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文章數：98 |
 TANG Zhan 湯棧小資族值得嗎？》台中公益路食記攻略｜10家餐廳評分&推薦 |
| 知識學習｜考試升學 2026/04/21 18:45:33 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 茶六燒肉堂單點比較好嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。KoDō 和牛燒肉用餐環境舒服嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。NINI 尼尼臺中店肉質如何？ 下一餐，不妨從這10家開始。加分100%浜中特選昆布鍋物真的有那麼好吃嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。TANG Zhan 湯棧尾牙氣氛熱鬧嗎？ 如果你有私心愛店，也歡迎留言分享，加分100%浜中特選昆布鍋物價格合理嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。TANG Zhan 湯棧有什麼推薦搭配？ Long-term running substantially modifies the network of the neurons generated in young adult mice upon middle-age. Importantly, exercise increases input from hippocampal interneurons (red cells) onto ‘old’ adult-born neurons. These interneurons may play a role in reducing aging-related hyperexcitability of the hippocampus and thereby benefit memory function. Credit: Carmen Vivar, Ph.D. A new study reveals how exercise helps maintain memory function during aging. Aging is often linked with a decrease in cognitive functions. The hippocampus and neighboring cortices, which are crucial for learning and memory, are among the initial parts of the brain to be affected. Cognitive performance deficits correlate with a diminished hippocampal volume and deteriorated synaptic connectivity between the hippocampus and the (peri)-entorhinal cortex. Increasing evidence suggests that physical activity can help delay or avert these structural and functional diminutions in older individuals. A recent study conducted by Florida Atlantic University and CINVESTAV, Mexico City, Mexico, offers new insight into the benefits of exercise. This underscores the importance for adults, particularly those in middle age, to maintain physical activity throughout their lives. For the study, researchers focused on the effects of long-term running on a network of new hippocampal neurons that were generated in young adult mice, at middle age. These “mice on the run” demonstrate that running throughout middle age keeps old adult-born neurons wired, which may prevent or delay aging-related memory loss and neurodegeneration. Adult-born neurons are thought to contribute to hippocampus-dependent memory function and are believed to be temporarily important, during the so-called ‘critical period’ at about three to six weeks of cell age, when they can fleetingly display increased synaptic plasticity. However, these new neurons do remain present for many months, but it was unclear whether those born in early adulthood remain integrated into neural networks and whether their circuitry is modifiable by physical activity in middle age. To address these questions, researchers used a unique rabies virus-based circuit tracing approach with a long time interval between the initial labeling of new neurons and subsequent analysis of their neural circuitry in rodents. More than six months after tagging of the adult-born neurons with a fluorescent reporter vector, they identified and quantified the direct afferent inputs to these adult-born neurons within the hippocampus and (sub)cortical areas, when the mice were middle-aged. Results of the study, published in the journal eNeuro, show long-term running wires ‘old’ new neurons, born during early adulthood, into a network that is relevant to the maintenance of episodic memory encoding during aging. “Long-term exercise profoundly benefits the aging brain and may prevent aging-related memory function decline by increasing the survival and modifying the network of the adult-born neurons born during early adulthood, and thereby facilitating their participation in cognitive processes,” said Henriette van Praag, Ph.D., corresponding author, an associate professor of biomedical science in FAU’s Schmidt College of Medicine and a member of the FAU Stiles-Nicholson Brain Institute. Findings from the study showed long-term running significantly increased the number of adult-born neurons and enhanced the recruitment of presynaptic (sub)-cortical cells to their network. “Long-term running may enhance pattern separation ability, our ability to distinguish between highly similar events and stimuli, a behavior closely linked to adult neurogenesis, which is among the first to display deficits indicative of age-related memory decline,” said Carmen Vivar, Ph.D., corresponding author, Department of Physiology, Biophysics and Neuroscience, Centro de Investigacion y de Estudios Avanzados del IPN in Mexico. Aging-related memory function decline is associated with the degradation of synaptic inputs from the perirhinal and entorhinal cortex onto the hippocampus, brain areas that are essential