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文章數：80 |
 三希樓肉質如何？》台中公益路大揭密｜10家美食名店全盤解析 |
| 知識學習｜考試升學 2026/04/20 15:38:28 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。 這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。 評比標準與整理方向
這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。
整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。 10間臺中公益路餐廳評比懶人包公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。
一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選
走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。 餐點特色
一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。 用餐體驗整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。 綜合評分
地址：408臺中市南屯區公益路二段162號電話：04-23206800 小結語一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。 TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重
在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。 餐點特色
湯棧最有名的當然是它的「麻香鍋」。 用餐體驗整體氛圍比一般火鍋店更有質感。 綜合評分
地址：408臺中市南屯區公益路二段248號電話：04-22580617 官網：https://www.facebook.com/TangZhan.tw/ 小結語TANG Zhan 湯棧 把傳統火鍋做出新的樣貌保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。 NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂
如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。 餐點特色
NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。 用餐體驗店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。 綜合評分
地址：40861臺中市南屯區公益路二段18號電話：04-23288498 小結語NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。 加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇
在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。 餐點特色
主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。 用餐體驗整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。 綜合評分
地址：403臺中市西區公益路288號電話：0910855180 小結語加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。 印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選
說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。 餐點特色
印月最令人印象深刻的是他們將傳統中菜融入創意手法。 用餐體驗服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。 綜合評分
地址：408臺中市南屯區公益路二段818號電話：0422511155 小結語印月餐廳是一間「不只吃飯，更像品味生活」的地方。 KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生
若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。 餐點特色
這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。 用餐體驗KoDō 的最大特色是「儀式感」。 綜合評分
地址：403臺中市西區公益路260號電話：0423220312 官網：https://www.facebook.com/kodo2018/ 小結語KoDō 和牛燒肉不是日常餐廳，而是一場體驗。 永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋
走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。 餐點特色
永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。 用餐體驗店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。 綜合評分
地址：40360臺中市西區公益路68號三樓(勤美誠品)電話：0423221118 小結語永心鳳茶讓人重新定義「臺味」。 三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴
位於公益路上的 三希樓 是許多臺中老饕的口袋名單。 餐點特色
三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。 用餐體驗三希樓的服務給人一種老派但貼心的感覺。 綜合評分
地址：408臺中市南屯區公益路二段95號電話：0423202322 官網：https://www.sanxilou.com.tw/ 小結語三希樓是一間「吃得出功夫」的餐廳。 一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致
在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。 餐點特色
一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。 用餐體驗整場用餐約90分鐘，節奏緩慢但沉穩。 綜合評分
地址：408臺中市南屯區公益路二段25號電話：0423206368 官網：https://www.facebook.com/YIJI.sushi/ 小結語一笈壽司是一間真正讓人「放慢呼吸」的餐廳。 茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分
若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。 餐點特色
茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。 用餐體驗茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。 綜合評分
地址：403臺中市西區公益路268號電話：0423281167 官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA 小結語茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。 吃完10家公益路餐廳後的心得與結語吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。 有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好 有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。 而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。 這十家店，構成了公益路最動人的縮影 有華麗的，也有溫柔的；有傳統的，也有創新的。 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。 對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。 FAQ：關於臺中公益路美食常見問題Q1：公益路哪一區的餐廳最集中？ Q2：需要提前訂位嗎？ 最後的話若要用一句話形容這趟美食之旅，我會說： 一頭牛日式燒肉值得排隊嗎？ 如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。一笈壽司尾牙拍照效果好嗎？ 無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。茶六燒肉堂過年期間會開門嗎？ 下一餐，不妨從這10家開始。茶六燒肉堂會太油嗎？ 打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。永心鳳茶春酒菜色豐富嗎？ 如果你有私心愛店，也歡迎留言分享，一頭牛日式燒肉婚前派對適合嗎？ 你的推薦，可能讓我下一趟美食旅程變得更精彩。印月餐廳有什麼推薦搭配？ Advances in research have enabled the creation of a near-complete primate timetree, offering new insights into primate evolution. Credit: SciTechDaily.com Recent scientific efforts have advanced the development of a comprehensive primate evolutionary timetree, filling significant gaps in our understanding of primate biodiversity and evolutionary history. The primate order includes not only humanity’s closest relatives—the seven great apes—but also more than 450 species of monkeys, lemurs, lorises, and galagos. This group is remarkably diverse, ranging from 400-pound gorillas to tiny mouse lemurs (Microcebus) that weigh just one ounce. Primates display some of the most fascinating behaviors in the animal kingdom: chimpanzees use sticks to ‘fish’ for termites in hollow logs, while orangutans fashion leaf gloves to handle prickly durian fruit. Despite being among the most thoroughly studied animals on Earth, primates still lack a complete molecular phylogenetic tree—a comprehensive evolutionary map detailing when different species emerged and how they are related. A robust phylogenetic tree would use genetic data to trace the timing of species’ appearances and