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NINI 尼尼台中店有什麼隱藏版必點嗎?》台中公益路聚餐推薦|10大類型餐廳評比 |
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身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人,臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」,從精緻西餐到創意火鍋,從日式丼飯到義式早午餐,每走幾步,就會有完全不同的特色料理餐廳。 這次我特別花了一整個月,實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店,也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準,整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你,找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型,從高質感牛排館到巷弄系早午餐,每一間都有自己獨特的風格。為了讓整體比較更客觀,我依照以下四大面向進行評比,並搭配實際用餐體驗來打分。
整體而言,我希望這份評比不只是「哪家好吃」,而是幫你在不同情境下(約會、家庭聚餐、朋友小聚、商業午餐)都能快速找到合適的選擇。畢竟,美食不只是味覺的滿足,更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段,從火鍋、燒肉到中式料理與早午餐,每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單,橫跨平價、創意、高級各路風格。
一頭牛日式燒肉|炭香濃郁的和牛饗宴,約會聚餐首選
走在公益路上,很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面,搭配昏黃燈光與暖色調的內裝,讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大,但桌距規劃得宜,每桌皆設有獨立排煙設備,烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂,絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網,讓人完全不用分心。整場用餐過程就像一場表演,從視覺、嗅覺到味覺都被滿足。 綜合評分
地址:408臺中市南屯區公益路二段162號電話:04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」,更像是一場五感盛宴。從進門那一刻到最後一道甜點,都能感受到他們對細節的用心。 TANG Zhan 湯棧|文青系火鍋代表,麻香湯底與視覺美感並重
在公益路這條美食戰線上,TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址:408臺中市南屯區公益路二段248號電話:04-22580617 官網:https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度,又結合現代風格與細節服務,讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店,湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店|明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂,那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主,陽光灑進室內,讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧,建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味,選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口,米芯保留微Q口感;而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香,口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹,無論是一個人帶電腦工作、或朋友聚餐,都能找到舒服角落。餐點上桌速度穩定,服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」,很適合想遠離忙碌日常的人。 綜合評分
地址:40861臺中市南屯區公益路二段18號電話:04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇,而是以「剛剛好」的份量與風味,陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店,NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物|平價卻用心的湯頭系火鍋,家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上,加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐,但靠著實在的湯頭與親切的服務,默默吸引許多回頭客。每到用餐時間,總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底,湯頭清澈卻不單薄,越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向,桌距寬敞、座位舒適,帶小孩來也不覺擁擠。店員態度親切,補湯、收盤都很勤快,給人一種「被照顧著」的安心感。 綜合評分
地址:403臺中市西區公益路288號電話:0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤,而是用最簡單的湯頭與新鮮食材,傳遞出家常卻不平凡的溫度。 印月餐廳|中式料理的藝術演繹,宴客與家庭聚會首選
說到臺中公益路的中式料理代表,印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名,把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設,每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏,都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法,讓人感受到「被款待」的尊榮感。 綜合評分
地址:408臺中市南屯區公益路二段818號電話:0422511155 小結語印月餐廳是一間「不只吃飯,更像品味生活」的地方。 KoDō 和牛燒肉|極致職人精神,專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗,一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉,以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址:403臺中市西區公益路260號電話:0423220312 官網:https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳,而是一場體驗。 永心鳳茶|在茶香裡用餐的優雅時光,臺味早午餐的新詮釋
走進 永心鳳茶公益店,彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤,無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」,都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和,對茶品介紹詳盡。上餐節奏剛好,不急不徐。 綜合評分
地址:40360臺中市西區公益路68號三樓(勤美誠品)電話:0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓|老饕級江浙功夫菜,穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主,兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址:408臺中市南屯區公益路二段95號電話:0423202322 官網:https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司|低調奢華的無菜單日料,職人手藝詮釋旬味極致
在熱鬧的公益路上,一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase(無菜單料理) 形式,每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘,節奏緩慢但沉穩。 綜合評分
地址:408臺中市南屯區公益路二段25號電話:0423206368 官網:https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂|人氣爆棚的和牛燒肉聖地,肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳,茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐,價格約落在 $700–$1000 間,份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快,整場用餐流程流暢無壓力。 綜合評分
