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文章數：96 |
 一頭牛日式燒肉適合多人分享嗎？》公益路餐廳推薦Top10｜吃貨實測大公開，這些店真的值得再訪嗎？ |
| 在地生活｜花東 2026/04/21 03:23:56 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： TANG Zhan 湯棧用餐時間會不會太短？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。三希樓年末聚餐推薦嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。KoDō 和牛燒肉調味偏重嗎？ 下一餐，不妨從這10家開始。NINI 尼尼臺中店春酒場面夠體面嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。一頭牛日式燒肉清淡口味適合嗎？ 如果你有私心愛店，也歡迎留言分享，KoDō 和牛燒肉包廂適合尾牙嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。永心鳳茶尾牙氣氛熱鬧嗎？ New research shows that sperm production is critical to how regions of the genome are re-organized within and between chromosomes during evolution. In particular, inherited chromosomal rearrangements are associated with physical and biochemical processes that are specific to the final stages of sperm production, after the meiotic cell divisions have completed. Researchers found that chromosomal rearrangements during sperm production play a key role in genome evolution, with male germ cells contributing more to these changes due to DNA compaction and repair processes. A study led by researchers at the Universitat Autònoma de Barcelona (UAB) and the University of Kent uncovers how the genome three-dimensional structure of male germ cells determines how genomes evolve over time. Published today (May 11, 2022) in Nature Communications and carried out in rodent species, these findings show that the distinctive events occurring during egg and sperm cell production have a different impact on genome evolution and open new research paths into the genetic origin of genome structure in all organisms. A comparison of genomes across many different mammalian species reveals that, while all species have a broadly similar catalog of genes, these are arranged in a different order for each species and can be turned off and on differently. These rearrangements may have an impact on gene function and regulation and, therefore, play a part in evolutionary changes and in defining species identity. Until now, the ultimate origin of these rearrangements has been a mystery: where (in which cell types) and when (during development) do they arise? Do they arise as a by-product of the normal reshuffling of genes between chromosome copies that occurs during meiosis, the cellular process to produce gametes (oocytes and sperm), or at some other stage in the life cycle? A genome is all of an organism’s genetic information. It is made up of DNA nucleotide sequences (or RNA in RNA viruses). The genome contains genes (coding regions) as well as noncoding DNA, mitochondrial DNA, and chloroplast DNA. The study of the genome is called genomics and is related to the fields of molecular biology and genetics. Now a research study led by scientists from the Universitat Autònoma de Barcelona (UAB) and the University of Kent shows that sperm production is key to how regions of the genome are re-organized within and between chromosomes during evolution. In particular, inherited chromosomal rearrangements are associated with physical and biochemical processes that are specific to the final stages of sperm production, after the meiotic cell divisions have been completed. Chromatin Remodeling and Genetic Recombination in Spermatogenesis The total sequence of DNA or genome of an individual is folded into a specifically tailored and dynamic 3D chromatin structure within the cell nuclei, that determines which genes are “turned on” and which are “turned off” in each cell type. Gametes are produced by all sexually reproducing organisms through a process called meiosis that involves one round of genome replication followed by two consecutive cell divisions, to leave haploid cells (gametes), carrying only one copy of each chromosome. During meiosis, genes are “shuffled” between the chromosome copies inherited from the mother and father, a process known as genetic recombination. These complex events imply that the genome must be packaged and unpackaged in a precise and highly regulated manner into chromatin. “Our work shows the dynamics of chromatin remodeling during the formation of male gametes is fundamental for understanding which parts of the genome are located close to each other inside the nucleus, and are therefore more likely to be involved in chromosomal rearrangements, in different moments throughout male spermatogenesis” throughout male spermatogenesis,” says Dr. Aurora Ruiz-Herrera, Associate Professor at the Department of Cell Biology, Physiology and Immunology of the Institute of Biotechnology and Biomedicine (IBB) at the UAB. Analyzing Genome Rearrangements in Rodents To study genome evolution, the team compared the genomes of 13 different rodent species and “unscrambled” the rearrangements that distinguish them. “This allowed us to work out the genome configuration of the rodent common ancestor and determine the locations of the evolutionary breakpoint regions (EBRs) participating in genome rearrangements,” explains Dr. Marta Farré, Lecturer