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 加分100%浜中特選昆布鍋物節慶時段會不會太難訂位？》公益路餐廳推薦Top10｜吃貨親訪真實心得 |
| 時事評論｜環保生態 2026/04/22 13:13:15 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 印月餐廳團體宴客合適嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。一頭牛日式燒肉家庭聚餐合適嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。KoDō 和牛燒肉適合辦尾牙嗎？ 下一餐，不妨從這10家開始。加分100%浜中特選昆布鍋物適合多人分享嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。茶六燒肉堂用餐環境舒服嗎？ 如果你有私心愛店，也歡迎留言分享，KoDō 和牛燒肉值得專程去嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。一頭牛日式燒肉小孩適合去嗎？ Research shows new brain pathways in the striatum modulate dopamine, linking movement control to emotional decisions, enhancing our understanding of motivation. Credit: SciTechDaily.com MIT researchers have uncovered two additional pathways in the brain’s striatum that modulate traditional movement control pathways by influencing dopamine production. These pathways, connected to the brain’s striosomes, may play a crucial role in decisions with strong emotional components, potentially altering our understanding of how motivation and movement are interconnected. In the human brain, movement is coordinated by a region called the striatum, which sends signals to motor neurons. These signals travel along two main pathways: one initiates movement (“go”), and the other inhibits it (“no-go”). In a recent study, MIT researchers discovered two additional pathways within the striatum that seem to fine-tune the go and no-go pathways. These new pathways connect to dopamine-producing neurons in the brain, with one pathway stimulating dopamine release and the other suppressing it. Modulation of Dopamine by Striosomes Through clusters of neurons called striosomes, these pathways control dopamine levels and modify the instructions sent by the go and no-go pathways. The researchers suggest that this mechanism may play a key role in decisions involving strong emotions. “Among all the regions of the striatum, the striosomes alone turned out to be able to project to the dopamine-containing neurons, which we think has something to do with motivation, mood, and controlling movement,” says Ann Graybiel, an MIT Institute Professor, a member of MIT’s McGovern Institute for Brain Research, and the senior author of the new study. Iakovos Lazaridis, a research scientist at the McGovern Institute, is the lead author of the paper, which was published on October 23 in the journal Current Biology. Structural Insights Into the Striatum Graybiel has spent much of her career studying the striatum, a structure located deep within the brain that is involved in learning and decision-making, as well as control of movement. Within the striatum, neurons are arranged in a labyrinth-like structure that includes striosomes, which Graybiel discovered in the 1970s. The classical go and no-go pathways arise from neurons that surround the striosomes, which are known collectively as the matrix. The matrix cells that give rise to these pathways receive input from sensory processing regions such as the visual cortex and auditory cortex. Then, they send go or no-go commands to neurons in the motor cortex. The Mystery of Striosome Function However, the function of the striosomes, which are not part of those pathways, remained unknown. For many years, researchers in Graybiel’s lab have been trying to solve that mystery. Their previous work revealed that striosomes receive much of their input from parts of the brain that process emotion. Within striosomes, there are two major types of neurons, classified as D1 and D2. In a 2015 study, Graybiel found that one of these cell types, D1, sends input to the substantia nigra, which is the brain’s major dopamine-producing center. It took much longer to trace the output of the other set, D2 neurons. In the new Current Biology study, the researchers discovered that those neurons also eventually project to the substantia nigra, but first they connect to a set of neurons in the globus palladus, which inhibits dopamine output. This pathway, an indirect connection to the substantia nigra, reduces the brain’s dopamine output and inhibits movement. Dopamine Pathways and Movement The researchers also confirmed their earlier finding that the pathway arising from D1 striosomes connects directly to the substantia nigra, stimulating dopamine release and initiating movement. “In the striosomes, we’ve found what is probably a mimic of the classical go/no-go pathways,” Graybiel says. “They’re like classic motor go/no-go pathways, but they don’t go to the motor output neurons of the basal ganglia. Instead, they go to the dopamine cells, which are so important to movement and motivation.” Rethinking the Classical Model of Movement The findings suggest that the classical model of how the striatum controls movement needs to be modified to include the role of these newly identified pathways. The researchers now hope to test their hypothesis that input related to motivation and emotion, which enters the striosomes from the cortex and the limbic system, influences dopamine levels in a way that can encourage or discourage action. That dopamine release may be especially relevant for actions that induce anxiety or stress. In their 2015 study, Graybiel’s lab found that striosomes play a key role in making decisions that provoke high levels of anxiety; in particular, those that are high risk but may also have a big payoff. “Ann Graybiel and colleagues