地址:403臺中市西區公益路268號電話:0423281167 官網:https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質+輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後,臺中公益路不只是一條美食街,而是一段生活風景線。 有的餐廳講究細膩與儀式感,像 一頭牛日式燒肉 與 一笈壽司,讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心,像 加分昆布鍋物、永心鳳茶,讓人明白吃飯不只是為了飽足,而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店,則用穩定的品質與熱絡的氛圍,成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店,構成了公益路最動人的縮影 有華麗的,也有溫柔的;有傳統的,也有創新的。 每一家都在自己的風格裡發光,讓人吃到的不只是料理,而是一種生活的溫度與節奏。 對我而言,這不僅是一場美食旅程,更是一趟關於「臺中味道」的回憶之旅。 FAQ:關於臺中公益路美食常見問題Q1:公益路哪一區的餐廳最集中? Q2:需要提前訂位嗎? 最後的話若要用一句話形容這趟美食之旅,我會說: 茶六燒肉堂真的有那麼好吃嗎? 如果你也和我一樣喜歡用味蕾探索一座城市,那就把這篇公益路美食攻略收藏起來吧。KoDō 和牛燒肉過年期間會開門嗎? 無論是約會、慶生、家庭聚餐,或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。永心鳳茶整體值得推薦嗎? 下一餐,不妨從這10家開始。KoDō 和牛燒肉價位會不會太高? 打開手機、約上朋友,讓公益路成為你生活裡最容易抵達的小確幸。NINI 尼尼臺中店值得專程去嗎? 如果你有私心愛店,也歡迎留言分享,一笈壽司適合辦部門小聚嗎? 你的推薦,可能讓我下一趟美食旅程變得更精彩。NINI 尼尼臺中店大型聚餐空間夠不夠? Scientists have made significant breakthroughs in understanding brain function using the nematode C. elegans. The research, employing optogenetics and connectomics, offers new insights into neural communication and challenges traditional models, enhancing our understanding of complex neural networks. A new study investigates the transfer of information between neurons. Do we really know how the brain works? In recent decades, significant advancements have been made in comprehending the intricate workings of the brain. Researchers have gained extensive knowledge about the cellular neurobiology of the brain and have uncovered a lot about its neural networks and the elements constituting these connections. Despite this, a whole host of important questions remain unanswered and, consequently, the brain continues to be one of science’s great, tantalizing mysteries. Perhaps one of the most nagging of these questions revolves around our understanding of the brain as a system. Scientists are still largely in the dark about how the brain functions as a network of interacting components, about how all the neural components cooperate, and especially, how information is processed between and among this complex network of neurons. Revolutionary Research on a Simple Organism: The C. elegans Worm Now, however, a team of neuroscientists and physicists at Princeton University are helping to shine a clarifying light on how information flows in the brain by studying, of all things, the brain of a very small but ubiquitous worm known as Caenorhabditis elegans. The details of the experiment are chronicled in a recent issue of Nature. The team consisted of Francesco Randi, Sophie Dvali, and Anuj Sharma and was led by Andrew Leifer, a neuroscientist and physicist. “Brains are exciting and mysterious,” said Leifer. “Our team is interested in the question of how collections of neurons process information and generate action.” Video shows measurements of neural activity in the worm’s head as individual neurons are optically stimulated one at a time. The neuron in the crosshairs is stimulated when the words “Stimulated” appear. When neurons become active they appear dark red in this visualization. The video is sped up 4x. Credit: Francesco Randi, Princeton University Interest in this question has broad implications, Leifer added. Understanding how a network of neurons works is a specific example of a broader class of questions in biological physics, namely, how collective phenomena emerge from networks of interacting cells and molecules. This area of research has implications for many topics relevant to biological physics as well as contemporary, cutting-edge technologies, such as artificial intelligence. The first step in answering the question of how information is processed through a network of interacting neurons required that Leifer and his team find a suitable organism that could easily be manipulated in the lab. This turned out to be C. elegans, an unsegmented, non-parasitic nematode, or roundworm, that has been studied by scientists for decades and is considered a “genetically model organism.” Model organisms are commonly used in the laboratory to help scientists understand biological processes because their anatomy, genetics, and behaviors are well understood. Innovative Techniques in Brain Mapping and Optogenetics The worm is approximately one millimeter in length and is found in many bacteria-rich environments. Especially pertinent to the current study is the fact that the organism has a nervous system of only 302 neurons in its entire body, 188 of which reside in its brain. “By contrast, a human brain has hundreds of billions of neurons,” said Leifer. “So, these worms are much simpler to study. In fact, these worms are excellent for experimentation because they strike just the right balance between simplicity and complexity.” Importantly, added Leifer, C. elegans was the first organism to have its brain wiring fully “mapped.” This means that scientists have compiled a comprehensive diagram, or “map,” of all its neurons and synapses—the places where neurons physically connect and communicate with other neurons. This field of endeavor is called “connectomics,” in the parlance of neuroscience, and a diagram of a comprehensive map of neural connections in the brain of an organism is known as a “connectome.” One of the main goals of connectomics is finding out specific nerve connections responsible for particular behaviors. Neurons in the microscopic worm C. elegans. The worm’s neurons have been genetically engineered to be color-coded by their cell type. The names of each neuron are shown in yellow. Credit: Francesco Randi, Princeton University An additional advantage in using C. elegans in laboratory