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文章數：75 |
 加分100%浜中特選昆布鍋物單點比較好嗎？》公益路愛店推薦｜台中10間美食評比 |
| 興趣嗜好｜偶像追星 2026/04/20 18:08:40 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 三希樓適合辦部門小聚嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。KoDō 和牛燒肉家庭聚餐合適嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。茶六燒肉堂座位舒適嗎？ 下一餐，不妨從這10家開始。三希樓用餐時間會不會太短？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。加分100%浜中特選昆布鍋物份量足夠嗎？ 如果你有私心愛店，也歡迎留言分享，一頭牛日式燒肉座位舒適嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。一笈壽司有提供尾牙方案嗎？ Weedy seadragon (Phyllopteryx taeniolatus) Seadragons (Phyllopetryx taeniolatus) live off the coast in western and southern Australia. An international team involving evolutionary biologist Axel Meyer from the University of Konstanz has now found the genetic basis for some external characteristics of the seadragon, like its lack of teeth and its distinct leaf-like appendages. The team also localized the sex-determination gene in the seadragon genome. The study was published on August 18, 2021, in Science Advances. Experts in camouflage Seadragons belong to the family Syngnathidae along with seahorses and pipefishes. Their name refers to the dragon-like shape of their bodies and the spectacular coloring of their special leaf-like skin appendages. They are considered experts in camouflage because of their ability to mimic the appearance of seaweed. Like the other members of the Syngnathidae family, seadragons exhibit special adaptations and behaviors: They have a tube-shaped, toothless mouths, they lack the ventral and pelvic fins and scales typical for fish, but they instead have a bony shell covering their entire bodies. Dried seahorses are used in traditional Chinese medicine, which has led to many species being highly endangered. They do not swim horizontally, but instead glide slowly through coral reefs and shallow coastal waters, almost vertically – like a horse – with their heads bent downwards. Their prehensile tail can be used to hold on to things. Like other seahorse species, the seadragon males are responsible for protecting the bright pink eggs attached to the outside of their bodies until they hatch. The genome of the seadragon, a very unusual fish, has been decoded. New insights help answer the question of evolutionary invention – Results of an international research team including Konstanz-based evolutionary biologist Axel Meyer published in Science Advances. Credit: University of Konstanz While sequencing the genome and examining the genetic basis for other external characteristics of seadragons, researchers from five teams from China, Singapore, Japan and Germany focussed their efforts on sex-determination, toothlessness and newly-evolved skin appendages in seadragons. The research team, led by Professor Qiang Lin from the Chinese Academy of Sciences in Guangzhou, showed that a series of genes is responsible for this evolutionary development that usually control fin development. The leaf-like skin appendages of the seadragons are thus highly altered fin rays. Like seahorses, seadragons are also toothless. They use their long snouts to suck in their food, small crustaceans, and swallow them whole. The genome analysis shows that, in the seahorse relatives, too, several genes are missing that contribute to the development of teeth in other fishes as well as in humans. The research team tested the hypothesis about the corresponding scpp5 gene by switching off this gene in zebra fish, a well-researched model organism with pharyngeal teeth. As expected, the mutated fish displayed reduced teeth. The function of the missing gene responsible for tooth loss was thus proven in molecular-biological CRISPR-Cas experiments. Males care for fertilized eggs It is also typical that male members of the seahorse family care for fertilized eggs until they hatch. Seahorse males have developed brood pouches, but males of the older seadragon species still carry the sticky eggs visibly on their tails. The females lay the eggs onto this special location on the males’ bodies, and they are then carried around by the male seadragons and thus protected from predators. It is generally more common that male fish care for fertilized eggs rather than females, although this particular form has only evolved in members of the seahorse family. In this context, the researchers looked for sex-determination mechanisms that were previously unknown in seadragons. On the whole, it is difficult to localize sex-determination in fish, since, for the most part, they do not have special sex chromosomes, like the X and Y chromosomes in mammals. The team found the molecular basis for sex-determination in seadragons to be in the Mullerian hormone, as had previously