have earlier found that the striosome is concerned with inhibiting dopamine neurons. Now they show unexpectedly that another type of striosomal neuron exerts the opposite effect and can signal reward. The striosomes can thus both up- or down-regulate dopamine activity, a very important discovery. Clearly, the regulation of dopamine activity is critical in our everyday life with regard to both movements and mood, to which the striosomes contribute,” says Sten Grillner, a professor of neuroscience at the Karolinska Institute in Sweden, who was not involved in the research. Future Research Avenues: Motor Modules and Parkinson’s Another possibility the researchers plan to explore is whether striosomes and matrix cells are arranged in modules that affect motor control of specific parts of the body. “The next step is trying to isolate some of these modules, and by simultaneously working with cells that belong to the same module, whether they are in the matrix or striosomes, try to pinpoint how the striosomes modulate the underlying function of each of these modules,” Lazaridis says. They also hope to explore how the striosomal circuits, which project to the same region of the brain that is ravaged by Parkinson’s disease, may influence that disorder. Reference: “Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits” by Iakovos Lazaridis, Jill R. Crittenden, Gun Ahn, Kojiro Hirokane, Ian R. Wickersham, Tomoko Yoshida, Ara Mahar, Vasiliki Skara, Johnny H. Loftus, Krishna Parvataneni, Konstantinos Meletis, Jonathan T. Ting, Emily Hueske, Ayano Matsushima and Ann M. Graybiel, 23 October 2024, Current Biology. DOI: 10.1016/j.cub.2024.09.070 The research was funded by the National Institutes of Health, the Saks-Kavanaugh Foundation, the William N. and Bernice E. Bumpus Foundation, Jim and Joan Schattinger, the Hock E. Tan and K. Lisa Yang Center for Autism Research, Robert Buxton, the Simons Foundation, the CHDI Foundation, and an Ellen Schapiro and Gerald Axelbaum Investigator BBRF Young Investigator Grant. Stock photo illustrating a plant growing on the moon. Scientists have grown plants in soil from the Moon, a first in human history and a watershed moment in lunar and space exploration. In a new research paper published in the journal Communications Biology on May 12, 2022, University of Florida scientists showed that plants can successfully sprout and grow in lunar soil. Their study also looked into how plants respond biologically to the Moon’s soil, also known as lunar regolith, which is radically different from typical soil found on Earth. This research is a first step toward growing plants for food and oxygen on the Moon or during space missions in the future. More immediately, this research comes as the Artemis Program plans to return humans to the Moon. “Artemis will require a better understanding of how to grow plants in space,” said Rob Ferl, one of the study’s authors and a distinguished professor of horticultural sciences in the UF Institute of Food and Agricultural Sciences (UF/IFAS). Anna-Lisa Paul, left, and Rob Ferl, working with lunar soils in their lab. Credit: UF/IFAS photo by Tyler Jones Even in the early days of lunar exploration, plants played an important role, said Anna-Lisa Paul, also one of the study’s authors and a research professor of horticultural sciences in UF/IFAS. “Plants helped establish that the soil samples brought back from the moon did not harbor pathogens or other unknown components that would harm terrestrial life, but those plants were only dusted with the lunar regolith and were never actually grown in it,” Paul said. Paul and Ferl are internationally recognized experts in the study of plants in space. Through the UF Space Plants Lab, they have sent experiments on space shuttles, to the International Space Station, and on suborbital flights. Anna-Lisa Paul tries moistening the lunar soils with a pipette. The scientists found that the soils repelled water (were hydrophobic), causing the water to bead-up on the surface. Active stirring of the material with water was required to break the hydrophobicity and uniformly wet the soil. Once moistened, the lunar soils could be wetted by capillary action for plant culture. Credit: UF/IFAS photo by Tyler Jones “For future, longer space missions, we may use the Moon as a hub or launching pad. It makes sense that we would want to use the soil that’s already there to grow plants,” Ferl said. “So, what happens when you grow plants in lunar soil, something that is totally outside of a plant’s evolutionary experience? What would plants do in a lunar greenhouse? Could we have lunar farmers?” To begin to answer these questions, Ferl and Paul designed a deceptively simple experiment: plant seeds in lunar soil, add water, nutrients, and light, and record the results. Arabidopsis plants 6 days after the seeds were planted. The four wells on the left contain plants growing in JSC-1A lunar soil simulant. The three wells on the right contain plants growing in lunar soils collected during the Apollo 11, 12, and 17 missions. Credit: UF/IFAS photo by Tyler Jones The complication: The scientists only had 12 grams — just a few teaspoons — of lunar soil with which to do this experiment. On loan from NASA, this soil was collected during the Apollo 11, 12, and 17 missions to the Moon. Paul and Ferl applied three times over the course of 11 years for a chance to work with the lunar regolith. The