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文章數：110 |
 印月餐廳整體體驗如何？》台中公益路吃什麼？這10家絕對不能錯過 |
| 興趣嗜好｜偶像追星 2026/04/21 11:06:30 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 一笈壽司服務態度如何？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。加分100%浜中特選昆布鍋物小資族值得嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。一笈壽司口味偏臺式還是日式？ 下一餐，不妨從這10家開始。茶六燒肉堂過年期間會開門嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。加分100%浜中特選昆布鍋物值得專程去嗎？ 如果你有私心愛店，也歡迎留言分享，一頭牛日式燒肉節慶時段會不會太難訂位？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。TANG Zhan 湯棧停車方便嗎？ Researchers analyze traditional seafood sustainability and greenhouse gas emissions to assess the “carbon footprint” of U.S. tuna fisheries. A new study published in Elementa by researchers at the University of California, Santa Cruz and NOAA examines traditional aspects of seafood sustainability alongside greenhouse gas emissions to better understand the “carbon footprint” of U.S. tuna fisheries. Fisheries in the United States are among the best managed in the world, thanks to ongoing efforts to fish selectively, end overfishing, and rebuild fish stocks. But climate change could bring dramatic changes in the marine environment that threaten seafood productivity and sustainability. That’s one reason why researchers set out to broaden the conversation about sustainability in seafood by comparing the carbon emissions of different tuna fishing practices. The paper also puts those emissions in context relative to other sources of protein, like tofu, chicken, pork, or beef. In particular, the study examined how the carbon footprint of tuna was affected by how far from shore fishing fleets operated, or what type of fishing gear they used. “This can be an opportunity to look at fisheries from different angles, all of which may be important,” said Brandi McKuin, the study’s lead author and a postdoctoral researcher in environmental studies at UC Santa Cruz. Comparing Carbon Footprints Generally speaking, less selective tuna fishing gear — like purse seine nets that scoop up many tuna all at once — are more likely to accidentally catch other species during the fishing process. That’s called bycatch, and it’s a conservation concern that often factors into seafood sustainability assessments. But selective gear targeted more specifically for tuna, like trolling lines that reel fish in one at a time, typically have a higher carbon footprint, according to the study’s estimates. That’s because fishing vessels using these methods had to travel greater distances or spend more time on the water to catch their allotment of fish, which meant they used more fuel. In one example, skipjack tuna had up to 12 times more estimated climate forcing when produced with trolling gear rather than purse seine gear. Skipjack from purse seine fleets had an estimated carbon footprint almost low enough to compete with plant-based protein sources, like tofu, but this style of fishing can have relatively high bycatch. On the other hand, skipjack produced from trolling has almost no bycatch, but the study estimates its carbon footprint falls on the higher end of the protein spectrum, between pork and beef. There were other fishing methods that seemed to strike a balance. Albacore tuna caught on trolling and pole-and-line fishing gear by the North Pacific surface methods fleet had both negligible bycatch and relatively low estimated climate impacts. Comparing bycatch, carbon footprints, and other environmental criteria can get complicated for seafood consumers, but overall, tuna had a relatively low estimated carbon footprint: less than or similar to that of chicken and lower than beef or pork, for most of the fishing methods studied. “Given recent headlines about how much carbon is unleashed by commercial fishing activities, it’s important to have a rigorous, peer-reviewed data analysis which demonstrates the carbon footprint of tuna fishing activities is favorably low compared to many land-based food protein production alternatives,” said Stephen Stohs, a coauthor of the study who is a research economist at NOAA Fisheries’ Southwest Fisheries Science Center. Advancing Seafood Sustainability The study says consumers could choose to eat seafood with negligible bycatch impacts but a higher climate impact less often, just as some people choose to eat beef less often due to its climate impact. But the fishing industry may also be able to innovate in ways that would continue improving seafood sustainability on multiple fronts. Seafood producers with lower carbon footprints can look for ways to further reduce their bycatch, while those with higher carbon footprints can work to improve their efficiency, whether in catching fish or using fuel. The study provides several policy recommendations to help fisheries reduce their carbon footprints. One idea discussed in the study is shifting fuel subsidies for fishing away from fossil fuels and toward investments in electrification technology and infrastructure, like hybrid electric and battery electric boat propulsion, as these options become more feasible. While this technology can’t yet support longer offshore trips, it already shows potential for coastal fleets. And support for electrification efforts could prioritize fleets using highly selective fishing gear. Another idea for lowering the carbon footprint of seafood is finding ways to offset emissions. But this strategy would first require a better understanding of emissions across the U.S. fishing sector. There are gaps in data about fuel use intensity for fishing vessels, which was a challenge even for the current study. But increased insight on emissions across the fishing sector could help with designing solutions. Some within the fishing industry are already taking up this challenge. For example, the pollock industry in Alaska is setting an example by conducting a life cycle assessment to take a full inventory of their carbon footprint. Efforts like these have the potential to yield new sustainability benefits, and Brandi McKuin hopes more seafood producers will follow suit. “Companies are asking themselves, ‘What is our carbon footprint?’ and that awareness can help them lead important change in the industry,” McKuin said. Reference: “Rethinking sustainability in seafood: Synergies and trade-offs between fisheries and climate change” by Brandi McKuin, Jordan T. Watson, Stephen Stohs and J. Elliott Campbell, 5 April 2021, Elementa: Sciences of the Anthropocene. DOI: 10.1525/elementa.2019.00081 By tracing the steps of liver regrowth, MIT engineers hope to harness the liver’s regenerative abilities to help treat chronic disease. Hepatocytes, the one pictured here, are the main functional cells of the liver. Credit: NIH Tissue Model Reveals Key Players in Liver Regeneration By tracing the steps of liver regrowth, MIT engineers are striving to harness the liver’s regenerative abilities to help treat chronic disease. The human liver has incredible regeneration capabilities: Even if up to 70% of it is removed, the remaining tissue can regrow a full-sized liver in just months. Being able to take advantage of this regenerative capability could provide doctors with a plethora of options for treating chronic liver disease. MIT engineers have now taken a step toward that goal, by creating a novel liver tissue model that allows them to more precisely trace the steps involved in liver regeneration than has been possible before. Using the new model can yield information that couldn’t be gleaned from studies of mice or other animals, whose biology is not identical to that of humans, says Sangeeta Bhatia, the leader of the research team. “For years, people have been identifying different genes that seem to be involved in mouse liver regeneration, and some of them seem to be important in humans, but they have never managed to figure out all of the cues to make human liver cells proliferate,” says Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and of Electrical Engineering and Computer Science at MIT and a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science. The new study, which appears this week in the Proceedings of the National Academy of Sciences, has identified one molecule that appears to play a key role, and also yielded several other candidates that the researchers plan to explore further. The lead author of the paper is Arnav Chhabra, a former MIT graduate student and postdoctoral researcher. Regeneration on a chip Most of the patients who need liver transplants suffer from chronic illnesses such as viral hepatitis, fatty liver disease, or cancer. However, if researchers had a reliable way to stimulate the liver to regenerate on its own, some transplants could be avoided, Bhatia says. Or, such stimulation might be used to help a donated liver grow after being transplanted. From studies in mice, researchers have learned a great deal about some of the regeneration pathways that are activated after liver injury or illness. One key factor is the reciprocal relationship between hepatocytes (the main type of cell found in the liver) and endothelial cells, which line the blood vessels. Hepatocytes produce factors that help blood vessels develop, and endothelial cells generate growth factors that help hepatocytes proliferate. Another contributor that researchers have identified is fluid flow in the blood vessels. In mice, an increase in blood flow can stimulate the endothelial cells to produce signals that promote regeneration. “Right now when patients come in with liver failure, you have to transplant them because you don’t know if they’re going to recover on their own. But if we knew who had a robust regenerative response, and if we just needed to stabilize them for a little while, we could spare those patients from transplant.” Sangeeta Bhatia To model all of these interactions, Bhatia’s lab teamed up with Christopher Chen, the William F. Warren Distinguished Professor of Biomedical Engineering at Boston University, who designs microfluidic devices with channels that mimic blood vessels. To create these models of “regeneration on a chip,” the researchers grew blood vessels along one of these microfluidic channels and then added multicellular spheroid aggregates derived from liver cells from human organ donors. The chip is designed so that molecules such as growth factors can flow between the blood vessels and the liver spheroids. This setup also allows the researchers to easily knock out genes of interest in a specific cell type and then see how it affects the overall system. Using this system, the researchers showed that increased fluid flow on its own did not stimulate hepatocytes to enter the cell division cycle. However, if they also delivered an inflammatory signal (the cytokine IL-1-beta), hepatocytes did enter the cell cycle. When that happened, the researchers were able to measure what other factors were being produced. Some were expected based on earlier mouse studies, but others had not been seen before in human cells, including a molecule called prostaglandin E2 (PGE2). The MIT team found high levels of this molecule, which is also involved in zebrafish regeneration, in their liver regeneration system. By knocking out the gene for PGE2 biosynthesis in endothelial cells, the researchers were able to show that those cells are the source of PGE2, and they also demonstrated that this molecule stimulates human liver cells to enter the cell cycle. Human-Specific Pathways The researchers now plan to further explore some of the other growth factors and molecules that are produced on their chip during liver regeneration. “We can look at the proteins that are being produced and ask, what else on this list has the same pattern as the other molecules that stimulate cell division, but is novel?” Bhatia says. “We think we can use this to discover new human-specific pathways.” In this study, the researchers focused on molecules that stimulate cells to enter cell division, but they now hope to follow the process further along and identify molecules needed to complete the cell cycle. They also hope to discover the signals that tell the liver when to stop regenerating. Bhatia hopes that eventually, researchers will be able to harness these molecules to help treat patients with liver failure. Another possibility is that doctors could use such factors as biomarkers to determine how likely it is that a patient’s liver will regrow on its own. “Right now when patients come in with liver failure, you have to transplant them because you don’t know if they’re going to recover on their own. But if we knew who had a robust regenerative response, and if we just needed to stabilize them for a little while, we could spare those patients from transplant,” Bhatia says. Reference: “A vascularized model of the human liver mimics regenerative responses” by Arnav Chhabra, H.