experiments is that the worm is transparent, and, in certain cases, its tissue has been genetically engineered to be light-sensitive. This area of research is known as “optogenetics” and it has revolutionized many aspects of experimentation in biological neuroscience. Instead of the more conventional system of using an electrode to deliver a current into a neuron and thereby stimulate a response, the optogenetic technique involves using light-sensitive proteins from certain organisms and implanting those cells in another organism so that researchers can control an organism’s behavior or responses using light signals. Similarly, other proteins can be used to light up and report when one neuron signals to another. This means two important things for laboratory experimentation: that an organism will respond to the presence of light, and that a neuron, once it receives a signal from another neuron, will “light up.” This has allowed researchers to study the interaction of neurons visually. “What is really powerful about this tool is that you can literally turn neurons on and watch them signal in real-time,” said Leifer. “In essence, we can convert the problem of measuring and manipulating neural activity to one of collecting and delivering the right light to the right place at the right time.” These optical tools allowed Leifer’s team to begin the painstaking task of understanding how information flows through the worm’s brain. The goal was to understand how signals flow directly through the worm’s entire brain, so each neuron had to be measured. This involved isolating one neuron at a time, shining a light on it, so that it was “activated,” and then observing how the other neurons responded. “For this experiment, we went one neuron at a time through the entire brain, activating or perturbing each neuron and then watching the whole network respond,” said Leifer. “This way, we were able to map out how signals flowed through the network.” “This was an approach that had never been done before at the scale of an entire brain,” added Leifer. In all, Leifer and his team performed nearly 10,000 stimulus events by measuring over 23,000 pairs of neurons and their responses, a task that took seven years from conception to completion. Challenging Established Models and Introducing New Insights The research conducted by Leifer and his team is thus far the most comprehensive description of how signals flow through the brain. For scientists who study C. elegans, the researchers provided a lot of information on how specific signals work in the worm’s brain, and it is hoped that this research will provide a plethora of new information that will help advance basic research. An equally important finding was that a number of the empirical observations Leifer and his team made during the experiment often contradicted the predictions of worm behavior based on mathematical models derived from the worm’s connectome map. “We concluded that, in many cases, many molecular details that you can’t see from the wiring diagram are actually very important for predicting how the network should respond,” said Leifer. The researchers suggest that there is a form of signaling—part of the “molecular details that you can’t see”—that does not progress along neural wires. Leifer and his group characterized these as “wireless signals.” Although wireless signaling is well known among neuroscientists, it has largely been underappreciated for studying neural dynamics because it had often thought to be a process that occurs very slowly. Wireless signaling is a form of signaling by which a neuron releases molecules, called neuropeptides, into the extracellular space, or “extracellular milieu,” between neurons. These chemicals diffuse and bind to other neurons even if there is no physical connection between them. Finally, the researchers believe that an important impact of their work is that it allows other neuroscientists studying this and similar phenomena to develop better models with which to understand the brain as a system. “With our research, we provided a very important piece of the puzzle that was missing,” said Leifer. Reference: “Neural signal propagation atlas of Caenorhabditis elegans” by Francesco Randi, Anuj K. Sharma, Sophie Dvali and Andrew M. Leifer, 1 November 2023, Nature. DOI: 10.1038/s41586-023-06683-4 This work was primarily supported by the National Institute of Health New Innovator Award, a National Science Foundation CAREER Award, and an award from the Simons Foundation. Funding was also received from an NSF Physics Frontier Center grant that supports Princeton University’s Center for Physics of Biological Function. Artificial light on coral reefs leads to increased predator activity and changes in fish behavior, with potential resilience improvements through reduced lighting. Credit: Emma Weschke New research using underwater infrared cameras reveals that artificial light disrupts the nocturnal activities of coral reef communities, causing behavioral changes in fish. Predatory fish