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加分100%浜中特選昆布鍋物團體宴客合適嗎?》公益路必吃美食Top10|高質感餐廳大集合 |
| 創作|散文 2026/04/20 09:17:50 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人,臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」,從精緻西餐到創意火鍋,從日式丼飯到義式早午餐,每走幾步,就會有完全不同的特色料理餐廳。 這次我特別花了一整個月,實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店,也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準,整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你,找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型,從高質感牛排館到巷弄系早午餐,每一間都有自己獨特的風格。為了讓整體比較更客觀,我依照以下四大面向進行評比,並搭配實際用餐體驗來打分。
整體而言,我希望這份評比不只是「哪家好吃」,而是幫你在不同情境下(約會、家庭聚餐、朋友小聚、商業午餐)都能快速找到合適的選擇。畢竟,美食不只是味覺的滿足,更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段,從火鍋、燒肉到中式料理與早午餐,每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單,橫跨平價、創意、高級各路風格。
一頭牛日式燒肉|炭香濃郁的和牛饗宴,約會聚餐首選
走在公益路上,很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面,搭配昏黃燈光與暖色調的內裝,讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大,但桌距規劃得宜,每桌皆設有獨立排煙設備,烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂,絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網,讓人完全不用分心。整場用餐過程就像一場表演,從視覺、嗅覺到味覺都被滿足。 綜合評分
地址:408臺中市南屯區公益路二段162號電話:04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」,更像是一場五感盛宴。從進門那一刻到最後一道甜點,都能感受到他們對細節的用心。 TANG Zhan 湯棧|文青系火鍋代表,麻香湯底與視覺美感並重
在公益路這條美食戰線上,TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址:408臺中市南屯區公益路二段248號電話:04-22580617 官網:https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度,又結合現代風格與細節服務,讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店,湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店|明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂,那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主,陽光灑進室內,讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧,建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味,選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口,米芯保留微Q口感;而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香,口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹,無論是一個人帶電腦工作、或朋友聚餐,都能找到舒服角落。餐點上桌速度穩定,服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」,很適合想遠離忙碌日常的人。 綜合評分
地址:40861臺中市南屯區公益路二段18號電話:04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇,而是以「剛剛好」的份量與風味,陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店,NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物|平價卻用心的湯頭系火鍋,家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上,加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐,但靠著實在的湯頭與親切的服務,默默吸引許多回頭客。每到用餐時間,總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底,湯頭清澈卻不單薄,越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向,桌距寬敞、座位舒適,帶小孩來也不覺擁擠。店員態度親切,補湯、收盤都很勤快,給人一種「被照顧著」的安心感。 綜合評分
地址:403臺中市西區公益路288號電話:0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤,而是用最簡單的湯頭與新鮮食材,傳遞出家常卻不平凡的溫度。 印月餐廳|中式料理的藝術演繹,宴客與家庭聚會首選
說到臺中公益路的中式料理代表,印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名,把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設,每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏,都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法,讓人感受到「被款待」的尊榮感。 綜合評分
地址:408臺中市南屯區公益路二段818號電話:0422511155 小結語印月餐廳是一間「不只吃飯,更像品味生活」的地方。 KoDō 和牛燒肉|極致職人精神,專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗,一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉,以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址:403臺中市西區公益路260號電話:0423220312 官網:https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳,而是一場體驗。 永心鳳茶|在茶香裡用餐的優雅時光,臺味早午餐的新詮釋
走進 永心鳳茶公益店,彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤,無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」,都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和,對茶品介紹詳盡。上餐節奏剛好,不急不徐。 綜合評分
地址:40360臺中市西區公益路68號三樓(勤美誠品)電話:0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓|老饕級江浙功夫菜,穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主,兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址:408臺中市南屯區公益路二段95號電話:0423202322 官網:https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司|低調奢華的無菜單日料,職人手藝詮釋旬味極致
在熱鬧的公益路上,一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase(無菜單料理) 形式,每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘,節奏緩慢但沉穩。 綜合評分
地址:408臺中市南屯區公益路二段25號電話:0423206368 官網:https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂|人氣爆棚的和牛燒肉聖地,肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳,茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐,價格約落在 $700–$1000 間,份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快,整場用餐流程流暢無壓力。 綜合評分
