|
|
文章數：81 |
 三希樓調味偏重嗎？》公益路絕對要吃的10家餐廳｜台中人私藏推薦 |
| 在地生活｜大台北 2026/04/19 01:19:07 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 一笈壽司用餐時間會不會太短？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。TANG Zhan 湯棧調味偏重嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。永心鳳茶適合跨年聚餐嗎？ 下一餐，不妨從這10家開始。一頭牛日式燒肉用餐環境舒服嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。TANG Zhan 湯棧肉質如何？ 如果你有私心愛店，也歡迎留言分享，一笈壽司適合聚餐嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。印月餐廳適合聚餐嗎？ Rather than a tracking tag telling scientists where this shark traveled, its violent removal let them observe an unexpected regeneration process. Credit: Josh Schellenberg, CC BY-ND During a migration study, a researcher discovered a silky shark in Florida regenerating its dorsal fin, highlighting the species’ extraordinary healing powers. I made an accidental and astonishing discovery while studying the movements of sharks off the coast of Jupiter, Florida. I set out to record the migration routes of silky sharks, named for their smooth skin. Instead, in a story filled with twists and turns, I ended up documenting the rare phenomenon of a shark regenerating a dorsal fin. Tagging, Then Trauma It all started in the summer of 2022, when my team and I tagged silky sharks (Carcharhinus falciformis) as part of my Ph.D. research. Silky sharks are commonly found in the open ocean and grow to be 10 feet long. Scientists know these sharks congregate in South Florida each summer, but where they go the rest of the year remains a mystery – one I hoped to solve. Chelsea Black, center, leads a satellite tagging team from the University of Miami in June 2022. Credit: Tanner Mansell, CC BY-ND Local boat captain John Moore took us to a site where sharks are known to gather. We carefully caught and gently attached GPS trackers to the dorsal, or top, fin of 10 silky sharks. The tags, which are attached like large earrings, do not interfere with swimming and are designed to fall off after a few years. When the tag’s antenna breaks the surface of the water, its GPS location is picked up by overhead satellites, hopefully revealing details of the shark’s secret life. I headed home to track their travels from my laptop. The story took an unexpected turn a few weeks later, when I received disturbing photos from an avid diver and underwater photographer, Josh Schellenberg, who knew of my work. The first sighting of the wounded silky shark in July 2022. Credit: Josh Schellenberg, CC BY-ND The photos showed a male silky shark with a large, gaping wound in its dorsal fin, as if someone had taken a satellite-tag-shaped cookie cutter and punched it right through. Josh wondered if this individual was one of the sharks from my study. When placing the GPS tags, I also place a second tag beneath each shark’s dorsal fin that displays a unique ID number, so I was able to confirm the injured shark was one from my study, #409834. I felt a mixture of relief and sadness. Relief that the shark survived this ordeal; sadness for the scientific data that would now go uncollected. Silky sharks are often caught by local fishermen in this area but are protected in Florida and illegal to kill or retain. Josh’s photos of #409834 showed several hooks in his mouth, so I knew this animal had been captured several times since my team tagged him. The way the satellite tag attaches means it’s impossible for it to naturally rip out of the fin and leave a wound of this shape. Why someone cut off the shark’s satellite tag remains a mystery, but perhaps they thought they could resell it or possibly wanted to interfere with research. I never expected to see that shark again. The Return of #409834 Flash forward to one year later, the summer of 2023. I received several photos of silky sharks from John Moore, our boat captain, who is also an avid diver. John was on the lookout for any of our sharks making their seasonal return to Jupiter. In the many shark photos he sent, I noticed a silky shark with an oddly shaped dorsal fin. Shark #409834 spotted a year later, in June 2023, with a healed dorsal fin. Credit: Josh Schellenberg, CC BY-ND I knew immediately it had to be #409834 from the previous summer. A few days later, John was able to get close enough to photograph the ID tag to confirm my hunch. Josh Schellenberg also spotted and photographed #409834. With both John’s and Josh’s photos, I was able to compare the healed dorsal fin with the freshly injured one. I wasn’t expecting to make a groundbreaking discovery. Simple curiosity led me to start analyzing the photos. But the revelation was astonishing: Not only had the wound completely healed, but the 2023 dorsal fin was 10.7% larger in size than it was after the injury in 2022. New fin tissue had regenerated. Changes in the dorsal fin from 2022 and 2023. Credit: Josh