also been documented for seahorses. The sequencing of the seadragon genome was completed as part of an additional project in the context of a long-term collaboration between the research teams in Guangzhou and Konstanz. The first publication – on first the seahorse genome – was published by both teams in 2016 in Nature, with a second one with 21 new seahorse genomes appeared this year in Nature Communications. Axel Meyer: “Our research into the genome seeks to derive the corresponding phenotype or “essence” of these animals. We are striving to understand what an animal looks like based on its sequence of genomes and our understanding of the genes’ function. Seadragons are fish that do not look like typical fish at all. They are a particularly fascinating and beautiful species.” Reference: “Seadragon genome analysis provides insights into its phenotype and sex determination locus” by Meng Qu, Yali Liu, Yanhong Zhang, Shiming Wan, Vydianathan Ravi, Geng Qin, Han Jiang, Xin Wang, Huixian Zhang, Bo Zhang, Zexia Gao, Ann Huysseune, Zhixin Zhang, Hao Zhang, Zelin Chen, Haiyan Yu, Yongli Wu, Lu Tang, Chunyan Li, Jia Zhong, Liming Ma, Fengling Wang, Hongkun Zheng, Jianping Yin, Paul Eckhard Witten, Axel Meyer, Byrappa Venkatesh and Qiang Lin, 18 August 2021, Science Advances. DOI: 10.1126/sciadv.abg5196 Key facts: Study on the genetic basis for the phenotype of the seadragon and the genetic mechanism behind sex-determination Research collaboration of five teams from China, Singapore, Japan and Germany, including evolutionary biologist Professor Axel Meyer Quadruple-helix DNA structure. Credit: Imperial College London New probes allow scientists to see four-stranded DNA interacting with molecules inside living human cells, unraveling its role in cellular processes. DNA usually forms the classic double helix shape of two strands wound around each other. While DNA can form some more exotic shapes in test tubes, few are seen in real living cells. “G-quadruplexes play an important role in a wide variety of processes vital for life, and in a range of diseases, but the missing link has been imaging this structure directly in living cells.” Ben Lewis However, four-stranded DNA, known as G-quadruplex, has recently been seen forming naturally in human cells. Now, in new research published in Nature Communications, a team led by Imperial College London scientists have created new probes that can see how G-quadruplexes are interacting with other molecules inside living cells. G-quadruplexes are found in higher concentrations in cancer cells, so are thought to play a role in the disease. The probes reveal how G-quadruplexes are ‘unwound’ by certain proteins, and can also help identify molecules that bind to G-quadruplexes, leading to potential new drug targets that can disrupt their activity. Needle in a Haystack One of the lead authors, Ben Lewis, from the Department of Chemistry at Imperial, said: “A different DNA shape will have an enormous impact on all processes involving it – such as reading, copying, or expressing genetic information. “Evidence has been mounting that G-quadruplexes play an important role in a wide variety of processes vital for life, and in a range of diseases, but the missing link has been imaging this structure directly in living cells.” G-quadruplexes are rare inside cells, meaning standard techniques for detecting such molecules have difficulty detecting them specifically. Ben Lewis describes the problem as “like finding a needle in a haystack, but the needle is also made of hay”. To solve the problem, researchers from the Vilar and Kuimova groups in the Department of Chemistry at Imperial teamed up with the Vannier group from the Medical Research Council’s London Institute of Medical Sciences. Fluorescence lifetime imaging microscopy map of nuclear DNA in live cells stained with the new probe. Colours represent fluorescence lifetimes between 9 (red) and 13 (blue) nanoseconds. Credit: Imperial College London They used a chemical probe called DAOTA-M2, which fluoresces (lights up) in the presence of G-quadruplexes, but instead of monitoring the brightness of fluorescence, they monitored how long this fluorescence lasts. This signal does not depend on the concentration of the probe or of G-quadruplexes, meaning it can be used to unequivocally visualize these rare molecules. Dr. Marina Kuimova, from the Department of Chemistry at Imperial, said: “By applying this more sophisticated approach we can remove the difficulties which have prevented the development of reliable probes for this DNA structure.” Looking Directly in Live Cells The team used their probes to study the interaction of G-quadruplexes with two helicase proteins – molecules that ‘unwind’ DNA structures. They showed that if these helicase proteins were removed, more G-quadruplexes were present, showing that the helicases play a role in unwinding and thus breaking down G-quadruplexes. “Many researchers have been interested in the potential of G-quadruplex binding molecules as potential drugs for diseases such as cancers. Our method will help to progress our understanding of these potential new drugs.” Professor Ramon Vilar Dr. Jean-Baptiste Vannier, from the MRC London Institute of Medical Sciences and the Institute of Clinical Sciences at Imperial, said: “In the past we have had to rely on looking at indirect signs of the effect of these helicases, but now we take a look at them directly inside live cells.” They also examined the ability of other molecules to interact with G-quadruplexes in living cells. If a molecule introduced to a cell binds to this DNA structure, it will displace the DAOTA-M2 probe and reduce its lifetime, i.e. how long the fluorescence lasts. This allows interactions to be studied inside the nucleus of living cells, and for more molecules, such as those which are not fluorescent and can’t be seen under the microscope, to be better understood. Professor Ramon Vilar, from the Department of Chemistry at Imperial, explained: “Many researchers have been interested in the potential of G-quadruplex binding molecules as potential drugs for diseases such as cancers. Our method will help to progress our understanding of these potential new drugs.” Peter Summers, another lead author from the Department of Chemistry at Imperial, said: “This project has been a fantastic opportunity to work at the intersection of chemistry, biology, and physics. It would not have been possible without the expertise and close working relationship of all three research groups.” The three groups intend to continue working together to improve the properties of their probe and to explore new biological problems and shine further light on the roles G-quadruplexes play inside our living cells. The research was funded by Imperial’s Excellence Fund for Frontier Research. Reference: “Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy” by Peter A. Summers, Benjamin W. Lewis, Jorge Gonzalez-Garcia, Rosa M. Porreca, Aaron H. M. Lim, Paolo Cadinu, Nerea Martin-Pintado, David J. Mann, Joshua B. Edel, Jean Baptiste Vannier, Marina K. Kuimova and Ramon Vilar, 8 January 2021, Nature Communications. DOI: 10.1038/s41467-020-20414-7 The MYC gene drives muscle growth and adapts to exercise but wanes with age, affecting recovery. Research shows MYC alone can mimic exercise effects, though its oncogenic risks demand cautious therapeutic approaches. A recent study investigates the relationship between exercise and the expression of MYC in skeletal muscles over time, revealing that even minimal doses can promote muscle growth without physical activity. Researchers have long known that there is a relationship between the cancer-associated gene MYC (pronounced “Mick”) and exercise adaptation. When human muscles are exercised, MYC is found to increase transiently in abundance over 24 hours. But as we age, the MYC response to exercise is blunted, perhaps explaining a reduced ability to recover from exercise and maintain or gain muscle. Knowing the precise mechanisms by which MYC drives muscle growth could prove instrumental in creating therapies that reduce muscle loss from aging, potentially improving independence, mobility, and health. New research published in EMBO Reports now adds an important dimension to our understanding of the role of MYC in skeletal muscle. The work is the product of 20 authors representing five institutions: the U of A, the Karolinska Institute in Sweden, Linköping University in Sweden, Oakland University, and the University of Kentucky. Given so many contributors, the paper is rich with data but essentially boils down to two parts. The first is a 24-hour chronicle of the molecular landscape of the human muscles following resistance exercise. The second half examines the use of mouse models to determine if controlled doses, or pulses, of MYC within skeletal muscles would be enough to stimulate muscle growth independent of actual exercise. The short answer: yes. The Molecular Landscape of MYC Co-first author Ronald Jones, a Ph.D. candidate in the U of A’s Department of Health, Human Performance and Recreation, noted that most studies tend to look at the molecular landscape of the human body by taking biopsies prior to exercise and then a few hours later. But by taking multiple biopsies over a period of 24 hours, which the team in Sweden oversaw, the researchers were able to get a more complete profile of how the body adapts to exercise over time