地址:403臺中市西區公益路268號電話:0423281167 官網:https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質+輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後,臺中公益路不只是一條美食街,而是一段生活風景線。 有的餐廳講究細膩與儀式感,像 一頭牛日式燒肉 與 一笈壽司,讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心,像 加分昆布鍋物、永心鳳茶,讓人明白吃飯不只是為了飽足,而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店,則用穩定的品質與熱絡的氛圍,成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店,構成了公益路最動人的縮影 有華麗的,也有溫柔的;有傳統的,也有創新的。 每一家都在自己的風格裡發光,讓人吃到的不只是料理,而是一種生活的溫度與節奏。 對我而言,這不僅是一場美食旅程,更是一趟關於「臺中味道」的回憶之旅。 FAQ:關於臺中公益路美食常見問題Q1:公益路哪一區的餐廳最集中? Q2:需要提前訂位嗎? 最後的話若要用一句話形容這趟美食之旅,我會說: 印月餐廳第一次來要點什麼? 如果你也和我一樣喜歡用味蕾探索一座城市,那就把這篇公益路美食攻略收藏起來吧。TANG Zhan 湯棧過年期間會開門嗎? 無論是約會、慶生、家庭聚餐,或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。印月餐廳公司聚餐適合嗎? 下一餐,不妨從這10家開始。KoDō 和牛燒肉有壽星優惠嗎? 打開手機、約上朋友,讓公益路成為你生活裡最容易抵達的小確幸。一笈壽司平日好排隊嗎? 如果你有私心愛店,也歡迎留言分享,印月餐廳整體值得推薦嗎? 你的推薦,可能讓我下一趟美食旅程變得更精彩。TANG Zhan 湯棧值得專程去嗎? MBARI researchers have described a remarkable new species of nudibranch from the depths of the midnight zone. Nicknamed the “mystery mollusc,” Bathydevius caudactylus swims with a fingered tail, uses a cavernous hood to capture food, and glows with brilliant bioluminescence. Credit: © 2014 MBARI A new glowing nudibranch species is the first known to swim through the ocean’s midnight zone and has unique adaptations for life in this environment. The newly discovered sea slug, Bathydevius caudactylus, or mystery mollusk, inhabits the deep-sea midnight zone, displaying unique adaptations like bioluminescence and a hood for capturing prey. It represents a significant find, potentially having a widespread habitat from the Pacific coast of North America to the Mariana Trench. New Deep-Sea Species MBARI researchers have discovered a remarkable new species of deep-sea sea slug, named Bathydevius caudactylus. This creature, nicknamed the “mystery mollusk,” glides through the ocean’s midnight zone with a large gelatinous hood and a paddle-like tail, emitting brilliant bioluminescence. Today (November 12) the team published a detailed description of the mystery mollusk in the journal Deep-Sea Research Part I. “Thanks to MBARI’s advanced underwater technology, we were able to prepare the most comprehensive description of a deep-sea animal ever made,” said MBARI Senior Scientist Bruce Robison, who led the study. “We’ve invested more than 20 years in understanding the natural history of this fascinating species of nudibranch. Our discovery is a new piece of the puzzle that can help better understand the largest habitat on Earth.” MBARI scientists first encountered the mystery mollusk in February 2000, during a dive with the institute’s remotely operated vehicle (ROV) Tiburon near Monterey Bay, at a depth of 2,614 meters (8,576 feet). Since then, the team has used MBARI’s advanced underwater technology to gather extensive data on the species, ultimately reviewing more than 150 sightings of the mystery mollusk over two decades before publishing their findings. The Unique Biology of the Mystery Mollusk With a voluminous hooded structure at one end, a flat tail fringed with numerous finger-like projections at the other, and colorful internal organs in between, the team initially struggled to place this animal in a group. Because the animal also had a foot like a snail, they nicknamed this the “mystery mollusk.” After gently collecting a specimen, MBARI researchers were able to take a closer look at the animal in the lab. Through detailed investigations of anatomy and genetics, they began to solve the mystery, finally confirming that this incredible animal is a nudibranch. Most nudibranchs, also known as sea slugs, live on the seafloor. Nudibranchs are common in coastal environments—including tide pools, kelp forests, and coral reefs—and a small number of species are known to live on the abyssal seafloor. A few are pelagic and live in open waters near the surface. Adaptations to Deep-Sea Life The mystery mollusk is the first nudibranch known to live in the deep water column. This species lives in the ocean’s midnight zone, an expansive environment of open water 1,000 to 4,000 meters (3,300 to 13,100 feet) below the surface, also known as the bathypelagic zone. The mystery mollusk is currently known to live in the waters offshore of the Pacific coast of North America, with sightings on MBARI expeditions as far north as Oregon and as far south as Southern California. An observation of a similar-looking animal by NOAA researchers in the Mariana Trench in the Western Pacific, suggests the mystery mollusk may have a more widespread distribution. The mystery mollusk has evolved unique solutions to find food, safety, and companions to survive in the midnight zone. Feeding