for pattern separation, and contextual and spatial memory. “We show that running also substantially increases the back-projection from the dorsal subiculum onto old adult-born granule cells,” said van Praag. “This connectivity may provide navigation-associated information and mediate the long-term running-induced improvement in spatial memory function.” Results from the study show that running not only rescued perirhinal connectivity but also increased and altered the contribution of the entorhinal cortices to the network of old adult-born neurons. “Our study provides insight as to how chronic exercise, beginning in young adulthood and continuing throughout middle age, helps maintain memory function during aging, emphasizing the relevance of including exercise in our daily lives,” said Vivar. Reference: “Running throughout Middle-Age Keeps Old Adult-Born Neurons Wired” by Carmen Vivar, Ben Peterson, Alejandro Pinto, Emma Janke and Henriette van Praag, 15 May 2023, eNeuro. DOI: 10.1523/ENEURO.0084-23.2023 Study co-authors are Ben Peterson, Ph.D., currently a postdoc at UC Davis; Alejandro Pinto, FAU’s Schmidt College of Medicine and Stiles-Nicholson Brain Institute; and Emma Janke, a recent graduate of the University of Pennsylvania. This research was supported in part by the FAU Stiles-Nicholson Brain Institute and the Jupiter Life Sciences Initiative (awarded to van Praag), and by the Fondo de Investigación Científica y Desarrollo Tecnológico del Cinvestav (Proyectos SEP-Cinvestav), (awarded to Vivar). New research finds that continuous artificial light harms honey bees by disrupting their sleep patterns and circadian rhythms, thereby threatening their role in pollination and ecosystem health. Researchers at UC San Diego discovered that artificial light significantly disrupts the circadian rhythms of honey bees, which affects their health and essential pollination activities. Honey bees, key to ecosystem stability and global food security, experience reduced sleep and impaired behaviors under constant light. This study highlights the broader implications of light pollution on pollinator health and the urgency to develop protective strategies. Digital Devices and Sleep Disruption Sleep experts warn that using screens in bed can interfere with our sleep, as light from phones and other devices disrupts our natural sleep patterns. This finding is part of a broader understanding of how light affects our circadian biology and the crucial balance of our sleep-wake cycles. Researchers at the University of California San Diego have discovered that light disruption affects more than just human health. In a new study led by PhD candidate Ashley Kim and Professor James Nieh, artificial light was found to disrupt the circadian rhythms of honey bees, posing a significant threat to their role as vital pollinators. The prevalence of light pollution on sleeping honey bees varies from region to region. Credit: Ashley Kim, Nieh Lab, UC San Diego Impact of Light on Honey Bee Health “Our research shows just how sensitive honey bees are to changes in their environment, particularly to something as seemingly benign as artificial light,” said Kim of the study, published today (November 12) in Scientific Reports. “By disrupting their circadian rhythms, we see clear evidence of reduced sleep periods. This raises significant concerns, not only for bee health but also for the health of ecosystems that depend on them for pollination.” Honey bees play a crucial role as pollinators of wild plants and important crops, providing services that support ecosystem stability and global food security. Without pollination, crops worth tens of millions of dollars would be at risk. Honey bees generally prefer to nest in dark environments, although a small amount of light can enter from the hive entrance. Sleeping bees typically remain immobile but exhibit subtle movements if disturbed by nestmates. However, bees sleep outside when they swarm or when they form “bee beards” outside the nest on hot evenings, which are increasing under climate change. While the prevalence of artificial light at night (ALAN), or light pollution, on sleeping honey bees varies from region to region, modern urban environments are increasingly exposed to artificial light conditions, especially as temperatures rise. Because there has been a resurgence of urban beekeeping in many areas to support bees and their critical pollination services, bees that experience hotter weather are now potentially more exposed to ALAN. Researchers compared groups of bees that underwent normal sleep in the dark with others that were subjected to continuous artificial light. Credit: Ashley