identify their closest evolutionary relatives. Currently, the largest molecular timetree for primates includes just over 200 species. Even the most extensive synthetic timetree, based on more than 4,000 published studies, covers only about 400 species, leaving roughly one-fifth of the primate evolutionary tree unresolved. Timetree of 455 species of primates. Images from phylopic.org. Credit: Craig et al., 2024. The Significance of Complete Evolutionary Trees The value of timed evolutionary trees containing every species of a given lineage cannot be understated. While such trees are intrinsically compelling, as they capture the evolutionary history that gave us our present biodiversity, they also form essential foundations for many types of future work. For example, taxonomic and systematic efforts to catalog species rely on them to identify new lineages. Studies of the rate of evolution and its possible correlates like climate and geological changes are fundamentally tied to their underlying phylogenies. Fields like biogeography, phylogeography, and historical ecology, which use timetrees to investigate spatial or ecological patterns, would be impossible without a phylogeny. And, as we watch global biodiversity slip away amid ongoing extinction events, phylogenies are essential tools in identifying conservation priorities and assessing the impacts of our efforts to preserve species. Rarity of Comprehensive Phylogenies Since comprehensive molecular phylogenies are valuable tools, it may be a surprise to learn that they tend to be rare. The NCBI taxonomy database currently includes molecular sequences for almost 500,000 species, while The TimeTree of Life, the largest database of published timed phylogenies, includes about 150,000 species. In exploring the collection of studies included in the database, we discovered that most phylogenies tend to be small, encompassing only 25 species on average. These trees are the efforts of people dedicated to studying groups of closely related organisms like genera or families who prioritize resolution in their study system over broader scale. Thus, the need for a complete tree of life will only be met if we can find a way to bring together these efforts. Innovations in Timetree Development While large, fully timed trees with molecular sequence data for all species are rare, we have found that the materials to build them are common. For one, untimed phylogenies greatly outnumber timed phylogenies in the literature, even among papers published in the last ten years. With only one or a few calibrations, they can become valuable components of the global timetree of life. Even though many species have never been incorporated into a molecular phylogeny, there is often corresponding molecular data deposited in repositories like NCBI GenBank, where DNA sequence information is freely accessible to researchers. These two sources of data represent a fantastic opportunity to build comprehensive timetrees. Realizing a Comprehensive Primate Timetree Over the course of several publications, we have developed a supertree building approach entailing the assembly of all published, timed phylogenies including species of interest; a search for untimed trees including any remaining species followed by novel timing using literature consensus secondary calibrations; and finally, the assembly of de novo alignments and ultimately timed phylogenies based on publicly available data. In our most recent effort, this search uncovered enough data to build a new synthetic supertree of 455 primates, 98% of all those present in the NCBI taxonomy, and 55 more than were already present in TimeTree. Our new timetree represents the most complete description of the evolutionary relationships among primates to date. Completing the TimeTree of Life This effort has demonstrated that while the evolutionary history of even some of the most charismatic species on Earth has remained incompletely understood, we have the tools to fill much of this gap in knowledge. We envision our research protocol as an accessible and, ultimately, extremely valuable tool in our efforts to understand evolution. Complete timetrees are a foundational resource in many fields, and we have discovered that they can often be built from existing data. Furthermore, such complete timetrees allow us to test hypotheses we could not otherwise. For example, in the present study, we tested whether the numbers of species in different primate clades could better be explained by unique speciation rates, with some primate lineages generating new species much faster than others, or whether the best explanation was simply time, with all lineages making new species at about the same rate, and older lineages accruing more species over time. What we found was that the major groups of primates did in fact all share relatively similar rates of speciation, and that their age was therefore a better predictor of their species richness. This analysis would be quite problematic if we were missing many species or dates in our timetree, so it serves as a perfect example of the utility of large, complete timetrees. Reference: “Completing a molecular timetree of primates” by Jack M. Craig, S. Blair Hedges and Sudhir Kumar, 24 October 2024, Frontiers in Bioinformatics. DOI: 10.3389/fbinf.2024.1495417 When outfitted with a groundbreaking “laboratory in a can” to sample environmental DNA (eDNA), nimble robots like MBARI’s long-range autonomous underwater vehicle (LRAUV) can