are drawn to these artificially lit areas, disrupting the natural ecosystem. Solutions such as reducing light pollution could quickly improve the resilience of coral reefs. Impact of Light Pollution on Coral Reefs Artificial light disrupts the natural behavior of coral reef fish, waking sleeping species and attracting predators, according to groundbreaking research using underwater infrared cameras. The study, published today (December 18) in Global Change Biology, involved an international team of scientists from the UK, France, French Polynesia, and Chile. It marks the first large-scale investigation into how light pollution affects the nocturnal dynamics of coral reef ecosystems. Emma Weschke deploying infrared cameras. Credit: Jules Schligler Behavioral Changes in Marine Life Dr. Emma Weschke, lead author from the University of Bristol’s School of Biological Sciences, explained: “When the sun sets, coral reefs undergo a dramatic transformation. The vibrant fish we see in the day retreat to sleep among the corals and elusive nocturnal species emerge from caves and cervices in pursuit of prey.” Senior author, Professor Andy Radford, also from Bristol, added: “The night usually brings a veil of darkness that allows marine life to hide from nocturnal predators. But artificial light generated by human activities exposes coral reef inhabitants to unexpected danger.” Still from video of reef at night exposed to artificial light. Credit: Emma Weschke Technological Advances in Research Using purpose-built underwater infrared night-vision cameras, the scientists could film the reef at night without interfering with fish behavior. This is because fish cannot see in infrared. A larger number of fish species were present on artificially illuminated reefs at night compared to control sites with no artificial light. Further investigation revealed these species were predatory fish—feeding on the zooplankton, small fish, and invertebrates. Dr. Weschke said: “Many of the species detected on artificially lit reefs were not nocturnal fish, but those that are only usually active during the day. Finding that light pollution can cause fish to stay awake later than usual is concerning because sleep—like for us—is likely essential for regenerating energy and maintaining fitness.” Professor Radford explained: “Artificial light makes it much easier for predators to locate and capture prey, reducing their foraging effort. Which is why we think that greater numbers are being attracted to artificially illuminated coral reefs at night.” Long-Term Effects and Solutions The changes observed in the nightlife on the reef were observed after an average of 25 consecutive nights exposure to artificial light. Only a few nights of exposure were not long enough to elicit any noticeable changes in fish communities compared to controls. “This is positive news as it suggests that there could be low-cost solutions that are quick to implement,” said co-author Professor Steve Simpson, also of Bristol’s School of Biological Sciences. “Reducing the impacts of artificial light could help build resilience on valuable coral reefs.” Dr. Weschke added: “Unlike greenhouse gasses and plastics, artificial light is a pollutant that doesn’t leave a residue when switched off. “Limiting artificial light in both its intensity and duration, prioritizing it for essential needs and reducing aesthetic use, will help reestablish naturally dark nights that marine ecosystems evolved with.” Reference: “Artificial Light Increases Nighttime Prevalence of Predatory Fishes, Altering Community Composition on Coral Reefs” by Emma Weschke, Jules Schligler, Isla Hely, Thibaut Roost, Jo-Ann Schies, Ben Williams, Bartosz Dworzanski, Suzanne C. Mills, Ricardo Beldade, Stephen D. Simpson and Andrew N. Radford, 18 December 2024, Global Change Biology. DOI: 10.1111/gcb.70002 The work was conducted by researchers from the University of Bristol, UK, Centre de Recherches Insulaires et Observatoire de l’Environnement (CRIOBE), French Polynesia and Pontificia Universidad Católica de Chile. A team at UCLA has created an AI model that uses epigenetic factors to accurately predict patient outcomes in different cancer types. This innovative approach offers improved predictions over traditional methods and highlights the importance of epigenetics in cancer treatment and progression. UCLA researchers found certain genes encoding epigenetic factors in tumors have a predictive association with clinical outcome across cancer types. Investigators from the UCLA Health Jonsson Comprehensive Cancer Center have developed an artificial intelligence (AI) model based on epigenetic factors that is able to predict patient outcomes successfully across multiple cancer types. Epigenetic Factors in Cancer Prediction The researchers found that by examining the gene expression patterns of epigenetic factors — factors that influence how genes are turned on or off — in tumors, they could categorize them into distinct groups to predict patient outcomes across