Schellenberg and John Moore, CC BY-ND My analysis determined that within 332 days, the shark regenerated enough tissue that his dorsal fin was almost back to 90% of its original size, growing back more than half of what had been cut off in 2022. The dorsal fin, pivotal for balance, steering, and hydrodynamics, is vital for a shark to be able to hunt and survive. Seeing no infection or any signs of malnourishment in #409834 suggests an extraordinary feat of endurance. Scientists know that sharks have an incredible aptitude for healing – but mechanisms behind these observations are still poorly understood. While limb regeneration has been widely documented in other marine animals like starfish and crabs, there is only one other documented case of dorsal fin regeneration in a shark – a whale shark in the Indian Ocean that regrew its dorsal fin after a boat accident in 2006. 400 Million Years of Resilience There’s a reason sharks have been on Earth longer than trees and have survived multiple mass extinction events that wiped out other species. They are a product of 400 million years of evolutionary adaptations that demonstrate their remarkable resilience and have primed them for survival. To be able to pinpoint an ability that helps make them so resilient is a major scientific advance – especially considering scientists are still questioning where silky sharks spend most of their time in the Atlantic. One person’s attempt to undermine shark science and harm a shark ultimately proved futile. Instead, the shark’s toughness prevailed and led to an amazing discovery about this species. This story also shows there are countless individual people, including scientists like me and shark enthusiasts like Josh and John, who share a genuine love and respect for these animals. While I’ll never know for certain where #409834 spends the rest of the year, I hope he continues to return to Jupiter each summer so we can further assess his progress. Based on the healing rate calculated in my study, we just might see his dorsal fin grow back to 100% its original size. Written by Chelsea Black, Ph.D. Candidate in Marine Ecosystems and Society, University of Miami. Adapted from an article originally published in The Conversation. Aging might be more related to gene length than the specific functions of genes, with decreased expression of long genes across species marking a key factor in aging and related diseases. This discovery opens new avenues for anti-aging research and interventions. Credit: SciTechDaily.com Aging may be less about specific “aging genes” and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece publishing March 21 in the journal Trends in Genetics. A decline in the expression of long genes with age has been observed in a wide range of animals, from worms to humans, in various human cell and tissue types, and also in individuals with neurodegenerative disease. Mouse experiments show that the phenomenon can be mitigated via known anti-aging factors, including dietary restriction. “If you ask me, this is the main cause of systemic aging in the whole body,” says co-author and molecular biologist Jan Hoeijmakers of the Erasmus University Medical Center, Rotterdam; the University of Cologne; and Oncode Institute/Princess Maxima Institute, Utrecht. The authors span four research groups from Spain, the Netherlands, Germany, and the United States, with each group arriving at the same conclusions using different methods. Aging at the Molecular Level Aging is associated with changes at the molecular, cellular, and organ level—from altered protein production to sub-optimal cell metabolism to compromised tissue architecture. These changes are thought to originate from DNA damage resulting from cumulative exposure to harmful agents such as UV radiation or reactive oxygen species generated by our own metabolism. While a lot of research in aging has focused on specific genes that might accelerate or slow aging, investigations of exactly which genes are more susceptible to aging have revealed no clear pattern in terms of gene function. Instead, susceptibility seems to be linked to the genes’ lengths. “For a long time, the aging field has been focused on genes associated with aging, but our explanation is that it is much more random—it’s a physical phenomenon related to the length of the genes and not to the specific genes involved or the function of those genes,” says co-author Ander Izeta of the Biogipuzkoa Health Research Institute and Donostia University Hospital, Spain. It essentially comes down to chance; long genes simply have more potential sites that could be damaged. The researchers compare it to a road trip—the longer the trip, the more likely that something will go wrong. And because some cell types tend to express long genes