and what genes are most important in that process. “We show that the peak of responsiveness and where most things were happening was actually eight hours after exercise,” Jones explained. He added that they found that three hours after exercising, MYC ranked as the third most important molecule. “And then at eight and 24 hours, it was the most influential. So it was really important to get those time points and to map out the body’s response to acute exercise.” Ronald Jones. Credit: University of Arkansas Once the researchers had a clearer understanding of what was happening molecularly in human muscles over time, they wanted to isolate MYC and see if it alone was enough to facilitate muscle growth. This was done by genetically controlling the levels of MYC in their skeletal muscles using a specialized mouse model. The mice weren’t given an exercise wheel, which would naturally promote muscle growth, but were otherwise allowed to move around normally. Samples were then taken from the soleus muscles of their lower legs, which are utilized in basic activities like standing or walking around. Analysis confirmed that MYC alone led to increased muscle mass and fiber size in the soleus in comparison to genetically identical mice that did not have MYC pulses but otherwise lived under identical circumstances. Thus, the team was able to effectively “mimic” the exercise response without exercise. The Meaning of MYC These findings further the argument that MYC is a key player in muscle growth from resistance training. Even so, MYC is not likely to be the basis of a new therapy for sarcopenia or a performance-enhancing drug. MYC regulates roughly 15 percent of the estimated 20,000 genes in the human body, meaning it could have unpredictable downstream effects involving thousands of genes. It is also a potent oncogene, meaning the very growth it promotes in skeletal muscle could stimulate cellular proliferation if overexpressed in organs like the liver, resulting in tumors. Administering MYC alone could have unintended and deadly side effects. Kevin Murach, an assistant professor at the U of A and Jones’ adviser in the department, was a senior and corresponding author on the paper. Murach commented that “it’s interesting that one of the things that is known to cause cancer also regulates the muscle growth response to exercise. This suggests shared regulation and that ‘growth is growth.’” Murach added, “The take-home isn’t necessarily that we need to induce MYC in muscle to mimic exercise, but that we can harness the knowledge of what this oncogene affects in muscle and then try to design therapies and interventions for atrophy and enhancing muscle adaptability that activate those positive downstream effects of MYC without evoking the possibility of oncogenesis.” In addition to being an oncogene, MYC is also one of the four Yamanaka factors, which are four protein transcription factors that can revert highly specified cells (such as a skin cell) back to a stem cell, which is a younger and more adaptable state. In the correct dosages, inducing the Yamanaka factors throughout the body in rodents can ameliorate the hallmarks of aging by mimicking the adaptability that is common to more youthful cells. Of the four factors, only MYC is induced by exercising skeletal muscle. These findings provide further motivation for the researchers to understand what MYC is doing in muscle from an aging context with exercise. Moving forward, Jones will continue to dig deeper into the mysteries of MYC as the focus of his dissertation. “I’m super passionate about it,” he said. “I wake up every day thinking about this project. I love working on this project, and I think MYC is one of the most heavily influential molecules in muscle tissue… but there is still so much we don’t know.” Reference: “The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth” by Sebastian Edman, Jones IIIRonald G, Paulo R Jannig, Rodrigo Fernandez-Gonzalo, Jessica Norrbom, Nicholas T Thomas, Sabin Khadgi, Pieter J Koopmans, Francielly Morena, Toby L Chambers, Calvin S Peterson, Logan N Scott, Nicholas P Greene, Vandre C Figueiredo, Christopher S Fry, Liu Zhengye, Johanna T Lanner, Yuan Wen, Björn Alkner, Kevin A Murach and Ferdinand von Walden, 30 October 2024, EMBO Reports. DOI: 10.1038/s44319-024-00299-z Joining Jones and Murach as co-authors on the paper from the U of A are Sabin Khadgi, a research technician for muscle physiology; PJ Koopmans, a Ph.D. candidate; Toby Chambers, a post-doctoral scholar; Francielly Morena, a recent U of A Ph.D. graduate; and Nicholas Greene, a professor and director of the Exercise Science Research Center. RRG455KLJIEVEWWF |
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