in Genomics at the School of Biosciences in the University of Kent, and co-leader of the study. “Strikingly, EBRs were associated with regions that are active in later stages of spermatogenesis, when the developing male germ cells are called spermatids. Rearrangements occurring at EBRs were found to break and rejoin DNA stretches that are physically located close to each other in the spermatid nucleus,” says Dr. Peter Ellis, Senior Lecturer in Molecular Genetics and Reproduction at the School of Biosciences in the University of Kent and co-leader of the study. Furthermore, EBRs were not associated with meiotic recombination hotspots – indicating that these rearrangements most likely did not occur during meiosis in either males or females. Instead, EBRs were correlated with DNA damage locations in spermatids. Spermatids are cells undergoing the final stage of sperm development, after cell division has finished – and the events occurring during this process are male specific. This, therefore, carries the startling implication that males and females are not equal in terms of their impact on genome evolution. “Of all the rearrangements that distinguish a mouse from a rat, a squirrel, or a rabbit, the majority appear likely to have arisen in a sperm cell rather than an egg cell. For me, this shows that the male germline is the overall engine of genome structural evolution,” says Dr. Ellis. “We show that developing sperm cells retain a ‘memory’ of previous genome configurations. There are stretches of DNA that used to be part of a single chromosome in rodent common ancestor but are now located on different chromosomes in mouse – yet these still move close to each other and make physical contact specifically in developing sperm cells” says Dr. Marta Farré. Why in Male Germ Cells? The authors propose one explanation for their results is the different events that occur during egg and sperm cell production. While both sperm and egg cells reshuffle DNA during meiosis, the DNA breaks created during this process are repaired highly accurately. However, sperm cells also have to compact their DNA into a tiny volume to fit in the sperm head. This compaction causes DNA breaks and uses an error-prone method to repair the DNA. Some of these errors can generate genomic rearrangements – explaining why sperm development is a critical factor in genome evolution. On the other side, a current unsolved mystery is why some species have very stable genomes with few rearrangements, while others have highly dynamic genomes with multiple rearrangements. “Our work suggests that this may be due to the details of where and when DNA is broken and repaired during sperm production,” says Dr. Ruiz-Herrera. While the study was carried out in rodents, spermatogenesis is a highly conserved process and therefore this principle is likely to apply widely throughout the tree of life, researchers point out. Reference: “3D chromatin remodelling in the germ line modulates genome evolutionary plasticity” by Lucía Álvarez-González, Frances Burden, Dadakhalandar Doddamani, Roberto Malinverni, Emma Leach, Cristina Marín-García, Laia Marín-Gual, Albert Gubern, Covadonga Vara, Andreu Paytuví-Gallart, Marcus Buschbeck, Peter J. I. Ellis, Marta Farré and Aurora Ruiz-Herrera, 11 May 2022, Nature Communications. DOI: 10.1038/s41467-022-30296-6 Participating in this study led by the UAB and University of Kent were also the research teams from Josep Carreras Leukaemia Research Institute (IJC) and Sequentia Biotech. Fossils of the key groups used to unveil the Eocene-Oligocene extinction in Africa with primates on the left, the carnivorous hyaenodont, on the upper right, rodent, on the lower right. These fossils are from the Fayum Depression in Egypt and are stored at the Duke Lemur Center’s Division of Fossil Primates. Credit: Matt Borths, Duke University Lemur Center Fossils from Duke collection uncover a previously unknown mass extinction event in Africa. Sixty-three percent. That’s the proportion of mammal species that vanished from Africa and the Arabian Peninsula around 30 million years ago, after Earth’s climate shifted from swampy to icy. But we are only finding out about it now. Compiling decades of work, a new study published this week in the journal Communications Biology reports on a previously undocumented extinction event that followed the transition between the geological periods called the Eocene and Oligocene. That time period was marked by dramatic climate change. In a reverse image of what is happening today, the Earth grew cooler, ice sheets expanded, sea levels dropped, forests started changing to grasslands, and carbon dioxide became scarce. Nearly two-thirds of the species known in Europe and Asia at that time went extinct. African mammals were thought to have possibly escaped unscathed. Africa’s mild climate and proximity to the Equator could have been a buffer from the worst of that period’s cooling trend. Dental CT scans show that mammal teeth became less diverse during the early Oligocene