-H. Greco Song, Katarzyna A. Grzelak, William J. Polacheck, Heather E. Fleming, Christopher S. Chen and Sangeeta N. Bhatia, 28 June 2022, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2115867119 The research was funded in part by the National Institutes of Health, the National Science Foundation Graduate Research Fellowship Program, Wellcome Leap, and the Paul and Daisy Soros Fellowship Program. An artistic representation of the antibiotics found in frogs. Credit: Jianing “Jenny” Bai Engineered frog-derived peptides may become powerful new antibiotics, showing strong results against resistant bacteria in early testing. Frogs have thrived for hundreds of millions of years, adapting to environments ranging from tropical rainforests to subarctic woodlands. Over the course of their evolution, they have developed a range of powerful defenses against the many bacteria that flourish in their damp habitats, including previously unreported antibiotic compounds. Variants of these natural antibiotics could one day help protect humans against drug-resistant pathogens. In a new paper in Trends in Biotechnology (Cell Press), Cesar de la Fuente, Presidential Associate Professor in Bioengineering and in Chemical and Biomolecular Engineering in the University of Pennsylvania School of Engineering and Applied Science (Penn Engineering), in Psychiatry and Microbiology in the Perelman School of Medicine (PSOM), and in Chemistry in the School of Arts & Sciences, describes the creation of synthetic peptides, a class of antibiotics, derived from the secretions of a frog commonly found in South Asia. Nature’s Antibiotic Toolkit The paper builds on previous work from de la Fuente’s lab, which has discovered novel antibiotics in a range of unlikely places: the DNA of extinct organisms, including the wooly mammoth; the DNA of Neanderthals; and the human gut microbiome. “Each study is motivated by imagining environments where evolution would spur the creation of antibiotics”, says de la Fuente. “Amphibians live in very microbe-rich environments. They very rarely get infected despite being surrounded by microbes, so they must produce antimicrobial compounds.” The lab of César de la Fuente has discovered a novel antibiotic in frog secretions. Credit: Kevin Monko In 2012, researchers in China discovered that Odorrana andersonii, a species of frog first described in the late 19th century by a Belgian naturalist and named for its distinctive odor, secretes a peptide with antimicrobial activity, dubbed Andersonnin-D1. However, that peptide tends to form clumps, increasing the likelihood of toxic side effects and diminishing its efficacy at fighting bacteria, making it unsuitable for clinical use. Improving Nature’s Molecules In the new paper, de la Fuente and his co-authors demonstrate how “structure-guided design,” a process involving minute changes to the peptide’s chemical structure, yields multiple antibiotic candidates without the drawbacks of the unmodified peptide. “With structure-guided design, we change the sequence of the molecule,” says Marcelo Torres, a research associate in the de la Fuente lab and co-author of the paper, “and then we see how those mutations affect the function that we are trying to improve.” Turning Peptides into Potential Therapies After going through two rounds of structure-guided design, the researchers then tested the resulting synthetic peptides against a range of bacteria. In preclinical models, the team found that the new compounds were as effective as last-resort antibiotics like polymyxin B in targeting harmful bacteria, without affecting human cells or beneficial gut bacteria. The researchers developed and tested their peptides not only in single cultures but also in more complex bacterial communities, which allowed them to measure the effects in a more realistic microbial setting. “Those experiments are very difficult to set up because you need to grow different bacteria at once,” says de la Fuente. “We had to come up with the specific ratio of each bacterium to have a sustained community.” If additional preclinical testing goes well, the researchers will submit the peptides for what are known as Investigational New Drug (IND) enabling studies, the last step prior to applying for approval from the U.S. Food and Drug Administration, at which point the drugs could be clinically tested. De la Fuente underscores nature’s profound potential in medical innovation. “We are excited that frogs — and nature in general — can inspire new molecules that could be developed into antibiotics,” he says. “Thanks to the power of engineering, we can take those natural molecules and turn them into something more useful for humanity.” Reference: “Frog-derived synthetic peptides display anti-infective activity against Gram-negative pathogens” by Lucía Ageitos, Andreia Boaro, Angela Cesaro, Marcelo D.T. Torres, Esther Broset and Cesar de la Fuente-Nunez, 25 March 2025, Trends in Biotechnology. DOI: 10.1016/j.tibtech.2025.02.007 This study was conducted at the University of Pennsylvania School of Engineering and Applied Science. Cesar de la Fuente-Nunez holds a Presidential Professorship at the University of Pennsylvania and acknowledges funding from the Procter & Gamble Company, United Therapeutics, a BBRF Young Investigator Grant, the Nemirovsky Prize, Penn Health-Tech Accelerator Award, Defense Threat Reduction Agency grants HDTRA11810041 and HDTRA1-23-1-0001, and the Dean’s Innovation Fund from the Perelman School of Medicine at the University of Pennsylvania. Research reported in this publication was supported by the Langer Prize (AIChE Foundation), the NIH R35GM138201, and DTRA HDTRA1-21-1-0014. RRG455KLJIEVEWWF |
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