expand the monitoring of ocean health. Credit: © 2021 MBARI/Monterey Bay Aquarium Autonomous technology uses eDNA to survey biodiversity. In a major step forward for monitoring the biodiversity of marine systems, a new research study published on May 17, 2022, in the journal Environmental DNA details how Monterey Bay Aquarium Research Institute (MBARI) researchers are using autonomous underwater robots to sample environmental DNA (eDNA). eDNA allows scientists to detect the presence of aquatic species from the tiny bits of genetic material they leave behind. This “DNA soup” offers clues about biodiversity changes in sensitive areas, the presence of rare or endangered species, and the spread of invasive species—all critical to understanding, promoting, and preserving a healthy ocean. Researchers combined two novel autonomous platforms developed by MBARI for this study: the long-range autonomous underwater vehicle (LRAUV) and the Environmental Sample Processor (ESP). The LRAUV is a nimble underwater robot that can travel to remote areas of the ocean for extended periods of time. The ESP is a robotic “laboratory-in-a-can” that filters seawater and preserves eDNA for future study. By equipping an LRAUV with ESP technology, researchers can expand the scale of ocean monitoring over time and space. By comparison, traditional sampling of eDNA in the ocean requires weeks on an expensive research vessel limited to a localized area. Technology innovations like this are revolutionizing ocean conservation efforts. MBARI researchers launch a long-range autonomous underwater vehicle (LRAUV) from the R/V Paragon in Monterey Bay. These nimble robots can travel to remote areas of the ocean that are difficult for a crewed vessel to access. Credit: Kim Fulton-Bennett © 2014 MBARI “We know that eDNA is an incredibly powerful tool for studying ocean communities, but we’ve been limited by what we can accomplish using crewed research vessels. Now, autonomous technology is helping us make better use of our time and resources to study new parts of the ocean,” said Kobun Truelove, a biological oceanographer at MBARI and the lead author on the paper. Benefits of Autonomous eDNA Sampling for Ocean Conservation Marine biodiversity is a measure of the abundance of individuals and species in the ocean. This interconnected mosaic of organisms—from the smallest plankton to the largest whales—supports food webs, produces the air we breathe, and regulates our climate. Autonomous tools like the LRAUV and ESP enable MBARI researchers to maintain a persistent presence in the ocean and monitor changes in sensitive ecosystems in ways that were not possible previously. “Organisms move as conditions change in our oceans and Great Lakes, affecting the people and economies that rely on those species. We need cheaper and more nimble approaches to monitor biodiversity on a large scale. This study provides the synergistic development of eDNA and uncrewed technologies we need, in direct response to priorities laid out in the NOAA ‘Omics Strategic Plan,” said Kelly Goodwin, a co-author on the study and collaborator at the National Oceanic and Atmospheric Administration (NOAA). Background For this research, MBARI collaborated with researchers at the NOAA Atlantic Oceanographic and Meteorological Laboratory and the University of Washington to complete three expeditions in the Monterey Bay National Marine Sanctuary. The team coordinated sample collection between MBARI’s three research vessels, the NOAA Fisheries ship Reuben Lasker, and a fleet of MBARI’s LRAUVs. A ship-based team lowered bottles to a specific depth to collect and preserve water samples. Meanwhile, an LRAUV equipped with an ESP autonomously sampled and preserved eDNA at similar locations and depths. The eDNA samples were returned to the lab for in-depth sequencing. Metabarcoding: Translating eDNA into Biodiversity Insights Related organisms share common sections of DNA, known as gene markers. For this study, researchers analyzed eDNA samples with a technique known as metabarcoding. This method looks for short DNA excerpts and provides a breakdown of the groups present in the sample. This technique is especially helpful for translating eDNA data into a measure of biodiversity. The researchers analyzed four different types of gene markers, each representing a slightly different level of the food web. Together, the results yielded a more holistic picture of community composition. The samples collected from research ships and autonomous vehicles revealed similar patterns of biodiversity. Truelove noted that the findings from the study mark an exciting step forward for monitoring marine ecosystems. “This work is all about increasing the scale of eDNA research. Instead of looking at an individual species, we can start to more broadly characterize biological community structure in the ocean,” he said. “Good data are the bedrock of sustainable ocean management,” said Francisco Chavez, MBARI Senior Scientist and a co-author of the study. “Regular environmental DNA monitoring tells us who is there and what is changing over time. When it comes to understanding the impacts of climate change—one of the biggest threats to ocean health—this information is essential.” Future of Ocean Monitoring: LRAUVs and Autonomous Fleets LRAUVs are able to travel for weeks at a time and for hundreds of kilometers. They can enable more frequent sampling in areas of interest than traditional research vessels, which