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文章數：87 |
 KoDō 和牛燒肉值得排隊嗎？》台中公益路高人氣餐廳推薦｜10家好吃又好拍 |
| 時事評論｜政治 2026/04/22 02:02:50 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 加分100%浜中特選昆布鍋物人潮很多嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。印月餐廳尾牙氣氛熱鬧嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。印月餐廳有什麼推薦搭配？ 下一餐，不妨從這10家開始。茶六燒肉堂春酒場面夠體面嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。永心鳳茶春酒菜色豐富嗎？ 如果你有私心愛店，也歡迎留言分享，一頭牛日式燒肉需要訂位嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。NINI 尼尼臺中店好吃嗎？ New findings on the Great Barrier Reef show varied heat tolerance in corals, suggesting potential for genetic conservation. This research could help develop more resilient coral populations through targeted breeding and restoration initiatives. Southern Cross University’s research revealed significant variations in heat tolerance among corals on the Great Barrier Reef, a discovery that could improve restoration and adaptation efforts. By studying over 500 coral colonies, scientists identified genetic and environmental factors influencing these variations, with implications for future coral resilience and conservation strategies. Previously undocumented variation in coral heat tolerance on Australia’s Great Barrier Reef has been discovered by researchers from Southern Cross University. Their findings give hope that corals’ own genetic resources may hold the key for us to help in their recovery and adaptation. In a study to be published today (September 23, 2024) in the journal Communications Earth and Environment, researchers measured the bleaching thresholds of more than 500 colonies of the table coral, Acropora hyacinthus, using a portable experimental system that was used at sea at 17 reefs spanning the Great Barrier Reef. The study was led by Southern Cross University PhD candidate Melissa Naugle, with a team from Southern Cross University, the Australian Institute of Marine Science (AIMS), the University of Queensland, and the Research Institute for Development in New Caledonia as part of the Reef Restoration and Adaptation Program (RRAP). Various degrees of bleaching in corals next to each other at Lizard Island on Great Barrier Reef. Credit Melissa Naugle Genetic Resources for Coral Protection “We found heat-tolerant corals at almost all the reefs that we studied, highlighting how corals across the entire Great Barrier Reef may hold genetic resources that are important for protection and restoration,” said Melissa. “This is important news for corals, which are experiencing the 4th global mass bleaching event and unprecedented summer sea temperatures on the Great Barrier Reef. Naturally occurring heat tolerance variation is crucial for corals to adapt to climate warming and for the success of restoration initiatives.” These findings were substantiated in another recent study by co-author and fellow Southern Cross University PhD candidate Hugo Denis, who also found widespread variation in heat tolerance in a different coral species. Experimental system used to test bleaching thresholds of over 500 coral colonies while at sea. Credit AIMS Joanna Hurford Implications for Coral Reef Futures The results of this work have important implications for coral reef futures. “Differences between individual corals is the fuel for natural selection to produce future generations of more tolerant corals,” said Dr. Line Bay, co-author and Senior Principal Research Scientist and Research Program Director at AIMS. “Developing a solid understanding of this variation is crucial to understanding how corals will adapt to climate warming.” Targeted Conservation Efforts Dr. Cedric Robillot, Executive Director of the Reef Restoration and Adaptation Program, said: “This work highlights the availability of naturally heat-tolerant corals that can be targeted by RRAP, as a large-scale reef restoration and conservation effort, to protect this critical ecosystem from warming ocean temperatures that are already locked in from climate change.” Dr. Emily Howells, co-author and Senior Research Fellow at Southern Cross University and Project Lead in the Reef Restoration and Adaptation Program, said: “Heat tolerance variation can be useful for restoration programs such as selective breeding, which may accelerate adaptation to produce offspring better suited to warmer waters. Though, this outcome depends on how much of the heat tolerance variation we observe is tied to heritable gene variants.” Selective Breeding and Restoration Programs The most heat-tolerant corals identified in this study are currently being used for a selective breeding trial through the Reef Restoration and Adaptation Program. The study reported not only the extent of the variation in coral heat tolerance, but also investigated the sources underlying that variation. “In this paper, we explored many of the environmental influences that shape heat tolerance, like thermal history, nutrient concentrations, and the symbiotic algae that live inside coral tissue,” said Melissa. Future Research and Implications While the study found that environmental factors like sea temperatures were important in influencing heat tolerance, there was substantial heat tolerance variation that could not be explained by the environment and is likely due to genetic differences among individual corals. “Next, we’ll analyze DNA-sequencing data from these individuals to identify gene variants associated with heat tolerance. This can help us understand the adaptation potential of natural coral populations and inform selective breeding work,” Melissa said. “While restoration initiatives like selective breeding may strengthen coral populations, reducing greenhouse gas emissions is most crucial to give coral reefs the best future possible.” Reference: “Heat tolerance varies considerably within a reef-building coral species on the Great Barrier Reef” by Melissa S. Naugle, Hugo Denis, Véronique J. L. Mocellin, Patrick W. Laffy, Iva Popovic, Line K. Bay and Emily J. Howells, 23 September 2024, Communications Earth & Environment. DOI: 10.1038/s43247-024-01649-4 Kyushu University researchers introduced QDyeFinder, an AI tool that enhances neuron mapping in the brain by using advanced color-coding and machine-learning, showing potential for broader applications in biology. Researchers have developed QDyeFinder, an AI pipeline that can untangle and reconstruct the dense neuronal networks of the brain. The brain is the most complex organ ever created. Its functions are supported by a network of tens of billions of densely packed neurons, with trillions of connections exchanging information and performing calculations. Trying to understand the complexity of the brain can be dizzying. Nevertheless, if we ever hope to understand how the brain works, we need to be able to map neurons and study how they are wired. Now, publishing in Nature Communications, researchers from Kyushu University have developed a new AI tool, which they call QDyeFinder, that can automatically identify and reconstruct individual neurons from images of the mouse brain. The process involves tagging neurons with a super-multicolor labeling protocol, and then letting the AI automatically identify the neuron’s structure by matching similar color combinations. Credit: Kyushu University/Takeshi Imai Challenges in Neuron Mapping “One of the biggest challenges in neuroscience is trying to map the brain and its connections. However, because neurons are so densely packed, it’s very difficult and time-consuming to distinguish neurons with their axons and dendrites—the extensions that send and receive information from other neurons—from each other,” explains Professor Takeshi Imai of the Graduate School of Medical Sciences, who led the study. “To put it into perspective axons and dendrites are only about a micrometer thick, that’s 100 times thinner than a standard strand of human hair, and the space between them is smaller.” One strategy for identifying neurons is to tag the cell with a fluorescent protein of a specific color. Researchers could then trace that color and reconstruct the neuron and its axons. By expanding the range of colors, more neurons could be traced at once. In 2018, Imai and his team developed Tetbow, a system that could brightly color neurons with the three primary colors of light. Mouse cortical layer 2/3 pyramidal neurons were labeled with 7-color Tetbow. A combination of 7 fluorescent proteins (mTagBFP2, mTurquoise2, mAmetrine1.1, mNeonGreen, Ypet, mRuby3, tdKatushka2) was used to visualize the dense wiring of neurons. The 7-channel images were then analyzed by the QDyeFinder program to reveal the wiring patterns of individual neurons. Credit: Kyushu University/Takeshi Imai “An example I like to use is the map of the Tokyo subway lines. The system spans 13 lines, 286 stations, and across over 300 km. On the subway map each line is color-coded, so you can easily identify which stations are connected,” explains Marcus N. Leiwe one of the first authors of the paper and Assistant Professor at the time. “Tetbow made tracing neurons and finding their connections much easier.” However, two major issues remained. Neurons still had to be meticulously traced by hand, and using only three colors was not enough to decern a larger population of neurons. Technological Breakthroughs with QDyeFinder The team worked to scale up the number of colors from three to seven, but the bigger problem then was the limits of human color perception. Look closely at any TV screen and you will see that the pixels are made up of three colors: blue, green, and red. Any color we can perceive is a combination of those three colors, as we have blue, green, and red sensors in our eyes. “Machines on the other hand don’t have such limitations. Therefore, we worked on developing a tool that could automatically distinguish these vast color combinations,” continues Leiwe. “We also made it so that this tool will automatically stitch together neurons and axons of the same color and reconstruct their structure. We called this system QDyeFinder.” QDyeFinder works by first automatically identifying fragments of axons and dendrites in a given sample. It then identifies the color information of each fragment. Then, utilizing a machine-learning algorithm the team developed called dCrawler, the color information was grouped together, wherein it would identify axons and dendrites of the same neuron. “When we compared QDyeFinder’s results to data from manually traced neurons they had about the same accuracy,” Leiwe explains. “Even compared to existing tracing software that makes full use of machine learning, QDyeFinder was able to identify axons with a much higher accuracy.” The team hopes that their new tool can advance the ongoing quest to map the connections of the brain. They would also like to see if their new method can be applied to the labeling and tracking of other complicated cell types such as cancer cells and immune cells. “There may come a day when we can read the connections in the brain and understand what they mean or represent for that person. I doubt it will happen in my lifetime, but our work represents a tangible step forward in understanding perhaps the most complicated and mysterious dimension of our existence,” concludes Imai. Reference: “Automated neuronal reconstruction with super-multicolour Tetbow labelling and threshold-based clustering of colour hues” by Marcus N. Leiwe, Satoshi Fujimoto, Toshikazu Baba, Daichi Moriyasu, Biswanath Saha, Richi Sakaguchi, Shigenori