Strategies and Survival Tactics While most sea slugs use a raspy tongue to feed on prey attached to the seafloor, the mystery mollusk uses a cavernous hood to trap crustaceans like a Venus fly trap plant. A number of other unrelated deep-sea species use this feeding strategy, including some jellies, anemones, and tunicates. Mystery mollusks are typically seen in open water far below the surface and far above the seafloor. They move through these waters by flexing their body up and down to swim or simply drifting motionless with the currents. To avoid being eaten, the mystery mollusk hides in plain sight with a transparent body. Rapidly closing the oral hood facilitates a quick escape, similar to the pulse of a jelly’s bell. Defense Mechanisms and Bioluminescence If threatened, the mystery mollusk can light up with bioluminescence to deter and distract hungry predators. On one occasion, researchers observed the animal illuminate and then detach a steadily glowing finger-like projection from the tail, likely serving as a decoy to distract a potential predator. “When we first filmed it glowing with the ROV, everyone in the control room let out a loud ‘Oooooh!’ at the same time. We were all enchanted by the sight,” said MBARI Senior Scientist Steven Haddock. “Only recently have cameras become capable of filming bioluminescence in high-resolution and in full color. MBARI is one of the only places in the world where we have taken this new technology into the deep ocean, allowing us to study the luminous behavior of deep-sea animals in their natural habitat.” Reproduction and Genetic Uniqueness Like other nudibranchs, the mystery mollusk is a hermaphrodite, possessing both male and female sex organs. The mystery mollusk appears to descend to the seafloor to spawn. MBARI researchers observed some animals using their muscular foot to attach to the muddy seafloor in order to release their eggs. Detailed examination of specific gene sequences confirmed that the mystery mollusk is unique enough from other known nudibranchs to merit the creation of a new family, Bathydeviidae. Two shallow-water nudibranchs—the lion’s mane nudibranch (Melibe leonina) and the veiled nudibranch (Tethys fimbria)—use a hood to capture prey; however, this appears to be convergent evolution of a similar feeding method, as the mystery mollusk is only distantly related to these species. In fact, genetics suggests the mystery mollusk may have split off first on its own branch of the nudibranch family tree. Conclusion and Future Implications “What is exciting to me about the mystery mollusk is that it exemplifies how much we are learning as we spend more time in the deep sea, particularly below 2,000 meters. For there to be a relatively large, unique, and glowing animal that is in a previously unknown family really underscores the importance of using new technology to catalog this vast environment. The more we learn about deep-sea communities, the better we will be at ocean decision-making and stewardship,” said Haddock. The mystery mollusk is just one of many fascinating discoveries MBARI has made in the midnight zone. To date, MBARI technology has been used to document more than 250 deep-sea species previously unknown to science. “Deep-sea animals capture the imagination. These are our neighbors that share our blue planet. Each new discovery is an opportunity to raise awareness about the deep sea and inspire the public to protect the amazing animals and environments found deep beneath the surface,” said Robison. Mystery mollusc (Bathydevius caudactylus) fact sheet Common name: Mystery mollusc Scientific name: Bathydevius caudactylus Pronunciation: bath-ee-dee-vee-us caw-dack-till-us Habitat: midwater, in the bathypelagic zone Depth range: 1,013 to 4,009 meters (3,323 to 13,153 feet) Geographic range: currently known from the Northeastern Pacific Ocean, from Oregon to Southern California, but likely more widespread Size: 14.5 centimeters (5.6 inches) (total length) Diet: crustaceans, including mysid shrimp Swimming: Bathydevius caudactylus swims with up-and-down undulations of the entire body, from the hood to the tail. Quickly closing the hood propels the animal backward. Most individuals have been observed in the water column at depths of 1,013 to 3,272 meters (3,323 to 10,735 feet), either swimming slowly or passively drifting. Bathydevius caudactylus is neutrally buoyant and does not sink or rise in the water column when at rest. Feeding: Bathydevius caudactylus uses a gelatinous hood to trap