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文章數：82 |
 一頭牛日式燒肉婚前派對適合嗎？》台中公益路美食Top10｜選店困難症救星 |
| 時事評論｜政治 2026/04/22 11:17:22 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 永心鳳茶大型聚餐空間夠不夠？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。永心鳳茶長官聚餐合適嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。茶六燒肉堂海鮮表現如何？ 下一餐，不妨從這10家開始。永心鳳茶有什麼推薦搭配？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。印月餐廳值得推薦嗎？ 如果你有私心愛店，也歡迎留言分享，KoDō 和牛燒肉家庭過節聚會適合嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。一笈壽司必點有哪些？ Akarotaxis gouldae, a newly discovered species of Antarctic dragonfish, was named in honor of the recently decommissioned Antarctic research supply vessel Laurence M. Gould. Credit: Andrew Corso Newly identified Antarctic dragonfish, Akarotaxis gouldae, displays unique traits and faces threats from climate change and fishing, underscoring conservation challenges. Researchers at William & Mary’s Virginia Institute of Marine Science (VIMS) have discovered a new species of Antarctic dragonfish in waters off the western Antarctic Peninsula. The species, named Akarotaxis gouldae or Banded Dragonfish, exemplifies both the unknown biodiversity and fragile state of the Antarctic ecosystem. Genetic Analysis and Species Identification Akarotaxis gouldae, described in the journal Zootaxa, was initially identified through genetic analysis. Larval specimens collected off the coast of Antarctica while trawling for zooplankton were originally thought to be Akarotaxis nudiceps, a closely related dragonfish. However, after comparing their DNA to Akarotaxis nudiceps specimens housed in collections at VIMS, Yale University and the Muséum national d’Histoire naturelle in Paris, France, significant variations in mitochondrial gene regions suggested the larval samples were a species unto themselves. Adult samples of Akarotaxis gouldae (left) compared to adult samples of Akarotaxis nudiceps (right) show subtle yet distinct morphological differences, including the presence of two bands on the bodies of Akarotaxis gouldae as well as a shorter snouts and jaws. Credit: Andrew Corso Significance of Morphological Examination Lead author Andrew Corso conducted the research while earning his Ph.D. at W&M’s Batten School of Coastal & Marine Sciences at VIMS under faculty advisors Eric Hilton and Deborah Steinberg. Using the DNA evidence as their guide, Corso and his colleagues requested the examination of adult Akarotaxis gouldae samples from numerous ichthyology collections around the world. Morphological differences became apparent between the two species once the adult samples were compared. “There are two distinct bands on the sides of adult Akarotaxis gouldae that are not present on Akarotaxis nudiceps, so we were surprised that the species already existed in collections but had been previously overlooked,” said Corso. “In the world of fish taxonomy, it’s becoming common to distinguish species with genetics alone. Genetic testing is an extremely valuable tool, but our discovery highlights the importance of early life stage morphology and natural history collections like those at VIMS and other institutions.” This map shows where larval samples of Akarotaxis gouldae (yellow arrows) were collected along the western Antarctic Peninsula. Compared to Akarotaxis nudiceps, Akarotaxis gouldae appear to have a much more limited range. Credit: Andrew Corso Evolutionary Insights from Genetic Studies Genetic testing also revealed evolutionary clues. Using a process called time-calibrated phylogeny, Corso and coauthor Thomas Desvignes from the Institute of Neuroscience at the University of Oregon estimated that Akarotaxis gouldae diverged as a separate species approximately 780,000 years ago. During this time, most of the Southern Ocean was covered in glaciers. “This process essentially looks at the rate of genetic mutations as a guide for a species’ evolutionary history,” said Corso. “We hypothesize that a population of dragonfishes may have become isolated within deep trenches under glaciers, surviving on food pushed in by the moving ice. Once the glaciers retreated, this subpopulation had become distinct enough to be reproductively incompatible with Akarotaxis nudiceps.” The ARSV Laurence M. Gould was retired from NSF operations in April. It was one of two research supply vessels supporting U.S. Antarctic research. Credit: Kharis Shrage Conservation Concerns for the Newly Discovered Species Presently, Antarctic dragonfishes are poorly understood because they live in the remote Southern Ocean and spend most of their adult lives in deep water. Prior research suggests these fishes