small amount of soil, not to mention its incalculable historical and scientific significance, meant that Paul and Ferl had to design a small scale, carefully choreographed experiment. To grow their tiny lunar garden, the researchers used thimble-sized wells in plastic plates normally used to culture cells. Each well functioned as a pot. Once they filled each “pot” with approximately a gram of lunar soil, the scientists moistened the soil with a nutrient solution and added a few seeds from the Arabidopsis plant. Arabidopsis is widely used in the plant sciences because its genetic code has been fully mapped. Growing Arabidopsis in the lunar soil allowed the researchers more insight into how the soil affected the plants, down to the level of gene expression. Rob Ferl, left, and Anna-Lisa Paul looking at the plates filled part with lunar soil and part with control soils, now under LED growing lights. At the time, the scientists did not know if the seeds would even germinate in lunar soil. Credit: UF/IFAS photo by Tyler Jones As points of comparison, the researchers also planted Arabidopsis in JSC-1A, a terrestrial substance that mimics real lunar soil, as well as simulated Martian soils and terrestrial soils from extreme environments. The plants grown in these non-lunar soils were the experiment’s control group. Coping with the Challenges of Lunar Soil Before the experiment, the researchers weren’t sure if the seeds planted in the lunar soils would sprout. But nearly all of them did. “We were amazed. We did not predict that,” Paul said. “That told us that the lunar soils didn’t interrupt the hormones and signals involved in plant germination.” However, as time went on, the researchers observed differences between the plants grown in lunar soil and the control group. For example, some of the plants grown in the lunar soils were smaller, grew more slowly, or were more varied in size than their counterparts. These were all physical signs that the plants were working to cope with the chemical and structural make-up of the Moon’s soil, Paul explained. This was further confirmed when the researchers analyzed the plants’ gene expression patterns. “At the genetic level, the plants were pulling out the tools typically used to cope with stressors, such as salt and metals or oxidative stress, so we can infer that the plants perceive the lunar soil environment as stressful,” Paul said. “Ultimately, we would like to use the gene expression data to help address how we can ameliorate the stress responses to the level where plants — particularly crops — are able to grow in lunar soil with very little impact to their health.” Insights for Future Space Agriculture How plants respond to lunar soil may be linked to where the soil was collected, said Ferl and Paul, who collaborated on the study with Stephen Elardo, an assistant professor of geology at UF. For instance, the researchers found that the plants with the most signs of stress were those grown in what lunar geologists call mature lunar soil. These mature soils are those exposed to more cosmic wind, which alters their makeup. On the other hand, plants grown in comparatively less mature soils fared better. Growing plants in lunar soils may also change the soils themselves, Elardo said. “The Moon is a very, very dry place. How will minerals in the lunar soil respond to having a plant grown in them, with the added water and nutrients? Will adding water make the mineralogy more hospitable to plants?” Elardo said. Follow-up studies will build on these questions and more. For now, the scientists are celebrating having taken the first steps toward growing plants on the Moon. “We wanted to do this experiment because, for years, we were asking this question: Would plants grow in lunar soil,” Ferl said. “The answer, it turns out, is yes.” Reference: “Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration” by Anna-Lisa Paul, Stephen M. Elardo and Robert Ferl, 12 May 2022, Communications Biology. DOI: 10.1038/s42003-022-03334-8 Gut section with fluorescently labeled bacteria. Credit: Huimin Ye An international team of scientists led by microbiologists Professor Alexander Loy from the University of Vienna and Professor David Schleheck from the University of Konstanz has uncovered new metabolic capabilities of gut bacteria. For the first time, the researchers have analyzed how microbes in the gut process the plant-based, sulfur-containing sugar sulfoquinovose. Sulfoquinovose is a sulfonic acid derivative of glucose and is found in all green vegetables such as spinach and lettuce. Their study discovered that specialized bacteria cooperate in the utilization of the sulfosugar, producing hydrogen sulfide. This gas — known for its rotten egg smell — has disparate effects on human health: at low concentrations, it has an anti-inflammatory effect, while increased amounts of hydrogen sulfide in the intestine, in turn, are associated with diseases such as cancer. The study has been published in the current issue of The ISME Journal. Diet and the gut microbiome With the consumption of a single type of vegetable such as spinach, hundreds of chemical components enter our digestive tract. There, they are further metabolized by the gut microbiome, a unique collection of hundreds of microbial species. The gut microbiome thus plays a major role in determining how nutrition affects our health. “So far, however, the metabolic