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文章數：107 |
 茶六燒肉堂尾牙聚餐表現如何？》台中公益路美食指南｜10家餐廳值得你收藏 |
| 在地生活｜大台北 2026/04/21 19:29:42 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 永心鳳茶調味偏重嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。TANG Zhan 湯棧口味偏臺式還是日式？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。加分100%浜中特選昆布鍋物適合聚餐嗎？ 下一餐，不妨從這10家開始。永心鳳茶值得推薦嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。印月餐廳份量足夠嗎？ 如果你有私心愛店，也歡迎留言分享，加分100%浜中特選昆布鍋物好吃嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。茶六燒肉堂單點比較好嗎？ A new study offers insights into brain development by mapping DNA modifications, aiding in the understanding of conditions like autism and schizophrenia from early stages. Credit: SciTechDaily.com UCLA researchers have developed a detailed map of brain development, focusing on DNA modification in the hippocampus and prefrontal cortex to understand mental health origins. This map is crucial for pinpointing the genetic underpinnings of neuropsychiatric conditions like schizophrenia, autism spectrum disorder. Gene Regulation in Brain Development A UCLA-led study has revealed unprecedented insights into how gene regulation evolves during human brain development, illustrating the critical role of the 3D structure of chromatin—comprising DNA and proteins. This groundbreaking research provides new perspectives on how early brain development influences lifelong mental health. Published today (October 9) in Nature, the study was led by Dr. Chongyuan Luo at UCLA and Dr. Mercedes Paredes at UC San Francisco, in collaboration with researchers from the Salk Institute, UC San Diego, and Seoul National University. They produced the first-ever map of DNA modification in the hippocampus and prefrontal cortex—key areas of the brain essential for learning, memory, and emotional regulation. These regions are also commonly associated with disorders such as autism and schizophrenia. Potential Impact on Neuropsychiatric Disorders The researchers hope the data resource, which they’ve made publicly available through an online platform, will be a valuable tool scientists can use to connect genetic variants associated with these conditions to the genes, cells and developmental periods that are most sensitive to their effects. “Neuropsychiatric disorders, even those emerging in adulthood, often stem from genetic factors disrupting early brain development,” said Luo, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. “Our map offers a baseline to compare against genetic studies of diseased-affected brains and pinpoint when and where molecular changes occur.” Fluorescent image of a developing human hippocampus. Credit: Oier Pastor-Alonso/UCSF Innovations in Epigenetic Research Techniques To produce the map, the research team used a cutting-edge sequencing approach Luo developed and scaled with support from the UCLA Broad Stem Cell Research Center Flow Cytometry Core called single nucleus methyl-seq and chromatin conformation capture, or snm3C-seq. This technique enables researchers to simultaneously analyze two epigenetic mechanisms that control gene expression on a single-cell basis: chemical changes to DNA known as methylation and chromatin conformation, the 3D structure of how chromosomes are tightly folded to fit into nuclei. Figuring out how these two regulatory elements act on genes that affect development is a critical step to understanding how errors in this process lead to neuropsychiatric conditions. Linking Genetic Variants to Gene Regulation “The vast majority of disease-causing variants we’ve identified are located between genes on the chromosome, so it’s challenging to know which genes they regulate,” said Luo, who is also an assistant professor of human genetics at the David Geffen School of Medicine at UCLA. “By studying how DNA is folded inside of individual cells, we can see where genetic variants connect with certain genes, which can help us pinpoint the cell types and developmental periods most vulnerable to these conditions.” For example, autism spectrum disorder is commonly diagnosed in children aged 2 and over. However, if researchers can gain a better understanding of the genetic risk of autism and how it impacts development, they can potentially develop intervention strategies to help alleviate the symptoms of autism, like communication challenges, while the brain is developing. Insights From a Broad Developmental Spectrum The research team analyzed more than 53,000 brain cells from donors spanning mid-gestation to adulthood, revealing significant changes in gene regulation during critical developmental windows. In capturing such a broad spectrum of developmental phases, the researchers were able to assemble a remarkably comprehensive picture of the massive genetic rewiring that occurs during critical timepoints in human brain development. One