various cancer types better than traditional measures like cancer grade and stage. These findings, described today (November 15) in Communications Biology, also lay the groundwork for developing targeted therapies aimed at regulating epigenetic factors in cancer therapy, such as histone acetyltransferases and SWI/SNF chromatin remodelers. Understanding Cancer Beyond Genetic Mutations “Traditionally, cancer has been viewed as primarily a result of genetic mutations within oncogenes or tumor suppressors,” said co-senior author Hilary Coller, professor of molecular, cell, and developmental biology and a member of the UCLA Health Jonsson Comprehensive Cancer Center and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. “However, the emergence of advanced next-generation sequencing technologies has made more people realize that the state of the chromatin and the levels of epigenetic factors that maintain this state are important for cancer and cancer progression. There are different aspects of the state of the chromatin — like whether the histone proteins are modified, or whether the nucleic acid bases of the DNA contain extra methyl groups — that can affect cancer outcomes. Understanding these differences between tumors could help us learn more about why some patients respond differently to treatments and why their outcomes vary.” While previous studies have shown that mutations in the genes that encode epigenetic factors can affect an individual’s cancer susceptibility, little is known about how the levels of these factors impact cancer progression. This knowledge gap is crucial in fully understanding how epigenetics affects patient outcomes, noted Coller. Epigenetic Patterns and Clinical Outcomes To see if there was a relationship between epigenetic patterns and clinical outcomes, the researchers analyzed the expression patterns of 720 epigenetic factors to classify tumors from 24 different cancer types into distinct clusters. Out of the 24 adult cancer types, the team found that for 10 of the cancers, the clusters were associated with significant differences in patient outcomes, including progression-free survival, disease-specific survival, and overall survival. This was especially true for adrenocortical carcinoma, kidney renal clear cell carcinoma, brain lower grade glioma, liver hepatocellular carcinoma and lung adenocarcinoma, where the differences were significant for all the survival measurements. The clusters with poor outcomes tended to have higher cancer stage, larger tumor size, or more severe spread indicators. “We saw that the prognostic efficacy of an epigenetic factor was dependent on the tissue-of-origin of the cancer type,” said Mithun Mitra, co-senior author of the study and an associate project scientist in the Coller laboratory. “We even saw this link in the few pediatric cancer types we analyzed. This may be helpful in deciding the cancer-specific relevance of therapeutically targeting these factors.” AI Model for Predicting Patient Outcomes The team then used epigenetic factor gene expression levels to train and test an AI model to predict patient outcomes. This model was specifically designed to predict what might happen for the five cancer types that had significant differences in survival measurements. The scientists found the model could successfully divide patients with these five cancer types into two groups: one with a significantly higher chance of better outcomes and another with a higher chance of poorer outcomes. They also saw that the genes that were most crucial for the AI model had a significant overlap with the cluster-defining signature genes. Potential for Broader Application “The pan-cancer AI model is trained and tested on the adult patients from the TCGA cohort and it would be good to test this on other independent datasets to explore its broad applicability,” said Mitra. “Similar epigenetic factor-based models could be generated for pediatric cancers to see what factors influence the decision-making process compared to the models built on adult cancers.” “Our research helps provide a roadmap for similar AI models that can be generated through publicly-available lists of prognostic epigenetic factors,” said the study’s first author, Michael Cheng, a graduate student in the Bioinformatics Interdepartmental Program at UCLA. “The roadmap demonstrates how to identify certain influential factors in different types of cancer and contains exciting potential for predicting specific targets for cancer treatment.” Reference: “Pan-cancer landscape of epigenetic factor expression predicts tumor outcome” by Michael W. Cheng, Mithun Mitra and Hilary A. Coller, 16 November 2023, Communications Biology. DOI: 10.1038/s42003-023-05459-w The study was funded in part by grants from the National Cancer Institute, Cancer Research Institute, Melanoma Research Alliance, Melanoma Research Foundation, National Institutes of Health, and the UCLA Spore in Prostate Cancer. RRG455KLJIEVEWWF |
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