Kim, Nieh Lab, UC San Diego Bee Behavior Under Artificial Light Like us, when bees experience a poor night’s sleep and disrupted circadian patterns, problems in behavior and function emerge. Sleep is crucial for the health and fitness of honey bee colonies since they depend on an intricate system of communication known as the “waggle dance” that informs hive mates about the location of food sources in the environment. Bees dance more poorly and therefore do not communicate as well if they do not get enough sleep. Through a series of experiments spanning several years, the UC San Diego researchers compared groups of bees that underwent normal sleep in the dark with others that were subjected to continuous artificial light. The results clearly showed that prolonged exposure to light significantly disrupted the circadian rhythms of honey bees, leading to impaired behaviors. Since the bees were video recorded 24 hours a day during the experiments, Kim could immediately see the effects of disrupted sleep. Professor James Nieh and graduate student Ashley Kim. Credit: School of Biological Sciences, UC San Diego Addressing Light Pollution and Pollinator Health “Even without analyzing the data you can tell that there was something going on… the bees that were under constant light slept less,” said Kim. “The effects of light pollution on biological systems is fairly unknown and something people normally don’t think about, which is why it’s a rapidly evolving field.” Among the details described in the paper: Bees exposed to continuous light slept less and were more frequently disturbed by their peers compared to those kept in normal darkness. Also, bees under continuous light exhibited a preference for darker areas within their experimental cages. “Understanding the factors that affect bee health, such as light pollution, is essential for developing strategies to protect pollinator populations,” said Nieh. “Light pollution is a growing issue, with artificial light now covering a quarter of the Earth’s surface, and this research sheds new light on how such disturbances may be harming pollinators.” Two coauthors of the study, Aura Velazquez (Universidad La Salle México) and Belen Saavedra (Berea College), are undergraduate students who participated in the research as part of UC San Diego’s ENLACE initiative, a binational summer program in which students conduct research during a seven-week project. “I am pleased that the ENLACE summer research program was pivotal in providing research experiences for the student authors of this study,” said Olivia Graeve, the director of the ENLACE Program at UC San Diego and a professor in the Department of Mechanical and Aerospace Engineering, Jacobs School of Engineering. “By fostering collaboration between students from Latin America and the United States, we help young researchers gain valuable hands-on experience, building skills and friendships that extend across borders. This project exemplifies the impact of ENLACE, as it brings together diverse perspectives to address global challenges like pollinator health and environmental sustainability.” Nieh and study coauthor Benjamin Smarr, a faculty member in the Shu Chien-Gene Lay Department of Bioengineering, Jacobs School of Engineering, and Halıcıoğlu Data Science Institute, were recently awarded a related grant — which extends to human impacts — from the new Chancellor’s Interdisciplinary Team Catalyst Fund. “Harmonizing the Pulse of Life: Pioneering Circadian Insights for Human and Ecosystem Health at UC San Diego” furthers research on circadian biology and ecosystem health. The Nieh and Smarr labs will collaborate to examine circadian rhythms across scales, from individual bees to entire ecosystems. “The Catalyst Grant allows us to connect research on honey bee circadian rhythms to larger questions about biological synchronization across ecosystems and human health,” said Nieh. “This program fosters interdisciplinary collaboration, bringing together experts in biology, data science and medicine to address pressing issues like light pollution and its impact on pollinator health. Our work with the Catalyst Grant strengthens UC San Diego’s role in advancing solutions for both environmental sustainability and human well-being.” Reference: “Exposure to constant artificial light alters honey bee sleep rhythms and disrupts sleep” by Ashley Y. Kim, Aura Velazquez, Belen Saavedra, Benjamin Smarr and James C. Nieh, 12 November 2024, Scientific Reports. DOI: 10.1038/s41598-024-73378-9 Researchers have developed a new form of omega-3 fatty acid docosahexaenoic acid (DHA) that can cross into the eye’s retina, potentially helping to prevent visual