capabilities of many of these microorganisms in the microbiome are still unknown. That means we don’t know what substances they feed on and how they process them,” explains Buck Hanson, lead author of the study and a microbiologist at the Center for Microbiology and Environmental Systems Science (CMESS) at the University of Vienna. “By exploring the microbial metabolism of the sulfosugar sulfoquinovose in the gut for the first time, we have shed some light into this black box,” he adds. The study thus generates knowledge that is necessary to therapeutically target the interactions between nutrition and the microbiome in the future. Sulfosugars from green plants and algae Sulfoquinovose is a sulfonic acid derivative of glucose and is found as a chemical building block primarily in green vegetables such as spinach, lettuce, and algae. From previous studies by the research group led by microbiologist David Schleheck at the University of Konstanz, it was known that other microorganisms can in principle use the sulfosugar as a nutrient. In their current study, the researchers from the Universities of Konstanz and Vienna used analyses of stool samples to determine how these processes specifically take place in the human intestine. “We have now been able to show that, unlike glucose, for example, which feeds a large number of microorganisms in the gut, sulfoquinovose stimulates the growth of very specific key organisms in the gut microbiome,” says David Schleheck. These key organisms include the bacterium of the species Eubacterium rectale, which is one of the ten most common gut microbes in healthy people. “The E. rectale bacteria ferment sulfoquinovose via a metabolic pathway that we have only recently deciphered, producing, among other things, a sulfur compound, dihydroxypropane sulfonate or DHPS for short, which in turn serves as an energy source for other intestinal bacteria such as Bilophila wadsworthia. Bilophila wadsworthia ultimately produces hydrogen sulfide from DHPS via a metabolic pathway that was also only recently discovered,” explains the microbiologist. A question of dose: hydrogen sulfide in the intestine Hydrogen sulfide is produced in the intestine by our own body cells as well as by specialized microorganisms and has a variety of effects on our body. “This gas is a Janus-faced metabolic product,” explains Alexander Loy, head of the research group at the University of Vienna. “According to current knowledge, it can have a positive but also a negative effect on intestinal health.” A decisive factor, he says, is the dose: In low amounts, hydrogen sulfide can have an anti-inflammatory effect on the intestinal mucosa, among other things. Increased hydrogen sulfide production by gut microbes, on the other hand, is associated with chronic inflammatory diseases and cancer. Until now, mainly sulfate and taurine, which are found in increased amounts in the intestine as a result of a diet rich in meat or fat, were known to be sources of hydrogen sulfide for microorganisms. The discovery that sulfoquinovose from green foods such as spinach and algae also contribute to the production of the gas in the gut therefore comes as a surprise. “We have shown that we can use sulfoquinovose to promote the growth of very specific gut bacteria that are an important component of our gut microbiome. We now also know that these bacteria in turn produce the contradictory hydrogen sulfide from it,” Loy sums up. Further studies by the scientists from Konstanz and Vienna will now clarify whether and how the intake of the plant-based sulfosugar can have a health-promoting effect. “It is also possible that sulfoquinovose could be used as a so-called prebiotic,” adds Schleheck. Prebiotics are food ingredients or additives that are metabolized by specific microorganisms and used to explicitly support the intestinal microbiome. Key facts: Study shows that the sulfosugar sulfoquinovose from green vegetables promotes the growth of important gut bacteria Specialized bacteria cooperate in the utilization of the sulfosugar sulfoquinovose, producing hydrogen sulfide, which has an anti-inflammatory effect in low concentrations, while increased amounts are associated with diseases such as cancer Joint study by the Universities of Konstanz and Vienna involving the research groups led by the microbiologists Professor David Schleheck from the University of Konstanz and Professor Alexander Loy from the University of Vienna References: “Sulfoquinovose is a select nutrient of prominent bacteria and a source of hydrogen sulfide in the human gut” by Buck T. Hanson, K. Dimitri Kits, Jessica Löffler, Anna G. Burrichter, Alexander Fiedler, Karin Denger, Benjamin Frommeyer, Craig W. Herbold, Thomas Rattei, Nicolai Karcher, Nicola Segata, David Schleheck and Alexander Loy, 31 March 2021, The ISME Journal. DOI: 10.1038/s41396-021-00968-0 “Environmental and Intestinal Phylum Firmicutes Bacteria Metabolize the Plant Sugar Sulfoquinovose via a 6-Deoxy-6-sulfofructose Transaldolase Pathway” by Benjamin Frommeyer, Alexander W. Fiedler, Sebastian R. Oehler, Buck T. Hanson, Alexander Loy, Paolo Franchini, Dieter Spiteller and David Schleheck, 28 August 2020, iScience. DOI: 10.1016/j.isci.2020.101510 Funding: The work of Professor Schleheck’s group at the University of Konstanz is funded by the German Research Foundation (DFG) RRG455KLJIEVEWWF |
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