crustaceans. The bowl-shaped hood is highly elastic and may be up to 9 centimeters (3.5 inches) across. Meals are ingested through a funnel-shaped mouth at the back of the hood. Bathydevius caudactylus lacks the raspy tongue-like radula typical of bottom-dwelling nudibranchs and snails. Bathydevius caudactylus feeds on prey rich in nutrients, slowly metabolizing meals that may be few and far between in an environment where food is scarce. Physiology: Researchers measured oxygen consumption of Bathydevius caudactylus with the Midwater Respirometer System developed by MBARI scientists and engineers. Bathydevius caudactylus has a metabolism much lower than that reported in other nudibranchs; in fact, respiration rates are more similar to those MBARI researchers have recorded in deep-sea jellies. The reduced respiration reflects the slower pace of life in the deep water column. Bioluminescence: Researchers filmed bioluminescence from Bathydevius caudactylus in the field and the laboratory. Luminous granules in the animal’s tissues create a “starry” appearance across the animal’s back, including a diffuse glow in the oral hood and throughout the tips of the finger-like dactyls in the tail. Bathydevius caudactylus appears to drop luminescent dactyls as a decoy to distract predators, much like a lizard dropping its tail. The dactyls regenerate, with some Bathydevius caudactylus observed bearing dactyls of different lengths. Bioluminescence is uncommon among nudibranchs and snails, and Bathydevius caudactylus represents an independent evolution of this trait—just the third time bioluminescence has evolved in nudibranchs and the seventh time among gastropods. Reproduction: Bathydevius caudactylus is a hermaphrodite with both male and female reproductive organs. Spawning individuals were observed on the seafloor at depths of 2,269 to 4,009 meters (7,444 to 13,153 feet). Bathydevius caudactylus is a solitary species, however, spawning individuals were occasionally seen in proximity to each other on the seafloor. One specimen collected by MBARI researchers released a ribbon of eggs in the laboratory. Eggs hatched three days later, developing into trochophore larvae with a round body and long hair-like cilia. Etymology: The genus name Bathydevius reflects the “devious” nature of this deep-sea animal that fooled researchers with features unlike those of other known nudibranchs. The species name caudactylus refers to distinctive finger-like projections, or dactyls, on the animal’s tail. Reference: “Discovery and description of a remarkable bathypelagic nudibranch, Bathydevius caudactylus, gen. et. sp. nov.” by Bruce H. Robison and Steven H.D. Haddock, 23 October 2024, Deep Sea Research Part I: Oceanographic Research Papers. DOI: 10.1016/j.dsr.2024.104414 This work was funded as part of the David and Lucile Packard Foundation’s longtime support of MBARI’s work to advance marine science and technology to understand a changing ocean. The skull of Peştera Muierii 1, whose entire genome is now successfully sequenced. Credit: Mattias Jakobsson For the first time, researchers have successfully sequenced the entire genome from the skull of Peştera Muierii 1, a woman who lived in today’s Romania 35,000 years ago. Her high genetic diversity shows that the out of Africa migration was not the great bottleneck in human development but rather this occurred during and after the most recent Ice Age. This is the finding of a new study led by Mattias Jakobsson at Uppsala University that was published in Current Biology. “She is a bit more like modern-day Europeans than the individuals in Europe 5,000 years earlier, but the difference is much less than we had thought. We can see that she is not a direct ancestor of modern Europeans, but she is a predecessor of the hunter-gathers that lived in Europe until the end of the last Ice Age,” says Mattias Jakobsson, professor at the Department of Organismal Biology at Uppsala University and the head of the study. The skull of Peştera Muierii 1. Now researchers have successfully sequenced the entire genome from the skull of Peştera Muierii 1, a woman who lived in today’s Romania 35,000 years ago. Credit: Mattias Jakobsson Very few complete genomes older than 30,000 years have been sequenced. Now that the research team can read the entire genome from Peştera Muierii 1 (see the fact box at the bottom of the article), they can see similarities with modern humans in Europe while also seeing that she is not a direct ancestor. In previous studies, other researchers observed