engage in nest guarding in shallower coastal waters, and their offspring remain closer to the surface during their larval stage. Examination of female ovaries showed limited reproductive capacity. While Akarotaxis nudiceps are distributed in waters surrounding the southern continent, analysis of larval sampling data suggests the distribution of Akarotaxis gouldae is limited to the waters around the western Antarctic Peninsula. Dragonfishes are important prey items for many species, including Antarctica’s iconic penguins, whose populations have declined dramatically in recent decades. A 2022 study by Corso linked warming waters and reduced ice in the Southern Ocean to declines in Antarctic silverfish populations. “Akarotaxis gouldae appear to have one of the smallest ranges of any fish endemic to the Southern Ocean,” said Corso. “This limited range combined with their low reproductive capacity and the presence of early life stages in shallower waters suggest that this is a vulnerable species that could be impacted by the krill fishery.” The waters surrounding the western Antarctic Peninsula are heavily targeted by the international Antarctic krill fishery, which is managed by the Conservation of Antarctic Marine Living Resources (CCAMLR). Commercial fishing vessels trawl for krill in waters between 0-250 meters deep, and CCAMLR emphasizes the difficulties in correctly identifying larval and juvenile finfish bycatch in these operations. “Since we know so little about the biodiversity of this area, we feel caution should be taken in extracting resources until we have a better understanding of the impact to the greater ecosystem,” said Corso. Implications of the Discovery and Naming the New Species The ARSV Laurence M. Gould was named after Laurence McKinnley Gould, the chief scientist on the first expedition to Antarctica. While most might assume Akarotaxis gouldae was also named in honor of the famous geologist, the researchers rather decided to honor the vessel for its significant scientific contributions of it and its crew. Challenges and Future Directions in Antarctic Research The ARSV Laurence M. Gould supported the U.S. National Science Foundation’s Antarctic Program from 1997 until the non-renewal of its charter in April of this year. It was one of two U.S. ARSVs dedicated to studying the Southern Ocean. While a replacement vessel is in the design phase, the U.S. National Science Foundation explained the Gould’s charter was not renewed for economic reasons as well as shifting research priorities of the U.S. Antarctic Program. The ARSV Laurence M. Gould and its crew provided significant support to Antarctic research carried out by VIMS and other institutions. Corso’s advisor Steinberg conducts long-term studies focusing on the effects of climate change on zooplankton communities around the western Antarctic Peninsula and their impact on the marine food web. Such research relies on regular sampling intervals, which must be adjusted based on the availability of support vessels like the Gould. “To me, the loss of the ARSV Laurence M. Gould marks a setback in the scientific study of the Antarctic region,” said Corso. “Antarctica is warming faster than anywhere in the Southern Hemisphere, and there is untold biodiversity in the region that we’re only beginning to understand. By naming this fish after the ship, we hope to honor its scientific contributions while also bringing attention to the need for additional resources to study this unique ecosystem.” Reference: “Akarotaxis gouldae, a new species of Antarctic dragonfish (Notothenioidei: Bathydraconidae) from the western Antarctic Peninsula” by Andrew D. Corso, Thomas Desvignes, Jan R. McDowell, Chi-Hing Christina Cheng, Ellen E. Biesack, Deborah K. Steinberg and Eric J. Hilton, 30 August 2024, Zootaxa. DOI: 10.11646/zootaxa.5501.2.3 Bald eagles and other wildlife in the southern United States have been facing a mysterious neurodegenerative disease since the 1990s. New research links the cause to a toxin produced by cyanobacteria on invasive aquatic plants, potentially exacerbated by herbicides used to control these plants. Mysterious Eagle Deaths Traced to Toxin Bald eagles, as well as other wildlife, have been succumbing to a mysterious neurodegenerative disease in the southern United States since the 1990s. New research by the Martin Luther University Halle-Wittenberg (MLU) in Germany and the University of Georgia, USA, identifies the cause of these deaths: a toxin produced by cyanobacteria that grow on invasive aquatic plants. The problem is potentially exacerbated by herbicides used to control those