more than others, these cells are more likely to accumulate DNA damage as they age. Cells that don’t (or very rarely) divide also seem to be more susceptible compared to rapidly replicating cells because long-lived cells have more time to accumulate DNA damage and must rely on DNA repair mechanisms to fix them, whereas rapidly dividing cells tend to be short-lived. Link to Neurodegeneration Because neural cells are known to express particularly long genes and are also slow or non-dividing, they are especially susceptible to the phenomenon, and the researchers highlight the link between aging and neurodegeneration. Many of the genes involved in preventing protein aggregation in Alzheimer’s disease are exceptionally long, and pediatric cancer patients, who are cured by DNA-damaging chemotherapy, later suffer from premature aging and neurodegeneration. The authors speculate that damage to long genes could explain most of the features of aging because it is associated with known aging accelerants and because it can be mitigated with known anti-aging therapies, such as dietary restriction (which has been shown to limit DNA damage). “Many different things that are known to affect aging seem to lead to this length-dependent regulation, for example, different types of irradiation, smoking, alcohol, diet, and oxidative stress,” says co-author Thomas Stoeger of Northwestern University. However, although the association between the decline in long-gene expression and aging is strong, causative evidence remains to be demonstrated. “Of course, you never know which came first, the egg or the chicken, but we can see a strong relationship between this phenomenon and many of the well-known hallmarks of aging,” says Izeta. In future studies, the researchers plan to further investigate the phenomenon’s mechanism and evolutionary implications and to explore its relationship with neurodegeneration. Reference: “Time is ticking faster for long genes in aging” by Sourena Soheili-Nezhad, Olga Ibáñez-Solé, Ander Izeta, Jan H.J. Hoeijmakers and Thomas Stoeger, 21 March 2024, Trends in Genetics. DOI: 10.1016/j.tig.2024.01.009 This research was supported by the Max Planck Society, the Netherlands Organization for Scientific Research, the European Research Council, and the NIH. The START technology at the Salk Institute combines rabies virus tracing and transcriptomics to precisely map brain neuron connections, particularly identifying unique patterns among inhibitory neuron subtypes, which could revolutionize the development of targeted neurological treatments. Credit: SciTechDaily.com Salk Institute’s START technology maps brain connections with unrivaled precision, revealing unique patterns in inhibitory neuron subtypes, aiding the development of targeted neurological treatments. Researchers at the Salk Institute have developed a new brain-mapping neurotechnology that combines two advanced technologies— monosynaptic rabies virus tracing and single-cell transcriptomics— to map the brain’s intricate neuronal connections with unprecedented precision. Using this technique, called Single Transcriptome Assisted Rabies Tracing (START), the researchers became the first to identify the patterns of connectivity made by transcriptomic subtypes of inhibitory neurons in the cerebral cortex. They say having this ability to map the connectivity of neuronal subtypes will drive the development of novel therapeutics that can target certain neurons and circuits with greater specificity. Such treatments could be more effective and produce fewer side effects than current pharmacological approaches. A cortical neuron labeled with monosynaptic rabies virus (orange). Credit: Salk Institute Breakthrough in Brain Mapping The study, published on September 30 in Neuron, is the first to resolve cortical connectivity at the resolution of transcriptomic cell types. “When it comes to treating neurological and neuropsychiatric disorders, we’ve essentially been trying to fix a machine without fully understanding its parts,” says senior author Edward Callaway, professor and Vincent J. Coates Chair in Molecular Neurobiology at Salk. “START is helping us create a detailed blueprint of the brain’s many parts and how they all connect.” It’s like trying to repair a car without knowing what an engine or an axle is, he says. But if you had a diagram of the car’s parts, you could start to understand how they might work together to make the wheels spin and the car move. That knowledge would then make it much easier to spot a problem in the system and figure out which tools you’ll need to fix it. An example Sst Chordl cell (left) shows dense projections to cortical layer 6, while another inhibitory subtype, Sst Hpse Cbln4 (right), shows dense projections to layer 4. Credit: Salk Institute Neuronal