typically only visit remote sites infrequently. Autonomous robots will allow researchers to study previously unsurveyed regions of the ocean. Filling in these data gaps is critical to strengthening global ocean health. Ship-based research will continue to play an important role in oceanographic studies, but adding new autonomous technology to the toolkit will expand capacity for research, monitoring, and resource management. Ultimately, MBARI researchers envision deploying a fleet of LRAUVs equipped with ESP technology. Reference: “Expanding the temporal and spatial scales of environmental DNA research with autonomous sampling” by Nathan K. Truelove, Nastassia V. Patin, Markus Min, Kathleen J. Pitz, Chris M. Preston, Kevan M. Yamahara, Yanwu Zhang, Ben Y. Raanan, Brian Kieft, Brett Hobson, Luke R. Thompson, Kelly D. Goodwin and Francisco P. Chavez, 17 May 2022, Environmental DNA. DOI: 10.1002/edn3.299 Support for this research was provided by the David and Lucile Packard Foundation, NOAA/OAR/’Omics, NOAA/OAR/NOPP, and NASA Projects #80NSSC20M0001 and 80NSSX21M003. About MBARI MBARI (Monterey Bay Aquarium Research Institute) is a private non-profit oceanographic research center founded by David Packard in 1987. The mission of MBARI is to advance marine science and technology to understand a changing ocean. University of California, Irvine biologists have discovered that by eliminating the SAPS3 component of the AMPK protein complex, mice were able to maintain a normal energy balance even when consuming a high-fat diet. This finding, published in Nature Communications, reveals the potential for developing molecules that inhibit SAPS3 to help restore metabolic balance and combat metabolic disorders like obesity, diabetes, and fatty liver disease. As metabolic-related diseases continue to rise globally, this research could lead to a new approach in treating these conditions. Biologists discover removing a protein inhibitor restores metabolic balance. UC Irvine biologists found that removing the SAPS3 component in mice allowed them to maintain a normal energy balance despite consuming a high-fat diet. This discovery could lead to treatments for obesity, diabetes, and other metabolic disorders by targeting SAPS3 inhibition. Eating lots of fats increases the risk of metabolic disorders, but the mechanisms behind the problem have not been well understood. Now, University of California, Irvine (UCI) biologists have made a key finding about how to ward off harmful effects caused by a high-fat diet. Their study was published recently in the scientific journal Nature Communications. The UC Irvine research centered on a protein complex called AMPK, which senses the body’s nutrition and takes action to keep it balanced. For example, if AMPK detects that glucose is low, it can boost lipid breakdown to produce energy in its place. Scientists have known that consuming high amounts of fat blocks AMPK’s activity, leading the metabolism to go out of balance. However, until now, how cells block this mechanism has not been widely examined, especially in live models. Blocking SAPS3 to Boost AMPK Activity The UCI biologists decided to investigate, believing an AMPK component called SAPS3 serves a significant role. They eliminated SAPS3 from the genome of a group of mice and fed them meals with a 45 percent fat content. The results were startling even to the research team. Mei Kong is a professor of molecular biology & biochemistry and the study’s corresponding author. Credit: UCI School of Biological Sciences “Removing the SAPS3-inhibiting component freed the AMPK in these mice to activate, allowing them to maintain a normal energy balance despite eating a large amount of fat,” said Mei Kong, professor of molecular biology & biochemistry and the study’s corresponding author. “We were surprised by how well they maintained normal weight, avoiding obesity and development of diabetes.” Potential New Treatments for Metabolic Diseases The discovery could eventually lead to a new way to approach metabolism-related conditions. “If we block this inhibition activity, we could help people reactivate their AMPK,” said first author Ying Yang, a project scientist in the Kong lab. “It could help in overcoming disorders such as obesity, diabetes, fatty liver disease, and others. It’s important to recognize how important normal metabolic function is for every aspect of the body.” The researchers are working on developing molecules that could inhibit SAPS3 and restore the metabolism’s balance. They plan to next study SAPS3’s role in other conditions with disturbed metabolic systems, such as cancer and aging. The discovery comes as metabolic-related diseases such as obesity and diabetes continue to rise. More than half of the global population is expected to be overweight or obese by 2035, compared to 38 percent in 2020, according to the World Obesity Federation. The number of people worldwide with diabetes is expected to rise to 578 million by 2030, up 25 percent from 2019, reports the National Center for Biotechnology Information. Reference: “SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice” by Ying Yang, Michael A. Reid, Eric A. Hanse, Haiqing Li, Yuanding Li, Bryan I. Ruiz, Qi Fan and Mei Kong, 13 March 2023, Nature Communications. DOI: 10.1038/s41467-023-36809-1 Support for the project was provided by the National Institutes of Health and the American Cancer Society. RRG455KLJIEVEWWF |
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