plants. The results were published in Science. In 1994, bald eagles were dying on a mass scale in the U.S. state of Arkansas. The animals were losing control over their bodies, and holes were developing in their brains. A previously unknown neurodegenerative disease, termed vacuolar myelinopathy (VM), was identified. “The origin of the disease was a complete mystery,” says Professor Timo Niedermeyer from the Institute of Pharmacy at MLU. Link to Invasive Aquatic Plant and Cyanobacteria Later on, American researchers found that not only eagles were affected, but also their herbivorous prey. The scientists discovered a connection to an invasive aquatic plant (Hydrilla verticillata) that grows in freshwater lakes in the affected regions. However, there were still some lakes with the aquatic plant where the disease was not manifesting. In 2005 Susan B. Wilde, a professor at the Warnell School of Forestry and Natural Resources at the University of Georgia, identified a previously unknown cyanobacterium on the leaves of Hydrilla verticillata, which appeared to be the cause of the disease. It turned out that vacuolar myelinopathy only occurs in places where the cyanobacterium colonizes the invasive plant. She called the bacterium “eagle killer that grows on Hydrilla”: Aetokthonos hydrillicola. Bacterial colonies of the cyanobacterium A. hydrillicola growing on a leaf of the invasive aquatic plant H. verticillata. Credit: Susan Wilde “I stumbled across a press release issued by the university in Georgia and was fascinated by these findings, because I’ve worked with cyanobacteria for years,” says Niedermeyer. He had samples sent to him, cultivated the bacteria in the laboratory, and sent them back to the U.S. for further testing. But the tests came back negative: The bacteria from the lab did not induce the disease. “It’s not just the birds that were going crazy, we were too. We wanted to figure this out,” says Niedermeyer. Once again, he had colonized leaves sent to him. Steffen Breinlinger, a doctoral student in his research group, then used a new imaging mass spectrometer to investigate the composition on the surface of the plant’s leaf, molecule by molecule. He discovered a new substance that only occurs on the leaves where the cyanobacteria grow, but is not produced in the cultivated bacteria. Proof of the Toxin’s Role in Eagle Deaths His investigations into the chemical structure of the isolated molecule showed that it contains five bromine atoms. “The structure is really spectacular,” says Breinlinger. The properties are unusual for a molecule formed by bacteria. And they provide an explanation for why the toxin did not form under laboratory conditions. Standard culture media in which cyanobacteria grow do not contain bromide. “We then added bromide to our lab cultures, and — the bacteria started producing the toxin,” says Breinlinger. Wilde and her colleagues tested the isolated molecule in birds, and finally, after almost a decade of research in the Wilde and Niedermeyer labs, they had the proof: the molecule does trigger VM. According to the name of the bacterium, the researchers call their discovery aetokthonotoxin, “poison that kills the eagle.” “Finally, we did not only catch the murderer, but we also identified the weapon the bacteria use to kill those eagles,” says Wilde. Bald Eagle flying. A research group participating in the study from the Czech Academy of Sciences also found sections of DNA containing genetic information for the synthesis of the new molecule. Why the cyanobacteria form the toxin on the aquatic plants in the first place, however, has yet to be studied. One of the herbicides used to combat the invasive aquatic plant might play a crucial part in VM occurrence: It contains bromide and thus might stimulate toxin production. The neurological disease has not yet occurred in Europe, and no instance of the toxin-forming cyanobacterium has been reported. Reference: “Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy” by Steffen Breinlinger, Tabitha J. Phillips, Brigette N. Haram, Jan Mare, José A. Martínez Yerena, Pavel Hrouzek, Roman Sobotka, W. Matthew Henderson, Peter Schmieder, Susan M. Williams, James D. Lauderdale, H. Dayton Wilde, Wesley Gerrin, Andreja Kust, John W. Washington, Christoph Wagner, Benedikt Geier, Manuel Liebeke, Heike Enke, Timo H. J. Niedermeyer and Susan B. Wilde, 26 March 2021, Science. DOI: 10.1126/science.aax9050 The research has been supported by the Deutsche Forschungsgemeinschaft (German Research Foundation, DFG), the Czech Science Foundation GACR, the US Department of Interior, US Fish and Wildlife