways comprised of about 400 genes to be tested at once, with the production of 30 new compounds. “Compared with traditional RiPP discovery methods, our platform is scalable and high-throughput in many aspects, from the biosynthetic gene cluster identification, the cloning, the production, and detection and characterization,” said Shi. “This, I would say, is the first such platform for large-scale RiPP discovery.” Fighting Drug-Resistant Bacteria Out of the new compounds discovered, three were found to have antibacterial properties. When tested against Klebsiella pneumoniae, which are highly virulent antibiotic-resistant bacteria, the newly discovered antibacterial RiPPs were found to be effective at killing the dangerous bacteria. The researchers say this could be a new avenue for discovering compounds that are effective against bacteria that are resistant to current antibiotic drugs. “We found three RiPPs that have antimicrobial properties against pathogens that are known to be involved in hospital-acquired infections, including Klebsiella,” said Ayikpoe. “This research shows that by using this platform to extend the number of biosynthetic gene clusters that we can screen at once, we are more likely to discover anti-microbial compounds that could have therapeutic properties.” The team says the goal of the paper is two-fold: to demonstrate the ability of the high-throughput technology to quickly construct and test gene clusters for new RiPPs, but also to emphasize the kind of large-scale collaborative projects that are made possible within the IGB. “There’s no way that any one of our labs could have done all of this on their own. The IGB has provided the crucible for this kind of interdisciplinary research,” Mitchell said. A Platform for Discovery and Growth Battiste described how the IGB inspires collaborative projects like this one naturally through its design. “The IGB makes it very easy to just talk to people when you see them all the time in your theme, which lowers the barrier for starting projects with them,” Battiste said. “Everyone in the MMG theme works on similar stuff even if we’re from different labs. So we all have different types of expertise but they mesh well together, and you get to learn about the types of techniques they’re using. It’s been one of my favorite parts of working here, the sense of camaraderie amongst all of the people on the team.” All three co-first authors described how their education, research, and job prospects have benefitted greatly from their time at the IGB, highlighting that it is both the people and the technology together that make IGB a great place to conduct research. “The collaborative atmosphere that the IGB offers in diversity and growth, both in terms of science and social life, is really remarkable,” said Ayikpoe. Reference: “A scalable platform to discover antimicrobials of ribosomal origin” by Richard S. Ayikpoe, Chengyou Shi, Alexander J. Battiste, Sara M. Eslami, Sangeetha Ramesh, Max A. Simon, Ian R. Bothwell, Hyunji Lee, Andrew J. Rice, Hengqian Ren, Qiqi Tian, Lonnie A. Harris, Raymond Sarksian, Lingyang Zhu, Autumn M. Frerk, Timothy W. Precord, Wilfred A. van der Donk, Douglas A. Mitchell, and Huimin Zhao, 17 October 2022, Nature Communications. DOI: 10.1038/s41467-022-33890-w The study was funded by the National Institutes of Health. A new study has uncovered that three recessive genes are responsible for the orange color in carrots, offering insights into carrot breeding and health benefits. The research traces the carrot’s journey from its Asian origins in the 9th century to the prevalence of orange carrots in Europe from the 15th century, emphasizing their appealing color and flavor. A study of the genome provides insights into pigmentation and domestication. A recent study analyzing the genetic sequences of over 600 carrot varieties has revealed that the orange color in carrots is determined by three specific genes. Interestingly, for carrots to display this orange hue, these genes must be in a recessive state, essentially switched off. This discovery offers valuable insights into key traits for enhancing carrots, potentially leading to improved health benefits from this vegetable. “Normally, to make some function, you need genes to be turned on,” said Massimo Iorizzo, an associate professor of horticultural science with North Carolina State University’s Plants for Human Health Institute and co-corresponding author of a paper describing the work, published in Nature Plants. “In the case of the orange carrot, the genes that regulate orange carotenoids – the precursor of vitamin A that have been shown to provide health benefits – need to be turned off.” Carrots and Health: A Colorful Connection Carrots, especially orange carrots, contain high quantities of carotenoids, which can help reduce the risk of diseases like eye disease. The orange carrot is the most abundant plant source of pro-vitamin A in the American diet. NC State researchers worked with colleagues from the University of Wisconsin-Madison to sequence 630 carrot genomes in a continuing examination of the history and domestication of the orange carrot; a 2016 study published in Nature Genetics by these researchers provided the first carrot genome sequence and uncovered the gene involved in the pigmentation of yellow carrot. Massimo Iorizzo examines orange carrots to learn more about their pigmentation and domestication. Credit: Photo courtesy of Massimo Iorizzo The researchers performed so-called selective sweeps – structural analyses among five different carrot groups to find areas of the genome that are heavily selected in certain groups. They found that many genes involved in flowering were under selection – mostly to delay the flowering process. Flowering causes the taproot, the edible root that we consume, to turn woody and inedible. Selection and Domestication of the Orange Carrot “We found many genes involved in flowering regulation that were selected in multiple populations in orange carrot, likely to adapt to different geographic regions,” Iorizzo said. The study also adds further evidence that carrots were domesticated in the 9th or 10th century in western and central Asia. “Purple carrots were common in central Asia along with yellow carrots,” Iorizzo said. “Both were brought to Europe, but yellow carrots were more popular, likely due to their taste.” Orange carrots made their appearance in Western Europe in about the 15th or 16th century. The orange carrot may have resulted from crossing a white and yellow carrot, Iorizzo said. “This study basically reconstructed the chronology of when carrot was domesticated and then orange carrot was selected,” he said. “Orange carrot could have resulted from white and yellow carrot crosses, as white and yellow carrots are at the base of the phylogenetic tree for the orange carrot.” The Rise of the Orange Carrot The color and sweeter flavor of the orange carrot drove its popularity and farmers selected for those traits. Different types of orange carrots were developed in northern Europe in the 16th and 17th centuries, which matches the appearance of different shades of orange carrots in paintings from that era. Orange carrots later grew in popularity as a greater understanding of alpha- and beta-carotenes, the precursor of vitamin A in the diet, progressed in the late 19th and early 20th centuries. “Carotenoids got their name because they were first isolated from carrots,” Iorizzo said. Reference: “Population genomics identifies genetic signatures of carrot domestication and improvement and uncovers the origin of high-carotenoid orange carrots” by Kevin Coe, Hamed Bostan, William Rolling, Sarah Turner-Hissong, Alicja Macko-Podgórni, Douglas Senalik, Su Liu, Romit Seth, Julien Curaba, Molla Fentie Mengist, Dariusz Grzebelus, Allen Van Deynze, Julie Dawson, Shelby Ellison, Philipp Simon and Massimo Iorizzo, 28 September 2023, Nature Plants. DOI: 10.1038/s41477-023-01526-6 Philipp Simon from the University of Wisconsin-Madison is the paper’s co-corresponding author. Kevin Coe, Hamed Bostan, William Rolling, Sarah Turner-Hissong, Alicja Macko-Podgórni, Douglas Senalik, Su Liu, Romit Seth, Julien Curaba, Molla Fentie Mengist, Dariusz Grzebelus, Allen Van Deynze, Julie Dawson and Shelby Ellison co-authored the paper. The research was supported by National Institute of Food and Agriculture, U.S. Department of Agriculture (NIFA-USDA), under award numbers 2016-51181-25400, 2022-51181-38321 and Hatch project 1008691. RRG455KLJIEVEWWF |
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