Classification and Connectivity When describing a brain’s parts, neurons are initially grouped into two broad classes: excitatory (those that stimulate brain activity) and inhibitory (those that suppress activity)—similar to the accelerator and brake in a car. From there they can be further sorted into subclasses: Excitatory neurons are categorized by the layer of the brain they’re in while inhibitory neurons are identified by the marker proteins they express. Recent advances in transcriptomics now allow these subclasses to be broken down even further. Using single-cell RNA sequencing, scientists can now group cells with similar gene expression patterns and define each cluster as a specific neuronal subtype. “Defining a cell type is complicated because you might group cells differently depending on which method you’re using to look at them,” Callaway says. “Two cells can have slightly different gene expression patterns but perform a similar function, or two cells with similar gene expression could be further separated based on their anatomy, connectivity, or physiology. If you only consider one of those features, you could end up over-splitting or under-splitting the groups. START helps us understand what level of categorization may be most meaningful to circuit function, and that will inform which cells to target with new therapeutics.” Salk Professor Edward Callaway. Credit: Salk Institute Application and Future of START To create START, the Callaway lab engineered a way to combine single-cell RNA sequencing with another technique they had developed previously: monosynaptic rabies virus tracing. The approach lets a modified virus hop from one cell type of interest to only the cells directly connected to it. By detecting where the virus ends up, the researchers can map which cells are connected to which. The researchers first used their new tool to explore connectivity patterns in the mouse visual cortex. START was able to resolve around 50 different subtypes of inhibitory neurons in this region and map their connections to excitatory neurons in each layer of the cortex. The researchers’ findings identified distinct connectivity patterns across various transcriptomic subtypes of inhibitory neurons that could not have been distinguished using previous methods. “People often treat all inhibitory neurons as a single uniform group, but they’re actually very diverse, and trying to study or clinically target them as one group can obscure important differences that are critical to brain function and disease,” says first author Maribel Patiño, a former graduate student in Callaway’s lab and current psychiatry resident at UC San Diego School of Medicine. START revealed that each cortical layer of excitatory neurons received selective input from specific transcriptomic subtypes of Sst, Pvalb, Vip, and Lamp5 inhibitory cells. Each subtype’s unique connectivity helps establish sophisticated microcircuits that likely contribute to specialized brain functions. For example, the researchers were able to resolve an inhibitory subtype called Sst Chodl cells, which are thought to be associated with sleep regulation. Using START, they found that Chodl cells were the cell type most densely connected to layer 6 excitatory neurons, which are known to project to the thalamus to coordinate sleep rhythms. This unprecedented resolution will allow neuroscientists to continue uncovering how specific neuronal subtypes shape the brain’s circuitry to produce our thoughts, perceptions, emotions, and behaviors. The researchers’ next steps are to create viral vectors and gene-editing technologies that target each individual cell subtype. In the future, these tools could be adapted into novel therapeutics that selectively modify the specific neuron populations contributing to conditions such as autism, Rett syndrome, and schizophrenia. “We don’t know exactly how this information is going to be used 10 or 20 years from now, but what we do know is that technologies are changing rapidly, and the way the brain is treated today with drugs is not the way the brain will be treated in the future,” says Callaway. “START can help drive this innovation, so the viruses and resources are all freely available for the entire neuroscience community to use.” Reference: “Transcriptomic cell-type specificity of local cortical circuits” by Maribel Patiño, Marley A. Rossa, Willian Nuñez Lagos, Neelakshi S. Patne and Edward M. Callaway, 30 September 2024, Neuron. DOI: 10.1016/j.neuron.2024.09.003 The work was supported by the National Institutes of Health (R34 NS116885, T32 GM007198, P30 014195, S10 OD023689) and the Paul and Daisy Soros Fellowship for New Americans. RRG455KLJIEVEWWF |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 最新創作 |
|
||||
|
||||
|
||||
|
||||
|
||||