Service, the Florida Fish & Wildlife Conservation Commission, the Gulf States Marine Fisheries Commission, the National Institute of Food and Agriculture McIntire-Stennis Capacity Grant and the American Eagle Foundation. This microscopy image shows a white blood cell creating a protrusion to reach out to a foreign body. Credit: Virginie Bazin, Claire Hivroz, Julien Husson Like a well-trained soldier, a white blood cell uses specialized abilities to identify and ultimately destroy dangerous intruders, including creating a protrusion to effectively reach out, lock-on, probe, and possibly attack its prey. Researchers reporting in the Biophysical Journal show in detail that these cells take seconds to morph into these highly rigid and viscous defensive units. Senior author Julien Husson, a biophysicist at École Polytechnique near Paris, and collaborators showed previously that certain white blood cells, called T cells, can push and pull perceived threats via specialized connections. To exert such forces, a cell must reorganize its internal structure, making itself more rigid. In the current study, Husson’s team devised a micropipette rheometer to measure the rigidity, along with the viscosity, of a white blood cell during its transformation. The researchers’ goal was to quantify the physical changes that arise in a white blood cell as it pushes or pulls on a foreign body — in this case, a bead coated with chemicals to attract the cell. These videos show a white blood cell creating a protrusion to reach out to a foreign body. Credit: Julien Husson, LadHyX, CNRS, École Polytechnique, Institut Polytec “We knew that when forming and using its protrusion, the cell was strongly reorganizing its cytoskeleton and that this cytoskeleton is a big player in giving a cell its mechanical properties,” says Husson. “So, I believed there should be some signature mechanical trace.” Stiffness is a measure of how much a material deforms when under a certain amount of pressure, whereas viscosity refers to how fast the material deforms under this pressure. Therefore, to simultaneously measure these properties of a white blood cell while instigating the cell’s immune response, the team needed an experimental setup that could somehow both maintain and vary the force on the cell while also causing it to respond as if it come upon a threat. This model shows a white blood cell creating a protrusion to reach out to a foreign body. Credit: Julien Husson The researchers’ solution was to apply a force that carefully oscillated around a constant, average value. The cell’s stiffness was calculated from the tiny deformation induced by the oscillations, and the viscosity was calculated from the delay between an oscillation and resulting deformation. At the same time, the object applying the force was a bead coated with antibodies, which caused the cell to activate, change shape, and latch onto the bead. “Despite expecting some mechanical changes, what we found was surprisingly dramatic,” says Husson. The team looked at three types of white blood cells and discovered that in all cases, “the cells’ stiffnesses and viscosities begin changing within seconds of coming into contact with the beads and increase up to ten times within minutes.” “Intriguingly,” Husson says, “the mechanical changes begin even before any shape changes,” evoking the question of whether these significant changes to white blood cells’ mechanical properties are simply consequences of other functions or have their own utility. The answer to this question could lie in another result of the study: Husson and colleagues found that a cell’s stiffness and viscosity change together, at a fixed ratio that is unique to the cell type, like a mechanical fingerprint. “It was really exciting to know that there was this kind of universality,” he says. Altogether, the paper’s results suggest an underlying physical mechanism that could apply broadly across cell types and lead to new models, theories, and ultimately a better understanding and control of our cells, in our immune system and beyond. Reference: “Rapid viscoelastic changes are a hallmark of early leukocyte activation” by Alexandra Zak, Sara Violeta Merino-Cortés, Anaïs Sadoun, Farah Mustapha, Avin Babataheri, Stéphanie Dogniaux, Sophie Dupré-Crochet, Elodie Hudik, Hai-Tao He, Abdul I. Barakat, Yolanda R. Carrasco and Yannick Ha, 4 May 2021, Biophysical Journal. DOI: 10.1016/j.bpj.2021.02.042 This work was primarily funded by the French National Research Agency, CNRS, École Polytechnique, and the AXA Research Fund. RRG455KLJIEVEWWF |
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