decline linked to Alzheimer’s disease, diabetes, and other disorders. The newly created lysophospholipid form of DHA (LPC-DHA) was found to be more effective than the typical triacylglycerol (TAG) DHA in fish oil capsules, which cannot reach the eyes. In a study using mice, LPC-DHA increased DHA in the retina and reduced eye problems related to Alzheimer’s-like processes, suggesting a potential novel therapeutic approach for retinal dysfunction associated with Alzheimer’s disease and diabetes. By crossing into the retina, a new DHA supplement achieves what previous ones could not. For the first time, researchers have developed a form of the omega-3 fatty acid docosahexaenoic acid (DHA) that is capable of crossing into the eye’s retina to ward off visual declines related to Alzheimer’s disease, diabetes ,and other disorders. The DHA found in fish oil capsules and other supplements is typically in a form called triacylglycerol (TAG) DHA. Although TAG-DHA has benefits in other parts of the body, it does not reach the eyes because it cannot travel from the bloodstream into the retina. For the study, researchers created a new lysophospholipid form of DHA, or LPC-DHA. In studies using mice, LPC-DHA successfully increased DHA in the retina and reduced eye problems associated with Alzheimer’s-like processes. “Dietary LPC-DHA is enormously superior to TAG-DHA in enriching retinal DHA and could be potentially beneficial for various retinopathies in patients,” said Sugasini Dhavamani, a research assistant professor in the Department of Medicine at the University of Illinois at Chicago. “This approach provides a novel therapeutic approach for the prevention or mitigation of retinal dysfunction associated with Alzheimer’s disease and diabetes.” Sugasini Dhavamani, PhD, research assistant professor in the Department of Medicine at the University of Illinois at Chicago. Credit: Sugasini Dhavamani, University of Illinois at Chicago Dhavamani will present the research at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, March 25–28 in Seattle. In healthy eyes, DHA is concentrated in the retina, where it helps maintain photoreceptors, the cells that convert light into signals that are sent to the brain. DHA deficiency in the retina is associated with vision loss. People with Alzheimer’s disease, as well as those with diabetes, retinitis pigmentosa, age-related macular degeneration and peroxisomal disorders, frequently have abnormally low levels of retinal DHA, and visual impairments are common as a result. Challenges of Delivering DHA to the Retina While boosting DHA can help to prevent such declines, increasing retinal DHA content has been challenging with currently available supplements. For a dietary supplement to deliver DHA to the retina, the DHA must be able to first be absorbed from the intestine into the bloodstream and then cross from the bloodstream into the retina. “Increasing the retinal DHA at clinically feasible doses has not been possible until now because of the specificity of the blood-retinal barrier that is incompatible with the specificity of the intestinal barrier,” said Dhavamani. “This study uses the novel approach of dietary LPC-DHA that overcomes both intestinal and blood-retinal barriers and improves retinal function.” LPC-DHA Outperforms TAG-DHA The researchers tested their LPC-DHA supplement in mice bred to exhibit processes similar to those found in early-onset Alzheimer’s disease. After six months, mice that were fed LPC-DHA daily showed a 96% improvement in retinal DHA content as well as preserved retinal structure and function. In contrast, TAG-DHA supplements had no effect on retinal DHA levels or function. The results suggest that LPC-DHA supplements could help to prevent Alzheimer’s-related declines in visual function. Researchers say the approach should also be helpful for other disorders in which DHA deficiency and vision impairment are common. The dosage of LPC-DHA used in the study is equivalent to about 250 to 500 milligrams of omega-3 fatty acids per day in humans. Since these studies were conducted in mice, further studies would be needed to confirm that LPC-DHA is safe and effective for use in humans. Sugasini Dhavamani will present this research during the Spotlight Session on Chemical biology of natural products, nucleic acids and small molecules from 3:15–4:15 p.m. PDT on Monday, March 27, in Rooms 602–604 of the Seattle Convention Center. Contact the media team for more information or to obtain a free press pass to attend the meeting. This work was supported by an Alzheimer’s Association Research Grant (AARG). RRG455KLJIEVEWWF |
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