of the most dynamic periods comes around the midpoint of pregnancy. At this time, neural stem cells called radial glia, which have produced billions of neurons during the first and second trimesters, stop producing neurons and begin generating glial cells, which support and protect neurons. At the same time, the newly formed neurons mature, gaining the characteristics they need to fulfill specific functions and forming the synaptic connections that enable them to communicate. This stage of development has been overlooked in previous studies, the researchers say, due to the limited availability of brain tissue from this period. “Our study tackles the complex relationship between DNA organization and gene expression in developing human brain at ages typically not interrogated: the third trimester and infancy,” said Paredes, an associate professor of neurology at UCSF. “The connections we’ve identified across different cell types through this work could untangle the current challenges in identifying meaningful genetic risk factors for neurodevelopmental and neuropsychiatric conditions.” Implications for Brain Development Models The findings also have implications for improving stem cell-based models, such as brain organoids, which are used to study brain development and diseases. The new map offers a benchmark for scientists to ensure these models accurately replicate human brain development. “Growing a healthy human brain is a tremendous feat,” says co-author Dr. Joseph Ecker, professor at the Salk Institute and Howard Hughes Medical Institute investigator. “Our study establishes an important database that captures key epigenetic changes that occur during brain development, in turn bringing us closer to understanding where and when failures arise in this development that can lead to neurodevelopmental disorders like autism.” Reference: “Temporally distinct 3D multi-omic dynamics in the developing human brain” by Matthew G. Heffel, Jingtian Zhou, Yi Zhang, Dong-Sung Lee, Kangcheng Hou, Oier Pastor-Alonso, Kevin D. Abuhanna, Joseph Galasso, Colin Kern, Chu-Yi Tai, Carlos Garcia-Padilla, Mahsa Nafisi, Yi Zhou, Anthony D. Schmitt, Terence Li, Maximilian Haeussler, Brittney Wick, Martin Jinye Zhang, Fangming Xie, Ryan S. Ziffra, Eran A. Mukamel, Eleazar Eskin, Tomasz J. Nowakowski, Jesse R. Dixon, Bogdan Pasaniuc, Joseph R. Ecker, Quan Zhu, Bogdan Bintu, Mercedes F. Paredes and Chongyuan Luo, 9 October 2024, Nature. DOI: 10.1038/s41586-024-08030-7 The group’s efforts were supported by the National Institutes of Health’s BRAIN Initiative Cell Atlas Network, or BICAN, which aims to build reference brain cell atlases that will provide a foundational framework for studying brain function and disorders. Funding was also provided by the National Institute of Mental Health, the National Human Genome Research Institute, the Simons Foundation, the Roberta and Oscar Gregory Endowment in Stroke and Brain Research, the Chan Zuckerberg Biohub, the National Research Foundation of Korea, the Shurl and Kay Curci Foundation, National Institute on Drug Abuse and the California Institute for Regenerative Medicine. Additional authors are: Jingtian Zhou, Yi Zhang, Dong-Sung Lee, Kangcheng Hou, Oier Pastor Alonso, Kevin D Abuhanna, Joseph Galasso, Colin Kern, Chu-Yi Tai, Carlos Garcia Padilla, Mahsa Nafisi, Yi Zhou, Anthony D. Schmitt, Terence Li, Maximilian Haeussler, Brittney Wick, Martin Jinye Zhang, Fangming Xie, Ryan S. Ziffra, Eran A. Mukamel, Eleazar Eskin, Tomasz J. Nowakowski, Jesse R. Dixon, Bogdan Pasaniuc, Joseph R. Ecker, Quan Zhu, and Bogdan Bintu. Research on stick insects shows short-term predictable evolution, but long-term changes introduce unpredictability due to random events and new mutations. Researchers present evidence of repeatable evolutionary patterns in California’s stick insect populations, demonstrating that while short-term evolution can be predictable due to constant environmental pressures like predation, long-term evolutionary outcomes involve more randomness due to events like mutations and climatic changes. Among evolutionary scientists there is a long-standing debate that goes something like this: Does evolution happen in a predictable pattern or does it depend on chance events and contingency? That is, if you could turn back the clock, as celebrated scientist Stephen Jay Gould (1941-2002) described in his famous metaphor, “Replaying the Tape of Life,” would life on Earth evolve, once again, as something similar to what we know now, or would it look very, very different? A shrub jay with a Timema stick insect in its beak. Credit: Henri Truchassout The Complexity of Evolution “If you frame it as an either/or question, it’s too simplistic,” says Utah State University evolutionary biologist Zachariah Gompert. “The answer isn’t ‘completely random’ or ‘completely deterministic and predictable.’ And yet, examining short time scales, we can find predictable, repeatable evolutionary patterns.” Gompert and colleagues report evidence of repeatable evolution in populations of stick insects in the May 24, 2024, online edition of the American Association for the Advancement of Science’s journal Science Advances. Collaborating authors on the paper include Gompert’s long-time collaborator Patrik Nosil and other researchers from France’s University of Montpelier, Brazil’s Federal University of São Paulo, the University of Nevada, Reno, and Notre Dame University. The research is supported by the National Science Foundation and the European Research Council. A green Timema cristinae morph stick insect blends in with California lilac shrub (Ceanothus spinosus). Credit: Aaron Comeault Research Findings on Stick Insects The team examined three decades of data on the frequency of cryptic color-pattern morphs in the stick insect species Timema cristinae in ten naturally replicate populations in California. T. cristinae is polymorphic in regard to its body color and pattern. Some insects are green, which allows the wingless, plant-feeding insect to blend in with California lilac (Ceanothus spinosus) shrubs. In contrast, green striped morphs disappear against chamise (Adenostoma fasciculatum) shrubs. Hiding amongst the plants is one of T. christinae’s key defenses as hungry birds, such as scrub jays, are insatiable predators of the stick insects. A striped Timema cristinae morph stick insect blends in with a chamise shrub (Adenostoma fasciculatum). Credit: Moritz Muschick Evolutionary Patterns and Natural Selection “Bird predation is a constant driver shaping the insects’ organismal traits, including coloration and striped vs. non-striped,” says Gompert, associate professor in USU’s Department of Biology and the USU Ecology Center. “We observed predictable ‘up-and-down’ fluctuations in stripe frequency in all populations, representing repeatable evolutionary dynamics based on standing genetic variation.” He says a field experiment demonstrates these fluctuations involved negative frequency-dependent natural selection (NFDS), where cryptic color patterns are more beneficial when rare rather than common. This is likely because birds develop a ‘search image’ for the most common prey. Utah State University biologist Zach Gompert and colleagues observe recurring evolutionary changes, over time in stick insects; publish findings in the May 24, 2024, edition of Science Advances. Credit: M. Muffoletto Predictability and Randomness in Evolution “At short time scales, evolution involving existing variations can be quite predictable,” says Gompert, who received a National Science Foundation CAREER grant in 2019 to support his research. “You can count on certain drivers always being there, such as birds feeding on the insects.” But at longer time scales, evolutionary dynamics become less predictable. “The populations might experience a chance event, such as a severe drought or a flooding event, that disrupts the status quo and thus, the predictable outcomes,” Gompert says. Challenges in Evolutionary Studies On long time scales, a new mutation in the species could introduce a rare trait, he says. “That’s about as close to truly random as you can get.” “Rare things are easily lost by chance, so there’s a strong probability a new mutation could disappear before it gains a stronghold,” he says. “Indeed, another species of Timema stick insect that also feeds on chamise either never had or quickly lost the mutations making the cryptic stripe trait. Thus, the evolution of stripe is not a repeatable outcome of evolution at this long scale.” Gompert notes replicated, long-term studies from natural populations, including research on the famous Darwin’s finches, are rare. “Because most of this work is restricted to one or few populations, it is difficult to draw inferences on repeatability among multiple evolutionary independent populations,” he says. “Such studies are challenging to implement not only because they take concerted effort, but also because you can’t rush time.” Reference: “Evolution repeats itself in replicate long-term studies in the wild” by Patrik Nosil, Clarissa F. de Carvalho, Romain Villoutreix, Laura S. Zamorano, Marion Sinclair-Waters, Nicholas P. Planidin, Thomas L. Parchman, Jeffrey Feder and Zach Gompert, 24 May 2024, Science Advances. DOI: 10.1126/sciadv.adl3149 Gompert, who is designated a High Ranked Scholar by ScholarGPS, has developed, with USU colleagues, a research-intensive, interactive introductory biology laboratory class to introduce undergraduates to research. He and colleagues also developed an interactive presentation about evolution for all ages, called “Nabokov’s Butterflies,” that was presented at the USU College of