extinction events. Here is an example of the three-dimensional tooth shape of a lower molar of a fossil anomaluroid rodent. Credit: Dorien de Vries, University of Salford Now, thanks in great part to a large collection of fossils housed at the Duke Lemur Center Division of Fossil Primates (DLCDFP), researchers have shown that, despite their relatively balmy environment, African mammals were just as affected as those from Europe and Asia. The collection was the life’s work of the late Elwyn Simons of Duke, who scoured Egyptian deserts for fossils for decades. The team, comprising researchers from the United States, England, and Egypt, looked at fossils of five mammal groups: a group of extinct carnivores called hyaenodonts, two rodent groups, the anomalures (scaly-tail squirrels) and the hystricognaths (a group that includes porcupines and naked mole rats), and two primate groups, the strepsirrhines (lemurs and lorises), and our very own ancestors, the anthropoids (apes and monkeys). By gathering data on hundreds of fossils from multiple sites in Africa, the team was able to build evolutionary trees for these groups, pinpointing when new lineages branched out and time-stamping each species’ first and last known appearances. Their results show that all five mammal groups suffered huge losses around the Eocene-Oligocene boundary. “It was a real reset button,” said Dorien de Vries, a postdoctoral researcher at the University of Salford and lead author of the paper. After a few million years, these groups start popping up again in the fossil record, but with a new look. The fossil species that re-appear later in the Oligocene, after the big extinction event, are not the same as those that were found before. “It’s very clear that there was a huge extinction event, and then a recovery period,” said Steven Heritage, Researcher and Digital Preparator at Duke University’s DLCDFP and coauthor of the paper. The evidence is in these animals’ teeth. Molar teeth can tell a lot about what a mammal eats, which in turn tells a lot about their environment. The rodents and primates that reappeared after a few million years had different teeth. These were new species, that ate different things, and had different habitats. “We see a huge loss in tooth diversity, and then a recovery period with new dental shapes and new adaptations,” said de Vries. “Extinction is interesting in that way,” said Matt Borths, curator of Duke University’s DLCDFP and coauthor of the paper. “It kills things, but it also opens up new ecological opportunities for the lineages that survive into this new world.” This decline in diversity followed by a recovery confirms that the Eocene-Oligocene boundary acted as an evolutionary bottleneck: most lineages went extinct, but a few survived. Over the next several millions of years, these surviving lines diversified. “In our anthropoid ancestors, diversity bottoms out to almost nothing around 30 million years ago, leaving them with a single tooth type,” said Erik R. Seiffert, Professor and Chair of the Department of Integrative Anatomical Sciences at the Keck School of Medicine of the University of Southern California, a former graduate student of Simons, and senior coauthor of the paper. “That ancestral tooth shape determined what was possible in terms of later dietary diversification.” “There’s an interesting story about the role of that bottleneck in our own early evolutionary history,” said Seiffert. “We came pretty close to never existing, if our monkey-like ancestors had gone extinct 30 million years ago. Luckily they didn’t.” A rapidly changing climate wasn’t the only challenge facing these few surviving types of mammals. As temperatures dropped, East Africa was pummeled by a series of major geological events, such as volcanic super eruptions and flood basalts – enormous eruptions that covered vast expanses with molten rock. It was also at that time that the Arabian Peninsula separated from East Africa, opening the Red Sea and the Gulf of Aden. “We lost a lot of diversity at the Eocene-Oligocene boundary,” said Borths. “But the species that survived apparently had enough of a toolkit to persist through this fluctuating climate.” “Climate changes through geological time have shaped the evolutionary tree of life,” said Hesham Sallam, founder of the Mansoura University Vertebrate Paleontology Center in Egypt and coauthor of the paper. “Collecting evidence from the past is the easiest way to learn about how climate change will affect ecological systems.” Reference: “Widespread loss of mammalian lineage and dietary diversity in the early Oligocene of Afro-Arabia” by Dorien de Vries, Steven Heritage, Matthew R. Borths, Hesham M. Sallam and Erik R. Seiffert, 7 October 2021, Communications Biology. DOI: 10.1038/s42003-021-02707-9 Funding for this study came from The Leakey Foundation, the U.S. National Science Foundation (BSC-1824745 to DD. and DBI-1612062 to MRB), and the Natural Environment Research Council (NERC NE/T000341/1). Field work in the Fayum