that the shape of her cranium has similarities with both modern humans and Neanderthals. For this reason, they assumed that she had a greater fraction of Neanderthal ancestry than other contemporaries, making her stand out from the norm. But the genetic analysis in the current study shows that she has the same low level of Neanderthal DNA as most other individuals living in her time. Compared with the remains from some individuals who lived 5,000 years earlier, such as Peştera Oase 1, she had only half as much Neanderthal ancestry. The spread of modern humans out of Africa about 80,000 years ago is an important period in human history and is often described as a genetic bottleneck. Populations moved out of Africa and into Asia and Europe. The effects of these migrations can be seen even today. Genetic diversity is lower in populations outside of Africa than in African. That Peştera Muierii 1 has high genetic diversity implies that the greatest loss of genetic diversity occurred during the last Ice Age (which ended about 10,000 years ago) instead of during the out of Africa migration. “This is exciting since it teaches us more about the early population history of Europe. Peştera Muierii 1 has much more genetic diversity than expected for Europe at this time. This shows that genetic variation outside of Africa was considerable until the last Ice Age, and that the Ice Age caused the decrease in diversity in humans outside of Africa.” Mattias Jakobsson, Professor at the Department of Organismal Biology at Uppsala University, Sweden. Credit: David Naylor The researchers were also able to follow the genetic variation in Europe over the last 35,000 years and see a clear decrease in variations during the last Ice Age. The reduced genetic diversity has previously been linked to pathogenic variants in genomes being more common among populations outside of Africa, but this is in dispute. “Access to advanced medical genomics has allowed us to study these ancient remains and even be able to look for genetic diseases. To our surprise, we did not find any differences during the last 35,000 years, even though some individuals alive during the Ice Age had low genetic diversity. Now we have accessed everything possible from these remains. Peştera Muierii 1 is important from a cultural history perspective and will certainly remain interesting for researchers within other areas, but from a genetic perspective, all the data is now available.” Fact Peştera Muierii Peştera Muierii 1 is the name given to one of the three individuals whose remains were found in a cave of the same name. Peştera Muierii (roughly translates to women’s cave) is the name of a cave system in Baia de Fier in southern Romania. It is best known for the remains of cave bears and for the 1950s discovery of skulls and other skeletal parts from three females that lived about 35,000 to 40,000 years ago. Reference: “Genome of Peştera Muierii skull shows high diversity and low mutational load in pre-glacial Europe” by Emma Svensson, Torsten Günther, Alexander Hoischen, Montserrat Hervella, Arielle R. Munters, Mihai Ioana, Florin Ridiche, Hanna Edlund, Rosanne C. van Deuren, Andrei Soficaru, Concepción de-la-Rua, Mihai G. Netea and Mattias Jakobsson, 18 May 2021, Current Biology. DOI: 10.1016/j.cub.2021.04.045 Scientists showed that the bacterium Pseudomonas aeruginosa communicate using chemical signals analogous to radio signals in order to help cells join together and form communities. Credit: Janice Haney Carr/CDC UCLA researchers discovered that bacteria communicate in biofilms using oscillating chemical signals, specifically c-di-GMP, influencing colony formation. This insight could lead to better control of biofilms in various applications, including health and environmental technologies. The thought of bacteria joining together to form a socially organized community capable of cooperation, competition, and sophisticated communication might at first seem like the stuff of science fiction — or just plain gross. But biofilm communities have important implications for human health, from causing illness to aiding digestion. And they play a role in a range of emerging technologies meant to protect the environment and generate clean energy. New Insights Into Bacterial Communication New UCLA-led research could give scientists insights that will help them cultivate useful microbes or clear dangerous ones from surfaces where biofilms have formed — including on tissues and organs in the human body. The study, published in the