Science’s Science Unwrapped public outreach program in 2022. A newly identified neuron type, BNC2, quickly inhibits hunger signals in the brain, offering insights into faster satiety responses and potential obesity treatments, fundamentally altering our understanding of appetite control. Scientists have discovered a new type of neuron, BNC2, that acts as an immediate counterbalance to hunger neurons, offering a fast-acting mechanism for satiety. This finding, which expands our understanding of appetite regulation, could lead to new treatments for obesity and metabolic disorders. As you decide whether to eat another potato chip, a fierce battle unfolds in your brain. One group of neurons drives hunger, while another signals fullness. How quickly one side gains the upper hand determines whether you’ll put down the bag of chips. Now, scientists have discovered a missing link in this neural circuit governing hunger and satiety—a previously unidentified type of neuron that serves as an immediate counterbalance to the urge to eat. The findings, published in Nature, expand the classic model of hunger and satiety regulation, and may provide new therapeutic targets for tackling obesity and metabolic disorders. “This new type of neuron changes the conceptual framework for how feeding is regulated,” says Han Tan, a research associate in Rockefeller’s Laboratory of Molecular Genetics, headed by Jeffrey Friedman. More or less Traditionally, the brain’s so-called feeding circuit was thought to involve a simple feedback loop between two types of brain cells in the hypothalamus: neurons expressing a gene named AGRP drive hunger, and neurons expressing a gene named POMC promote satiety. Previously these two populations were thought to be the two main targets of leptin but recent studies suggested that this model was incomplete. While activating AGRP neurons rapidly induces appetite, activating POMC neurons takes hours to suppress appetite. Researchers wondered whether they had missed something. “We suspected POMC couldn’t counterbalance the hunger neurons quickly enough to curb feeding,” Tan says. “So we wondered if there was a missing neuron that could promote rapid satiety, on a similar timescale to that of AGRP.” “Hunger” neurons expressing the AGRP gene (red), alongside newly-discovered “satiety” neurons expressing the BNC2 gene (green). Credit: Laboratory of Molecular Genetics at The Rockefeller University Through single-cell RNA sequencing of neurons in the brain’s arcuate nucleus, the team identified a new type of neuron that expresses a gene called BNC2 together with receptors for the hormone leptin, which has previously been shown to play a significant role in regulating body weight. This newly discovered BNC2 neuron rapidly responds to food cues and acts to rapidly inhibit hunger. The findings reveal that BNC2 neurons, when activated by leptin and possibly other signals, not only suppress appetite but also alleviate the negative feelings associated with hunger. Remarkably, these neurons act by inhibiting the AGRP neurons and they can do so rapidly, serving as a complementary signal. “This study has added an important new component to the neural circuit that regulates appetite and broadens our understanding of how leptin reduces appetite,” Friedman says. “It also solves a mystery about how feeding is regulated on different time scales by different neurons.” Redefining hunger The discovery of BNC2 neurons has broad implications for tackling obesity and metabolic disorders. “We are actively researching whether targeting these neurons could provide a new therapy for obesity or diabetes,” Tan says, pointing to genetic studies that link BNC2 to high body mass index and diabetes risk in patients. The team is also exploring how stimulating or inhibiting these neurons affects glucose and insulin levels, further underscoring the therapeutic potential of modulating their activity. This discovery could also have broad implications for how we understand the brain’s control over instinctive behaviors. If BNC2 neurons can coordinate hunger regulation, could there be other similar circuits for behaviors like grooming or sleeping? Identifying similar circuits could deepen our understanding of how the brain choreographs complex actions across different instinctive behaviors, paving the way for further discoveries in behavioral neuroscience. “We now believe BNC2 and AGRP to be the sort of yin and yang of feeding,” Tan says. Reference: “Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake” by Han L. Tan, Luping Yin, Yuqi Tan, Jessica Ivanov, Kaja Plucinska, Anoj Ilanges, Brian R. Herb, Putianqi Wang, Christin Kosse, Paul Cohen, Dayu Lin and Jeffrey M. Friedman, 30 October 2024, Nature. DOI: 10.1038/s41586-024-08108-2 RRG455KLJIEVEWWF |
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