Depression, Egypt, and digital curation of Fayum fossils were supported by the U.S. National Science Foundation (BCS-0416164, BCS-0819186, and BCS-1231288) as well as Gordon and Ann Getty and The Leakey Foundation. Micro-CT scanning was partially supported by NSF grant DBI-1458192, DBI-2023087, and IMLS grant MA-245704-OMS-20. New research has uncovered significant age-related changes in lipid metabolism across different organs and sexes in mice, highlighting the accumulation of specific lipids produced by gut bacteria. The findings, which also include the identification of a gene causing sex differences in the kidneys, could improve our understanding of age-related diseases like Alzheimer’s and atherosclerosis. This research provides a foundation for future studies on the human lipidome and microbiome, potentially leading to targeted treatments for these conditions. Credit: RIKEN RIKEN Center researchers have found key age-related changes in mice’s lipid metabolism, potentially improving treatments for age-related diseases. Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have identified multiple age-related alterations in lipid metabolism in mice, affecting various organs and differing by sex. Notably, they observed a systemic accumulation of specific lipids originating from gut bacteria as the mice aged. Additionally, the study revealed a sex-related difference in the kidneys and identified a gene linked to this variation. Published in Nature Aging, these findings could enhance our understanding of chronic age-related diseases such as Alzheimer’s, atherosclerosis, kidney disease, and cancer. Lipids, often in the form of fats or oils, are essential molecules for storing energy in our bodies, among other things. In addition, lipids act as signaling molecules and as components of cell membranes. Metabolism—the breakdown of biomolecules such as lipids and sugars into their component parts—slows down as we age, which helps explain why it’s easier to gain weight, and more difficult to lose it, as we get older. Although this has been known for over 50 years, how changes in lipid metabolism in particular affects lifespan and health remain unclear. In their recent study, Hiroshi Tsugawa and his team at RIKEN IMS reasoned that before this question can be fully answered, we need to know what the actual changes are, in great detail. Only then can scientists begin looking for links between aging lipid metabolism and human health. Toward this end, they used mice to develop an atlas of age-related changes in lipid metabolites. By using a cutting-edge technique to take multiple snapshots of the mouse lipidome—all lipid metabolites present in a biological sample—the researchers found that BMP-type lipids increased with age in the kidneys, liver, lungs, muscles, spleen, and small intestine of the mice. These lipids play key roles in cholesterol transport and the breakdown of biomolecules within cellular recycling centers called lysosomes. Age-related lysosomal damage might result in cells making more BMPs, which could lead to further metabolic changes, such as increasing cholesterol derivatives in the kidney. Gut Bacteria and Lipid Changes The researchers also investigated the impact of gut bacteria on the lipidome, discovering that while gut bacteria produced many structurally unique lipids, only sulfonolipids increased with age in the liver, kidney, and spleen. In fact, no other group of lipid metabolites from gut bacteria were even detected in these peripheral tissues. “As this kind of lipid is known to be involved in regulating immune responses, the next phase of our research will involve testing the gut bacteria-derived sulfonolipids to determine their structure and physiological functions,” says Tsugawa. The researchers also found age-related sex differences in the mouse lipidome, particularly in the kidneys, with levels of the lipid metabolite galactosylceramide being higher in older male mice than in older females. This discrepancy was attributed to increased expression of the UGT8 gene in male mice. Understanding sex-specific metabolic differences like this could shed light on susceptibility to age-related diseases in humans. “Our research has comprehensively characterized the changes in the lipidome that occur in the mouse with aging. In doing so, we have created at atlas that will serve as an important global resource,” says Tsugawa. “Next, we must extend this type of study to the human lipidome and microbiome.” The findings highlight the importance of understanding how lipid metabolism changes as we age, and the potential of targeting the lipidome when designing treatments for age-related diseases. Reference: “A lipidome landscape of aging in mice” by Hiroshi Tsugawa, Tomoaki Ishihara, Kota Ogasa, Seigo Iwanami, Aya Hori, Mikiko Takahashi, Yutaka Yamada, Naoko Satoh-Takayama, Hiroshi Ohno, Aki Minoda and Makoto Arita, 12 April 2024, Nature Aging. DOI: 10.1038/s43587-024-00610-6 RRG455KLJIEVEWWF |
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