Inagaki and Takeshi Imai, 25 June 2024, Nature Communications. DOI: 10.1038/s41467-024-49455-y Funding: Japan Agency for Medical Research and Development, Japan Science and Technology Agency, Japan Society for the Promotion of Science, Uehara Memorial Foundation, Sumitomo Foundation, Ichiro Kanahara foundation, Daiichi Sankyo Foundation of Life Science, Brain Science Foundation CST (purple/lavender) bound to POT1 (red). Phosphorylation of the crimson-highlighted region in POT1 regulates the recruitment and activity of CST–Polα-primase at telomeres. Credit: Laboratory of Cell Biology and Genetics at The Rockefeller University Recent discoveries in telomere biology reveal that the length and health of chromosome ends are regulated by enzymes telomerase and CST–Polα/primase, coordinated by the protein POT1, highlighting implications for treating telomere disorders and cancer. The length of telomeres, which protect the ends of our chromosomes, must be carefully regulated. If they are too long, there is an increased risk of cancer; if they are too short, they lose their protective function, leading to telomere disorders that can have severe health implications. Our cells prevent this excessive shortening by adding telomeric DNA to the ends of chromosomes. Researchers at Rockefeller recently showed that this process is mediated by two enzymes: telomerase and the CST–Polα/primase complex. Having determined how telomerase is recruited, scientists were left with a fundamental question: how does CST–Polα/primase find its way to the telomere? Now, a new study published in Cell demonstrates that CST is recruited to the end of the telomere and regulated by subtle chemical changes made to POT1, a protein in the shelterin complex involved in telomere maintenance and implicated in cancer risk. The findings provide new insight into how human telomeres function at the molecular level, with implications for numerous diseases and disorders. “After the discovery of telomerase, it took decades to figure out how it gets to the telomere. Now, just months after discovering that CST–Polα/primase is the second critical enzyme required for telomere maintenance, we understand the details of how it is recruited,” says Titia de Lange, the Leon Hess professor. “Moreover, we’ve found out how this process is regulated.” Recruiting and regulating CST Telomeres have two different types of strands, G-rich and C-rich. Scientists have long known how telomerase maintains the length of the G-rich strand, but only recently was it recognized that the same problem also exists for the C-rich strand. A recent study from the de Lange lab identified the CST–Polα/primase complex as the key regulator responsible for keeping that strand intact. What remained to be seen was how CST, and its associated enzyme Polα-primase, travels to telomere to facilitate C-strand maintenance across replication cycles. Sarah Cai, a PhD candidate at Rockefeller, began investigating this piece of the telomere puzzle. Building on a decade of the de Lange lab’s groundwork on CST, Cai added cryo-EM to the techniques used in this study while being co-advised by Rockefeller’s Thomas Walz. “The interdisciplinary nature of the study is one of the most exciting parts,” Cai says. “It was a very successful double-lab effort, making use of many different technologies.” Walz, whose research focuses on cryo-EM, noted how Cai incorporated AlphaFold, a deep-learning algorithm that can predict the unique 3D structures of proteins, into her work. With the combined power of biochemistry, structural biology, and cell biology, the team ultimately confirmed that CST is recruited to telomeres by the POT1 protein. Once CST–Polα/primase is onsite, the addition and removal of phosphate groups from POT1 appears to function as an on/off switch that coordinates the final steps of telomere replication. Phosphorylated POT1 ensures that CST–Polα/primase remains inactive until telomerase has finished its job, upon which the dephosphorylation of POT1 activates CST–Polα/primase to add the finishing touches to the telomere. Telomere disorders and cancer Next, the team will look for specific enzymes that attach and remove phosphates during this process, controlling the on/off switch on POT1, and determining their role in regulating CST–Polα/primase recruitment and activity. A better understanding of how CST is recruited to the telomere cannot come fast enough for patients suffering from telomere disorders, such as Coats plus syndrome, a severe multi-organ disease characterized by abnormalities in the eyes, brain, bones, and GI tract. “For a long time, we didn’t know why mild alterations in single amino acids would cause such a devastating disease,” Cai says. “We now have a better idea of how these mutations affect the recruitment of this critical telomere maintenance machine and lead to Coats plus syndrome.” The findings will also impact their cancer research. The de Lange lab has spent decades studying how telomere shortening contributes to tumor suppression and genome instability in cancer, and the present research may ultimately help answer questions that lie at the heart of tumor development. “Anything critical to telomere length regulation may well be critical to cancer prevention too,” de Lange says. “This is a major focus of our lab, and one of the reasons we’ll be looking into the interplay between CST–Polα/primase and telomerase more closely in the future.” Reference: “POT1 recruits and regulates CST-Polα/primase at human telomeres” by Sarah W. Cai, Hiroyuki Takai, Arthur J. Zaug, Teague C. Dilgen, Thomas R. Cech, Thomas Walz and Titia de Lange, 4 June 2024, Cell. DOI: 10.1016/j.cell.2024.05.002 RRG455KLJIEVEWWF |
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