Proceedings of the National Academy of Sciences, describes how, when biofilms form, bacteria communicate with their descendants using a chemical signal analogous to radio transmissions. The investigators showed that concentration levels of a messenger molecule called cyclic diguanylate, or c-di-GMP, can increase and decrease in well-defined patterns over time, and across generations of bacteria. Bacteria cells employ those chemical signal waves, the study found, to encode information for their descendants that helps coordinate colony formation. In that phenomenon, whether a given cell attaches to a surface is influenced by the specific shape of those oscillations — much like the way information is stored in AM and FM radio waves. Controlling Biofilm Formation “Because these oscillations orchestrate what the entire lineage does, a large number of cells are controlled at the same time with these signals,” said corresponding author Gerard Wong, a professor of bioengineering at the UCLA Samueli School of Engineering and of chemistry and biochemistry at the UCLA College, and a member of the California NanoSystems Institute at UCLA. “That means we potentially have a new knob to control or fine-tune biofilm formation, which works like mass communications for bacteria.” Stopping the formation of biofilms could be lifesaving in certain scenarios, such as countering the infections coating the lining of the lungs in people with cystic fibrosis. In other situations, enhancing the ability to cultivate biofilms would be helpful — fortifying colonies of “good” bacteria in the human gut to help with digestion, for example, or to protect people from disease-causing microbes. And scientists and engineers, including several at UCLA, are working to develop bacterial biofilms that can break down plastic, eat industrial waste or even generate electricity in a fuel cell. Expanding the Understanding of Biofilm Formation The study adds new dimensions to the scientific understanding of the mechanisms that lead to biofilms. The current paradigm, established over the last 20 years or so, holds that when a bacterium senses a surface, that cell begins producing c-di-GMP, which in turn causes the bacterium to attach to the surface. Indeed, biofilm cells generally have higher levels of c-di-GMP than bacterial cells that move around a lot. Biofilm research focusing on bacteria’s ability to communicate from one generation to another was pioneered by first author Calvin Lee, a UCLA postdoctoral researcher, along with Wong and their teammates, in a 2018 publication. In the current study, the team elucidates how bacteria communicate about the existence of a surface using c-di-GMP signals: Signal waves of different heights and different frequencies can be transmitted by a cell to its descendants. Those chemical signals are analogous to, respectively, AM radio — amplitude modulation, which encodes a given signal based on the amplitude, or height, of a radio wave — and FM radio — frequency modulation, which encodes signals by the number of oscillations in the wave over a given period of time. New Techniques to Analyze Biofilm Formation With analysis techniques typically used in big data and artificial intelligence, the researchers identified three important factors that control the formation of biofilm: average levels of c-di-GMP, the frequency of oscillations in c-di-GMP levels, and the degree of cell movement on the surface where the biofilm is forming. “The existing paradigm is that one input produces one output, with increasing levels of the signal leading to biofilm formation,” Lee said. “We’re proposing that multiple inputs eventually lead to that same output, and that bacteria can leave long-lasting messages for their offspring. You need to look at more things in order to get the full picture.” Reference: “Broadcasting of amplitude- and frequency-modulated c-di-GMP signals facilitates cooperative surface commitment in bacterial lineages” by Calvin K. Lee, William C. Schmidt, Shanice S. Webster, Jonathan W. Chen, George A. O’Toole and Gerard C. L. Wong, 25 January 2022, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2112226119 Other co-authors of the study are graduate students William Schmidt and Jonathan Chen of UCLA, and graduate student Shanice Webster and professor George O’Toole of Dartmouth College. The study was supported by the National Institutes of Health, the Army Research Office and the National Science Foundation. RRG455KLJIEVEWWF |
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